Mydekla


QUICK OVERVIEW

Generic Name : Daclatasvir
Category : Hepatitis Drugs
Company Name : Mylan
Dosage Form : 28 Tablets
Strength : 60 mg

  

Availability: In Stock

Medicine Overview of Mydekla


Uses of Mydekla Tablet


Mydekla 60mg  is an anti-viral drug which is  useful for the treatment of chronic hepatitis C viral infection by preventing the multiplication of hepatitis C virus. Mydekla is included  to treatment of genotype III advanced hepatitis C virus in adults without cirrhosis

Generally Mydekla  60mg  tablets are not administrated alone, it may combined with other anti-viral medicines like Sofosbuvir, interferon and ribavirin

Side effects of Mydekla Tablet


Serious side effects of mydekla 60mg

Digestive problem: decreased appetitie

Cardiovascular: symptomatic bradycardia, heart block, cardiac aeehythnias

Liver problems: increased ALT and AST, rise in total bilirubin

Musculoskeletal: myalagia, athralgia, back pain

Genitourinary : UTI

Central nervous system: headache, dizziness,migraine

Mental disorder: insomnia, irritability, anxiety

Ocular: dry eye

Common side effects of Mydekla 60mg

Allergic reaction, breathing difficulty, swelling of peripheral organs

Combination Mydekla 60mg with amiodarone causes very slow heartbeat, chest pain, dyspnae.

How to use Mydekla Tablet

The doctor prescribe Mydekla 60mg based on age, past medical history and current status of diagnosis.

             When Mydekla 60mg combined with Sofosbuvir the dose recommended is one tablet of 60mg taken once in a day by oral route with or without food. Duration of treatment – 12weeks

Modification of dose :  Reduce 30mg OD for strong CYP3A leads no  Dose reduction. Increase dose to 90mg OD with moderate  CYP3A leads to contraindicated.

For genotype 1 or 4 : treatment with daclatasvir +ribavirin+ peg IFN for 12 weeks

For genotype 2 : treatment with daclatasvir + ribavirin for 12 weeks

For genotype 3: treatment with daclatasvir + ribavirin (without interferon) for 24 weeks.

OVERDOSAGE: Mydekla overdose has no particular antidote. Treatment will consist of supportive measures, involving monitoring of vitals and patient clinical status observation.

How to Mydekla Tablet works:


Mydekla 60mg is a direct acting antiviral drug which is used for the patient affected by hepatitis c virus infection. It will targets the Hepatitis C virus and blocks the numerous steps in reproduction process of HCV by the way it interfere with the virus particles from making copies themselves, and  helps the body to remove virus  from the blood.

  • Absorption: Poor absorption, peak plasma concentration is 2 hours post dose and bioavailability is 67%

  • Distribution: while multiple dosing, plasma protein binding is 99%, on dialysis it significantly decrease the plasma binding and vol of distribution is 47L
  • Metabolism: Daclatasvir is primarily metabolized through CYP3A4
  • Elimination: Daclatasvir excreted through feces of  (88%,53% unchanged) ; urine (6.6% primarily unchanged).
  • Terminal half life elimination is 12 – 15 hours

In Depth Information on Mydekla Tablet:


Expert Advice for Mydekla Tablets


  • Combination of  Mydekla 60mg and amiodarone may cause bradycardia
  • Drugs should given with prescription only, without prescription drugs should not be issued.
  • Inform your healthcare providers that you are allergic to daclatasvir ,Sofosbuvir or  have any other allergies before using the medicine. It may composed of inactive ingredients, that can  be cause allergic problems or other reaction. Talk to your pharmacist for more details.

  • If you had any  kidney disease, liver disease other than hepatitis C, inform your consultant about past medical history before having daclatasvir / Sofosbuvir.


Special Warnings of Mydekla Tablets


Alcohol

There is no data available for Mydekla 60mg. Please consult your doctor

Pregnancy

Pregnancy category for Mydekla 60mg is not Predicted, when oral dose the animal studies have failed to explain the signs of fetal harm. There are no controlled data in human pregnancy. This drug should use with combination of other antiviral drug. Use of ribavirin containing regimen is contraindicated in pregnant women and the male partner. For some authorities, this drug should avoid during pregnancy.

Lactation

Low amount of this drug  in breast milk as Mydekla 60mg is highly bound to maternal plasma protein, If the drug require for the feeding mother and it is not a reason for discontinue breastfeeding, If the drug using with ribavirin avoid breast feeding

Driving

While taking  Mydekla 60mg you will feel dizziness, difficulty in concentrating and vision problem this may affect your driving. So avoid driving till you feeling well.


Kidney

Mydekla 60mg has  no dosage adjustment recommended with renal dysfunction. Please consult with your doctor

Liver

Mild, moderate or severe liver dysfunction has no dose adjustment recommended in Mydekla 60mg. Please consult with your doctor



Missed Dosage

As soon as you remember take the missed dose. If time for next dose then skips the missed dose and follow the routine scheduled. Do not take more than one tablet per day. Please consult your doctor for further details.


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Mydekla

 
Brand Name : <--------------------> Mydekla
Category : <--------------------> Hepatitis Drugs
Sub Category :<--------------------> Daclatasvir
Company Name :<--------------------> Mylan
Ingeridents(Generic Name) :<--------------------> Daclatasvir
Tablets :<--------------------> 28 Tablets
Package :<--------------------> 3x28
Strength :<--------------------> 60 mg

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