Medicine Overview of X-vir
Uses of X-vir Tablet
X-vir 1mg Is indicated for the treatment of chronic hepatitis B virus infection in adult and childerns of >2yrs with report of active viral multiplication and either report of persistent increase in serum aminotransferase(ALT or AST) or histologically active disease.
X-vir 1mg is also indicated for the treatment of clinical trial data in nucleoside – inhibitor treatment new and lamivudine resistance subjects with HBeAg +ve and HBeAg –ve HBV infection.
Side effects of X-vir Tablet
Majority of the patients using X-vir 1mg have low to no side effects
Common side effects:
Gastriointestinal: diarrhea; dyspepsia; nausea; vomiting
Nervous system: headache; dizziness; somnolence
Urinary system: Glysouria; hematuria
Serious side effects: lactic acidosis; liver problem; liver enlargement; fat in the liver.
How to use X-vir Tablet
X-vir tablets with lamivudine or known lamivudine or telbivudine resistance substitions rtM204I/V with or without rtL180M, rtL80I/V, or rtV173L with past history of hepatitis B viremia in adult and adolescents (at least 16 years of age) the prescribed dose is 1 mg
X-vir given one tablet of 1mg once daily.
X-vir 1mg administrated on an empty stomach for atleast 2hrs after a meal or before the next meal.
Pediatric dose :
2 to 15 years for therapy new patients.
10 to 11 kg: 0.15 mg orally once a day
>11 to 14 kg: 0.2 mg orally once a day
>14 to 17 kg: 0.25 mg orally once a day
>17 to 20 kg: 0.3 mg orally once a day
>20 to 23 kg: 0.35 mg orally once a day
> 23 to 26 kg: 0.4 mg orally once a day
> 26 to 30 kg: 0.45 mg orally once a day
> 30 kg: 0.5 mg orally once a day.
Lamivudine experienced patient:
10 to 11 kg: 0.3 mg orally once a day
>11 to 14 kg: 0.4 mg orally once a day
>14 to 17 kg: 0.5 mg orally once a day
>17 to 20 kg: 0.6 mg orally once a day
>20 to 23 kg: 0.7 mg orally once a day
>23 to 26 kg: 0.8 mg orally once a day
>26 to 30 kg: 0.9 mg orally once a day
>30 kg: 1 mg orally once a day
OVERDOSAGE: If patients had single entecavir doses of 40mg or double dose of 20mg/day till 14days has no evidence of increase or any adverse effect. If overdose occurs then provide immediately supportive and symptomatic measurements such as vitals signs of toxicity of medicine.
How to X-vir Tablet works:
X-vir is belongs to the classification of antiviral drug and an nucleoside analogue show action against hepatitis B virus polymerase is effectively phosphorylated to the active triphosphate form, which require an intracellular half life of 15 hours. X-vir tablet combination with natural substances such as deoxyguanosine triphosphate functionally prevents all three activities of HBV reverse transcriptase:
- Base priming
- Ergonomic messenger RNA produce negative strand of reverse transcription
- Synthesis of positive strand of HBV DNA.
X-vir 1mg reduces the quantity of hepatitis virus in the blood and decrease the multiply and infect new cells by these three activities.
Absorption: X-vir has peak plasma concentration between 0.5 and 1.5 hours and bioavailability is 100% relative to the oral solution.
Effect of food: while on empty stomach is more effective for tablet absorption compared to with food.
Distribution: binding to human plasma protein of X-vir is 13 %
Metabolism: small amount of phase II metabolites (glucuronide and sulfate conjugates) were observed
Elimination: X-vir is widely excreted by the kidney with urinary unchanged drug recovery ranging from 62% to 73%.
Terminal elimination half life of X-vir 24 hours.
In Depth Information on X-vir Tablet:
Expert Advice for X-vir Tablets
- When use of nucleoside analogues alone or with combination of antiretroviral ,the lactic acidosis and severe heptomegaly with steatosis involves in reporting fatal cases.
- Discontinuation of anti hepatitis therapy which leads to severe acute exacerbations of hepatitis B have been reported
- In pregnancy category, proper care should be taken due to no data available on tranamission of HBV from mother to infant by the X-vir drug effect.
If patient under treatment of X-vir, avoid breast feeding
Special Warnings of X-vir Tablets
Alcohol interaction with the drug is not known. Please consult your doctor for any inconveniency.
Pregnancy category C: X-vir 1mg may not be safe to use during pregnancy. In studies of animal reproduction has shown adverse effects on the fetus, in human studies has no adequate and well controlled data but probable benefits may permit to use the drug in pregnant women against possible risks.
While breastfeeding, taking into account of serious of the drug to the mother an decision should be made to discontinue the drug or discontinue breastfeeding. Excreted into human milk is unknown and in animal milk its excreted.
X- vir 1mg cause side effects of dizzy, sleepy, tried or reduce alertness. If this you feel then avoid driving until you feeling well.
Patient with kidney problem use the X-vir 1mg with caution. Dosage adjustment is required in renal impairment. Please consult the doctor for further clarifications.
Patient with hepatic impairment have no dosage adjustment is Necessary IN X-vir 1mg tablets
If you missed a dose take it as soon as possible, if time reach for next dose, then skip missed dose and continue regular schedule. Do not take extra or double dose. Please consult our doctor.
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Brand Name : <--------------------> X-vir
Category : <--------------------> Hepatitis Drugs
Sub Category :<--------------------> Entecavir
Company Name :<--------------------> Natco
Ingeridents(Generic Name) :<--------------------> Entecavir
Tablets :<--------------------> 30 TABLETS
Package :<--------------------> 1X30
Strength :<--------------------> 1mg