Viraday


QUICK OVERVIEW

Generic Name : Tenofovir Disoproxil Fumarate / Efavirenz/Emtricitabine
Category : HIV Drugs
Company Name : Cipla Ltd
Dosage Form : 30 TABLETS
Strength : 300mg+200mg+600mg

  

Availability: In Stock

Medicine Overview of Viraday


Uses of Viraday Tablet


Viraday is used with combination of antiretroviral drug or alone medicine in adult and children 12yrs / >12yrs for the treatment of HIV-1 infection.

Side effects of Viraday Tablet


Major effects: Lactic acidosis, severe hepatomegaly with steatosis

Renal effects: Nephritis, Nephrogenic, diabetes insipidus, renal failure

Gastro intestinal : less oxygen level, abdominal distention, diarrhea, dyspepsia, flatulence

Common effects: vertigo, fatigue, raised liver enzyme, athralgia,rhabdomyolysis, osteomalacia.

How to use Viraday Tablet

 In adult

Viraday tablet  administrated  only at bedtime, one tablet orally in an empty stomach.

In children,

Safety and efficacy of drug is not recommended at age <18yrs. Since it is fixed dose combination

How to Viraday Tablet works:


An acyclic nucleoside phosphonate di ester associate  of adenosine monophosphate is Tenofovir Disoproxil Fumarate (Viraday), that  hydrolysed to Tenofovir, finally  cellular enzymes phosphorylated  to form Tenofovir diphosphate, an restrict  chain terminator. Tenofovir  involves  with  DNA synthesis of HIV through aggressive inhibition of reverse transcriptase and fusion into viral DNA. Tenofovir  also prevents  hepatitis B virus polymerase, resulting in blockage  of viral replication.

 A synthetic nucleoside coordinate of cytidine is called emtricitabine, that  go via  phosphorylation occurring in- vitro cell to emtricitabine 5'-triphosphate, then take part  with deoxycytidine 5'-triphosphate and is incorporated into viral DNA which leads to  chain termination. Emtricitabine activity against HIV-1, HIV-2 viruses  and hepatitis B virus (HBV) while Efavirenz is an non nucleoside reverse transcriptase inhibitor that fight against HIV-1 and stops HIV-1 replication and RNA & DNA dependent polymerase activities.

ABSORPTION:

  • Viraday (Efavirenz)   , bioavailabilty is 42% and PPC is 3-5hr.
  • while  In Viraday (emtricitabine) , bioavailability is 93%(capsulel) and solution 75%, PPC is 1-2 hrs .
  • Viraday (Tenofovir) immediately absorbs from the GI tract, bioavailability is 25% approximately  and time to peak plasma concentration (PPC) is 1-2hr..

DISTRIBUTION:

  • Viraday (Efavirenz)  is distributed in CSF, enter into breast milk and protein bound is 99%
  • Viraday (Tenofovir)  volume of distribution is 1.2-1.3 L/kg and plasma protein binding is <1%,
  • In Viraday (Emtricitabine)  independent of concentration and protein binding is <4%.

METABOLISM:

  • Viraday (Tenofovir Disoproxil Fumarate) ,that  hydrolysed to Tenofovir, finally  cellular enzymes phosphorylated  to form Tenofovir diphosphate, an restrict  chain terminator. In
  • Viraday(Emtricitabine)  is limited metabolism.
  • while in Viraday( Efavirenz )mainly metabolized inCYP3A4 and CYP2B and isoenzyme to inactive hydroxyl metabolite.

ELIMINATION:

  • Viraday ( Tenofovir) excreted through urine by active glomerular filtration and tubular secretion and half life is 18hr.
  • Viraday (Emtricitabine)  eliminated highly unchanged in urine and low limit in faeces, half life is 10hr.
  • In Viraday ( Efavirenz) eliminated through urine(14-34%) and faeces is 16-61%
  • terminal half life is 52-76hr(single dose) and 40-55hr (multiple dose).

In Depth Information on Viraday Tablet:


Expert Advice for Viraday Tablets


  • Patient with hepatomegaly or other serious factors for liver disease, Renal impairment, Pregnancy. 
  • Patient Counseling: This drug may cause dizziness, if affected, do not drive or operate machinery. 
  • Monitoring  Parameters:  Check the renal function and serum phosphate concentrations before start of the treatment, 4 weekly during the 1st week, and then 3 monthly.
  • Hepatic function for several months following  discontinuation. Determine HIV status in all hepatitis B virus (HBV) infected patients before the treatment.

Special Warnings of Viraday Tablets


Alcohol

Taking efavirenz with alcohol interaction may cause liver problem.While taking viraday take precaution.

Pregnancy

Efavirenz (Viraday) has category D:Based on adverse effects by investigation and experience studies in humans a positive identification of human fetal risk is reported Tenofovir and Emtricitabine (Viraday)  has category B: Animal studies have been developed adverse effect, but sufficient and well-tolerated studies in pregnant women which have failed to develop arisk to the fetus in all trimester in pregnancy.

Lactation

Viraday preferably safe to use during breast feeding. Limited information available for represent specific risk to the baby.

Driving

Avoid driving while on treatment with Viraday because it will make you feel sleepy, tried or reduce alertness.


Kidney

Patients with mild to moderate renal problem are preferably safe to use Viraday tablet. Limited data available suggests that dose adjustment of ViradayTablet may not be required in these patients. Please consult with your doctor.

Liver

Patients with mild to moderate hepatic problem are preferably safe to use Viraday tablet. Limited data available suggests that dose adjustment of  Viraday Tablet may not be required in these patients. Please consult with your doctor.



Missed Dosage

As soon as you remember take the missed dose. If time for next dose then skips the missed dose and follow the routine scheduled. Do not take more than one tablet per day. Please consult your doctor for changes in dose or new schedule for replace of missed dose.

 


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Viraday

 
Brand Name : <--------------------> Viraday
Category : <--------------------> HIV Drugs
Sub Category :<--------------------> Tenofovir Disoproxil Fumarate / Efavirenz/Emtricitabine
Company Name :<--------------------> Cipla Ltd
Ingeridents(Generic Name) :<--------------------> Tenofovir Alafenamide/ Emtricitabine /Efavirenz
Tablets :<--------------------> 30 TABLETS
Package :<--------------------> 1X30
Strength :<--------------------> 300mg+200mg+600mg

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