Hepbest


QUICK OVERVIEW

Generic Name : Tenofovir Alafenamide
Category : Hepatitis Drugs
Company Name : Mylan
Dosage Form : 30 TABLETS
Strength : 25MG

  

Availability: In Stock

Medicine Overview of Hepbest


Uses of Hepbest Tablet


Hepbest is a brand name of Tenofovir alafenamide. It is an antiretroviral drugs and involves in nucleotide reverse transcriptase inhibitor(NRTI). In adult is used  for the treatment of Chronic HBV infection with compensated liver disease and HIV infection.

Side effects of Hepbest Tablet


 Common effects: head pain ,cough and back pain

Incident not known:

  • Loss of appetite
  • Urine frequency is less
  • Rapid breathing

  • general feeling of discomfort
  • hypertension
  • more thirst
  • light-colored stools
  • lumbar pain
  • myalagia
  • right upper abdominal or stomach pain and fullness
  • sleepiness
  • swelling of the face, fingers, or lower legs
  • troubled breathing
  • unusual tiredness or weakness
  • jaundice

How to use Hepbest Tablet

In adult, Hepbest is used for the treatment of chronic HBV infection

25mg administer orally once in a day with food.

In pediatric, safety and efficacy not established <18years of age

IF OVERDOSE OCCURS: Seek to emergency medical care or call poison control centre immediately. Give all correct information.

How to Hepbest Tablet works:


Tenofovir alafenamide is belongs to class of antiviral drug against the hepatitis B virus.

Tenofovir alafenamide is a prodrug of tenofovir.

Tenofovir alafenamide is then converted to tenofovir disproxil Fumarate via loss of water primarily by carboxylesterase 1 (CES1) in primary hepatocytes. Tenofovir Intracellularily , finally phosphorylated by cellular kinases for the formation the pharmacologically active metabolite tenofovir diphosphate.It interfere with the Hepatitis B virus  proliferation via fusing into viral DNA by the HBV reverse transcriptase, which causes in DNA chain-termination.

Tenofovir diphosphate is a mammalian DNA polymerases which is an weak inhibitors and involves in mitochondrial DNA polymerase γ and there is no possibilities of toxicity to mitochondria in cell culture.

Absorption: Hepbest is a phosphonamide prodrug of Tenofovir, peak plasma concentration is approx 0.5hrs after the dose.

Food effect: Hepbest  with a high fat meal increase AUC compared with administration in fasted state.

Distribution: Plasma protein binding is 80%

Metabolism: Only minimal metabolized by CYP3A

Elimination: Excreted by kidneys , 32% of dose in feces and<1% excreted in  urine. Half life is 0.5hrs

 


In Depth Information on Hepbest Tablet:


Expert Advice for Hepbest Tablets


      Risk of development of HIV-1 resistance patients connect with HBV and HIV disease: Individual treatment of  Hepbest  should not be used for treatment of HIV infection causes risk of producing of HIV-1 resistance.

Discontinuation of hepatitis B treatment: If patient discontinued of Hepbest drug it will lead to severe acute exacerbation of HBV infection.hence liver function should monitor after several month discontinue of drug.

Lactic acidosis with steatosis: Hepbest 25 mg co administration of antiretroviral agaents or alone use will cause severe hepatomegaly including fatalities and lactic acidosis.

Risk of renal impairment: while taking Hepbest along with renal impaired function or nephrotoxic agents will increase risk of developing renal related side effects.


Special Warnings of Hepbest Tablets


Alcohol

On treatment with Hepbest 25mg drinking alcoholic beverages is safe or not depends upon number of factors involves the patient receiving drugs. Alcohol may inhibits some action of hepatitis drugs work. So patient should discuss with doctor about any adverse reaction of drinking during treatment.

Pregnancy

Category B : While Hepbest 25 mg during pregnancy ,no malformation, fetotoxicity or neonatal toxicity, Hepbest referred  for only limited number of pregnant women. In  animal reproduction studies have shown negative risk to the fetus and there no sufficient and well – tolerated studies in pregnant women. This drug harms the unborn baby.

Lactation

During hepbest 25mg treatment, breast feeding is avoided for the safety of the newborn baby. This drugs may included in breast milk in high levels and probably harm the baby. Check with the doctor whether breast feeding should stop temporarily or permanently while treatment

Driving

If dizziness, sleepy, tried or low alertness on drive happens then do not drive until you feeling well.


Kidney

Hepbest 25mg treatment of patients with mild moderate, severe renal impairment has no dose adjustment and the drug is not recommended in patients with end stage renal disease. Consult with your doctor for further details

Liver

Patient with decompensated hepatic impairment is not recommended with Hepbest treatment, because safety and efficacy is not been established. No adjustment is required. Consult with your doctor.



Missed Dosage

As soon as you remember take the missed dose. If time for next dose then skips the missed dose and follow the routine scheduled. Do not take more than one tablet per day. Please consult your doctor for changes in dose or new schedule for replace of missed dose.


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Hepbest

 
Brand Name : <--------------------> Hepbest
Category : <--------------------> Hepatitis Drugs
Sub Category :<--------------------> Tenofovir Alafenamide
Company Name :<--------------------> Mylan
Ingeridents(Generic Name) :<--------------------> tenofovir alafenamide
Tablets :<--------------------> 30 TABLETS
Package :<--------------------> 1X30
Strength :<--------------------> 25MG

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