Synthivan


QUICK OVERVIEW

Generic Name : Atazanavir And Ritonavir
Category : HIV Drugs
Company Name : Cipla Ltd
Dosage Form : 30 TABLETS
Strength : 300mg + 100mg

  

Availability: In Stock

Medicine Overview of Synthivan


Uses of Synthivan Tablet


Synthivan 300/100mg is a antiviral drug which is used  for the treatment of human immunodeficiency virus infection in adult and pediatric patients of age at least 3 months and weigh at least 22lb(10kg). Synthivan will reduce the amount of HIV in the blood.

 

Side effects of Synthivan Tablet


Synthivan is a protease inhibitor which cause common and severe side effects for the patients as follows:

Sign of allergic reaction: breathing difficulty, hives, swelling of your face, lips, tongue or throat.

New infection signs: night sweat, swollen glands, weight loss,

Cardiac symptoms: chest pain, rapid heart rate,

Ulcerative : cold sores, sores on your gential or anal area.

Reproductive symptoms : menstrual changes, impotence, loss of interest in sex

Respiratory symptoms: dry cough, wheezing, shortness of breath

If you have following side effects stop taking synthivan:

Headache with chest pain and severe dizziness, fast heartbeat.

Jaundice

Hypertension

Severe skin reaction

Common side effects: nausea , vomiting, headache, muscle pain, numbness of burning pain in your hands or feet

How to use Synthivan Tablet

In adult dose:

Synthivan oral dosage is based on the treatment history of patients, use of other combination drugs. Synthivan co administration with proton pump inhibitors then dose separation may be required.

Synthivan capsule are recommended for experienced treatment in adult and pediatric patients with before the virologic failure.

 Recommended dosage of Synthivan capsule in treatment for new adult patients prescribed as

atazanavir (synthivan)  300mg and Ritonavir 100mg once daily

unable to tolerate Ritonavir then atazanavir (synthivan) 400mg once daily

When both drugs in combination with Efavirenz then atazanavir (synthivan)  400mg and Ritonavir 100mg once daily

In treatment for experienced adult patients:

Recommended dose is atazanavir (synthivan)  300mg and Ritonavir 100mg once daily

Drugs combination with both H2RA and Tenofovir synthivan and Ritonavir 100mg once daily.

 In pediatric patients dose:

Dosage prescribed for patients 6 years to < 18yrs according to the body weight.

In naïve and experienced treatment

< 15 kg – capsules not recommended

15kg to < 20kg – Atazanavir (synthivan) 150mg and Ritonavir 100mg

20kg to < 40 kg – Atazanavir (synthivan)  200mg and Ritonavir 100mg

At least 40 kg – Atazanavir (synthivan) 300mg and Ritonavir 100mg

In new treatment at least 13 years old and cannot tolerate Ritonavir

Atleast 40kg – Atazanavir (synthivan)  400mg without Ritonavir

Atazanavir (synthivan)  should be administrated with food in adult and pediatric.

Overdose : Synthivan has no Specific antitoxin are available  and immediately seek emergency department or poison contol helplline

How to Synthivan Tablet works:


Atazanavir (synthivan) is an antiretroviral drug. Atazanavir and ritonavir  is performed as azapeptide HIV-1 protease inhibitor (PI).

The drug specifically prevents the virus-unique processing of viral Gag and Gag-Pol polyproteins in HIV-1 infected cells of human

Hence interfere with the formation of mature group of virus.

Absorption: rapidly absorbed, peak plasma concentration is 2.5 hours for atazanavir and Ritonavir is 2-4 hours. Synthivan enhances the bioavilability with food . bioavilabilty is 60-68%

Distribution: human serum proteins bound is 86% of Atazanvir and for Ritonavir 98%

Metabolism : Both the drug  metabolized  primarily in liver, In vitro synthivan metabolized by CYP3A.

Elimination : Single dose of synthivan 400mg eliminated the total radioactivity was recovered in feces 79% and urine 13%.and unchanged  administrated dose in feces is 20% and urine 7%. While in Ritonavir eliminated via faeces approx 86% and 3.5% as unchanged drug via urine approx 11%.

Terminal end half life is approx 7 hours and Ritonavir has 3-5 hour


In Depth Information on Synthivan Tablet:


Expert Advice for Synthivan Tablets


  • Avoid using of  proton-pump inhibitors in experienced treatment patients
  • if serious rash occur discontinue the drug;, erythema ,toxic skin eruptions reported
  • Body fat Aggregation, such as  obesity in central body, buffalo hump, wasting in facial , peripheral and  breast enlargement have been seen  in patients taking antiretroviral drug.
  • Spontaneous bleeding may occur, stop the drug and consult with doctor
  • ECG monitoring must be done in patients when administered with other drugs that may prolong the PR interval
  • Chronic kidney disease in HIV-infected patients treated with synthivan has been reported during postmarketing surveillance. Do the renal laboratory testing in all patients before to and during therapy; some doctors advised for patients who have noticed renal laboratory abnormalities while on treatmen, consider stoppage of treatment.
  • Stone formation in kidney and gallbladder is reported; consider temporary Stoppage or discontinuation.
  • Before virologic failure with experienced treatment patients: without ritonavir not recommended
  • Treatment with Synthivan, the patients may cause Worsening of diabetes mellitus and increase in glucose level, immune reconstitution syndrome,
  • Hepatitis B or C infection in patients are at risk of increased transaminases shoud be  check hepatic laboratory tests before to  the treatment and during treatment.

Special Warnings of Synthivan Tablets


Alcohol

Alcohol interaction with Synthivan tablet is unknown. Please consult with the doctor.

Pregnancy

Category B :Studies on animal and human described that Synthivan will not increase the risk of major birth defects. Synthivan has been estimated in limited of women during pregnancy and postpartum, hence drug is probably safe to use during pregnancy only If clearly needed.

Lactation

 While on treatment with Synthivan breast feeding is not recommended. Its necessary mother breast feeding their infants to avoid risk of transmission

Driving

Avoid driving while on treatment with Synthivan because it will make you feel sleepy, tried or reduce alertness


Kidney

Patients with mild to moderate renal problem are preferably safe to use Synthivan tablet. Limited data available suggests that dose adjustment of Synthivan Tablet may not be required in these patients. Please consult with your doctor.

Liver

Synthivan tablet must be used with caution while on treatment for liver disease. Dose  adjustment is necessary. In moderate and severe liver disease, the Synthivan is not recommended to use. Please consult with the doctor for further details.



Missed Dosage

As soon as you remember take the missed dose. If time for next dose then skips the missed dose and follow the routine scheduled. Do not take more than one tablet per day. Please consult your doctor for changes in dose or new schedule for replace of missed dose.


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Synthivan

 
Brand Name : <--------------------> Synthivan
Category : <--------------------> HIV Drugs
Sub Category :<--------------------> Atazanavir And Ritonavir
Company Name :<--------------------> Cipla Ltd
Ingeridents(Generic Name) :<--------------------> Atazanavir And Ritonavir
Tablets :<--------------------> 30 TABLETS
Package :<--------------------> 1X30
Strength :<--------------------> 300mg + 100mg

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