Efavir


QUICK OVERVIEW

Generic Name : Efavirenz
Category : HIV Drugs
Company Name : Cipla Ltd
Dosage Form : 30 TABLETS
Strength : 600mg

  

Availability: In Stock

Medicine Overview of Efavir


Uses of Efavir Tablet


In adult and childerns 3 months old / weight of 3.5kg, Efavir is used by combination with other antiretroviral regimens for the treatment of HIV-1 type(human immunodeficiency virus).

Efavir 600mg indication depends on two clinical trials which demonstrated prolonged elimination of HIV RNA for 1 year duration.

Side effects of Efavir Tablet


Rash and erythema multiforme

CNS effects like dizziness, headache, insomnia, somnolence, abnormal dreams, fatigue, impaired concentration.

Serious side effects

  • Nausea and vomiting,
  • loose stools,
  • hepatitis, depression, anxiety, psychosis, amnesia and ataxia, stupor,
  • abdominal pain, , pancreatitis
  • liver failure, ,
  • convulsions,
  • gynaecomastia,
  • pruritus,
  • blurred vision.

How to use Efavir Tablet

 In adult recommended for the treatment of the HIV-1infection and used with combination of other antiretrovirals dosage of 600mg once daily (capsule/tablet) and solution of 720mg once daily.

Efavir should administrated with empty stomach, preferably bedtime.

 In pediatric dose for 3 years of age or older or weighing between 10 and 40kg is 600mg once daily administrated orally in empty stomach, preferably bed time.

OVERDOSE : If accidentally if patients taking 600mg of efavir  two times a day have reported nervous symptoms has increased. Some patients will have muscle contractions. Using of activated charcoal to aid removal of unabsorbed drug.

How to Efavir Tablet works:


Efavir is an non nucleoside reverse transcriptase inhibitor that fight against HIV-1 and stops HIV-1 replication and RNA & DNA dependent polymerase activities.

ABSORPTION: Efavirenz (Efavir) ,bioavailabilty is 42% and Peak plasma concentration is 3-5hr.

DISTRIBUTION:. Efavirenz (Efavir)  is distributed in CSF, enter into breast milk and protein bound is 99%

METABOLISM:  Efavir metabolized mainly in CYP3A4 and CYP2B ELIMINATION: In Efavir eliminated through urine(14-34%) and faeces is 16-61%

 Terminal half life is 52-76hr(single dose) and 40-55hr (multiple dose).


In Depth Information on Efavir Tablet:


Expert Advice for Efavir Tablets


Monitor the patients with these problems and inform the healthcare providers:

  • cholesterol and triglycerides.
  • LFTs in patients with history of hepatitis B and/or C.Hepatic Function Use. 
  • CNS symptoms 
  • Accumulation of  fat in the body, involves central obesity, dorsocervical fat enlargement, peripheral wasting, facial wasting, breast enlargement.. 
  • liver enzymes in patients with suspected past of hepatitis B or C infection and liver toxicity. 
  • Immune reconstitution syndrome . Lipids rises in total cholesterol and triglycerides have been checked,. 
  • Psychiatric symptoms  psychiatric disorders may be at greater risk. There have been occasional reports of death by suicide, delusions, and psychosis-like behavior. 

 


Special Warnings of Efavir Tablets


Alcohol

Efavir 600mg  interaction with alcohol will cause liver problem. Please consult the doctor.

Pregnancy

Based on adverse effects by investigation and experience studies in humans a positive identification of human fetal risk is reported. Hence Efavir 600mg is unsafe  during pregnancy but the essential from use in pregnant women may be acceptable against risk like life threatening. Please  consult with doctor.

Lactation

While on treatment with Efavir 600mg breast feeding is not recommended. Its necessary mother breast feeding their infants to avoid risk of transmission.

Driving

Avoid driving while on treatment with Efavir 600mg because it will make you feel sleepy, tried or reduce alertness.


Kidney

Patients with mild to moderate renal problem are preferably safe to use Efavir 600mg tablet. Limited data available suggests that dose adjustment of Efavir Tablet may not be required in these patients. Please consult with your doctor.

Liver

Efavir 600mg tablet must be used with caution while on treatment for liver disease. Dose  adjustment is necessary. In moderate and severe liver disease, the abalam is not recommended to use. Please consult with the doctor for further details



Missed Dosage

As soon as you remember take the missed dose. If time for next dose then skips the missed dose and follow the routine scheduled. Do not take more than one tablet per day. Please consult your doctor for changes in dose or new schedule for replace of missed dose.


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Efavir

 
Brand Name : <--------------------> Efavir
Category : <--------------------> HIV Drugs
Sub Category :<--------------------> Efavirenz
Company Name :<--------------------> Cipla Ltd
Ingeridents(Generic Name) :<--------------------> Efavirenz
Tablets :<--------------------> 30 TABLETS
Package :<--------------------> 1X30
Strength :<--------------------> 600mg

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