Intacept 50mg


QUICK OVERVIEW

Generic Name : Etanercept
Category : Orthopedic Drugs
Company Name : Intas Pharmaceuticals Ltd
Dosage Form : 1 vial
Strength : 50mg/1ml

  

Availability: In Stock

Medicine Overview of Intacept 50mg


Uses of Intacept 50mg Tablet


Intacept 50mg/1ml is a type of classification known as tumor necrosis factor (TNF) inhibitor. Intacept used alone or with another medication for recovering from the symptoms of certain autoimmune disorders, condition that immune system affects the normal parts of the body and leads to pain, swelling and damage and Intacept indicated for the treatment of

  • rheumatoid arthritis,
  • psoriatic arthritis,
  • juvenile idiopathic arthritis,
  • ankylosing spondylitis,
  • chronic plaque psoriasis

 

Side effects of Intacept 50mg Tablet


Some Side effects occurs by intacept. Consult your doctor if it gets serious or not curing.

  • Site of injection: redness, itching, pain or swelling
  • Head pain
  • Vomiting
  • Heartburn
  • Stomach ache
  • Weakness
  • Cough

Some major effects may be serious. If it occurs call your doctor immediately.

  • seizures
  • bruising
  • bleeding
  • pale skin
  • rash, hives, itching
  • red, scaly patches or pus filled bumps on the skin
  • breathing difficulty

How to use Intacept 50mg Tablet

 ADULT DOSE:

  • For Ankylosing spondylitis: 50mg SC (subcutenously ) once a week.

  • For Rheumatoid arthritis: 50mg SC once a week

  • For Psoriatic arthritis: 50mg SC Once a week

  • For Plaque Psoriasis: intial dose of 50mg Subcutaneously 2 times week for 3 months alternatively, starting dose 25 – 50mg once a week is effective.

PEDIATRIC DOSE:

For juvenile idiopathic arthritis is used for 2yrs and older

  • < 63KG: 0.8mg/kg SC once a week.

  • ≥ 63kg : 50mg subcutaneously once a week

  • Max dose: 50mg subcutaneously once a week

For Plaque Psoriasis is used for 4years and older

  • < 63kg: 0.8mg/kg SC once a week

  • ≥ 63kg : 50mg subcutaneously once a week

  • Max dose: 50mg subcutaneously once a week

 Administration of intacept tablet

Intacept injection is an  prefilled syringe  with automatic injection device contains solution form or liquid. In it contain a powder to be mixed with a provided liquid.

Intacept injected in under the skin ( subcutaneously) for once a week.

In case of chronic psoriasis, It may be injected twice a week for first 3 months of treatment and then once a week after the first 3 months.

First given by doctors office then next dose you can administer at home or by a friend.

Intacept left out medicine after giving one dose store it for 14 days  in a refrigerator as soon as possible don’t delay than 4 hours after mix it.

Do not shake the syringe, injection device or a vial. Carefully handle the injection.

OVERDOSAGE: No dose – limiting toxicities were observed on studies of clinical trials and maximum tolerated dose of intacept has not been established in humans. The highest dose level calculated in rheumatoid arthritis patients has been an IV  loading dose of 32 mg/m2 followed by subcutaneous doses of 16 mg/m2 (~25 mg) administered two times in weekly. No known antidote

How to Intacept 50mg Tablet works:


It decreases the effect of naturally present Tumor necrosis factor and hence It works by TNF inhibitor, functioning as a decoy receptor that bounds to TNF.[17]

Tumor necrosis factor-alpha is a Cytokine produced by two types of WBC ( Lymphocytes and Macrophages),. It interfere the immune response by appeal to additional white blood cells to sites of inflammation, and via additional molecular mechanisms which start and develop to inflammation. Prevention of its action by intacept reduces the inflammatory response which is especially useful for treating autoimmune disease

  • Absorption: slowly after sub Q injection
  • Excretion : age of 4 to 17 years – 46ml/hour/m2 of clearance Adults – 160 ± 80 ml/hour
  • Onset of action:  2 to 3 weeks ; for RA 1 to 2 weeks ; max effects is seen within 3 months.
  • Time to peak : RA: Sob Q 69 ± 34 hours.
  • Half life elimination : children and adolescents is 70 to 94.8 hours, for adults (RA) is 102± 30 hours.

In Depth Information on Intacept 50mg Tablet:


Expert Advice for Intacept 50mg Tablets


Inform your doctor If suffers from any conditions and consult before using of intacept

  • Allergic to intacept or any other drugs or prefilled syringe rubber or latex
  • If you had seizures, multiple sclerosis, optic neuritis, bleeding problem, liver disease, heart problem.
  • Any of the surgery, including dental
  • Other medications which involves in prescription, over-the-counter, vitamins, herbal remedies, etc.and avoid Aspirin, or products related to aspirin your consultants  permits this specifically.
  • Some type of  immunization or vaccination should avoided unless your doctor's approval.
  • Inform your Consultant if you are pregnant or planning to  pregnant before  starting the treatment
  • In women and partner men: avoid conceive a child (get pregnant) . Barrier methods of contraception, such as condoms, are recommended. Consult the doctor for that you may safely become pregnant or conceive a child after therapy.
  • Due to severe adverse reactions in the new born baby, breast-feeding is not recommended.
  • If any exposed to chickenpox.

Special Warnings of Intacept 50mg Tablets


Alcohol

 Interaction of alcohol with intacept 50mg/1ml injection is unknown. Please consult with the doctor

Pregnancy

Category B : There are no sufficient and well-tolerated studies in pregnant women and shown risk to the fetus in ant trimester. The drug is probably safe during pregnancy and In animal reproduction studies have failed to reveal about a risk to the fetus.

Lactation

Intacept 50mg/1ml injection has less excretion into breast milk and infants absorbed poorly.the expert feels that low risk occurs the nursing infants and can be administer during breastfeeding.

Driving

The intacept 50mg/1ml injection usage will affect the ability of driving is not known but if you experience any symptoms then avoid the driving until you feeling well.


Kidney

Intacept 50mg/1ml injection is probably safe to use in patient having kidney problem. Limited data are only available. Dose adjustment may not be needed. Please consult with the doctor

Liver

Intacept 50mg/1ml injection is probably safe to use in patient having hepatic problem. Limited data are only available. Dose adjustment may not be needed in these patients. Please consult with the doctor



Missed Dosage

The drug dose is missed, then take the drug dose as soon as possible. If next dose time arrived then skip the missed dose and continue the routine schedule. Avoid taking extra dose or 2 dose at one time. Please consult your doctor for further clarification.


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Intacept 50mg

 
Brand Name : <--------------------> Intacept 50mg
Category : <--------------------> Orthopedic Drugs
Sub Category :<--------------------> Etanercept
Company Name :<--------------------> Intas Pharmaceuticals Ltd
Ingeridents(Generic Name) :<--------------------> Etanercept
Tablets :<--------------------> 1 vial
Package :<--------------------> 1x1
Strength :<--------------------> 50mg/1ml

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