Capnat


QUICK OVERVIEW

Generic Name : Capecitabine
Category : Anti-Cancer Drugs
Company Name : Natco pharma Ltd
Dosage Form : 100 tablets
Strength : 500mg

  

Availability: In Stock

Medicine Overview of Capnat


Uses of Capnat Tablet


Capnat 500mg is used with co administration with other medication for the treatment of breast cancer in women which has been relapsed with other medication and has not improved with other medication after the treatment.

Capnat 500mg is also indicated for the treatment of colon or rectal cancer which has become worse condition or spread to other body parts. The will prevent colon cancer from spreading in people after the surgery to remove tumor.

Side effects of Capnat Tablet


Common side effect of Capnat 500mg

Constipation

Feeling tried

Mild skin rash

Numbness or tingling in your hands or feets.

Sign of allgeric reaction: swelling of face, lips, tongue or throat

If you have any one of the symptoms, call your doctor at once:

Fever above 100.5 degrees

Decreased appetite, vomiting, nausea

Blisters or mouth ulcer, red gums

Swallowing difficulty

Tenderness in hands or feets

Dehydration symptoms

Heart problems: chest pressure, irregular heartbeat, shortness of breath

Kidney problem: no urinating, painful urination, swelling in feet or ankles.

Liver problem: upper stomach pain, itching, decreased appetite, clay colored stool, jaundice

How to use Capnat Tablet

  • Adult dose for Capnat to treat colorectal cancer

First line treatment for the patients with metastatic colorectal cancer when treated with fluoropyrimidine alone is preferred dose is 1250 mg/m2 given orally twice daily (morning or evening) administrated as 3 week cycles ( 2 weeks followed by a l week rest period)

  • In patients with DUKES C colon cancer by adjuvant treatment preferred dose is 1250 mg/m2 given orally twice daily (morning or evening) administrated as 3 week cycles ( 2 weeks followed by a l week rest period) for a 8 cycles total ( 24 weeks).

  • Adult dose for Capnat to treat breast carcinoma

The prescribed dose is 1250 mg/m2 given orally twice daily (morning or evening) administrated as 3 week cycles ( 2 weeks followed by a l week rest period) as a 1 hour IV infusion with combination of docetaxel 75mg/m2.

  • Capnat in combination with docetaxel:

The prescribed dose is 1250 mg/m2 given orally twice daily (morning or evening) administrated as 3 week cycles ( 2 weeks followed by a l week rest period).

OVERDOSAGE: Acute overdose with Capnat will includes vomiting, diarrhea, gastrointestinal irritation and bleeding. If an overdose suspected, seek emergency medical attention.

 

How to Capnat Tablet works:


Converstion of capecitabine to  5- fluorouracil (5- FU) is carried out by an enzymes.  Normal cells and cancer cells are metabolized in 5- FU to FdUMP ( 5- fluoro- 2- deoxyuridine monophosphate and FUTP ( 5- fluorouridine triphosphate). By two different mechanism the metabolites cause cell injury. Firstly to form a covantly bound ternary complex the FdUMP and the folate cofactor, N5- 10-methylenetetrahydrofolate will bind to thymidylate synthase. By this binding, It may inhibits the formation of thymidylate from 2- deoxyuridylate. Thymidylate is an important  messenger of thymidine triphosphate that is essential for the DNA synthesis. Hence the compound deficiency will blocks the cell division.

Secondly, mistakenly FUTP is incorporate in place of uridine triphosphate (UTP)during RNA synthesis. Additionally, FUTP interferes w/ RNA processing and protein synthesis by metabolic error.
 

Absorption: Readily absorbed. Food decrease rate and extent of absorption. peak plasma concentration is 1.5hr.

Distribution: Plasma protein binding: <60%, mainly to albumin.

Metabolism: capecitabine hydrolysed in the liver into 5'-deoxy-5-fluorocytidine (5'-DFCR) then to 5'-deoxy-5-fluorouridine (5'-DFUR), and subsequently in body tissues into 5-fluorouracil by thymidine phosphorylase enzyme.

Excretion: Via urine (96%, (<3% as unchanged drug) and faeces (<3%). Elimination half-life is 0.75 hr.


In Depth Information on Capnat Tablet:


Expert Advice for Capnat Tablets


Inform the doctor or  pharmacist about allergic condition against Capnat if you had, fluorouracil (Adrucil, 5-FU), any another regimens, or any of the compound  in capecitabine tablets.

Information about other prescription drugs and nonprescription medications, vitamins, nutritional supplements, and herbal products that taking or plan to take. Like phenytoin (Dilantin), leucovorin, and folic acid (in multivitamins) inform the doctor piror to the treatment than the doctor may require to change the doses of your drug or monitor you carefully for side effects.

 You have been  previously taking or ever had DPD( dihydropyrimidine dehydrogenase)  deficiency of enzyme .  Inform the doctor about this then your doctor may preferably  inform you avoid taking capecitabine.

Inform the doctor that you have or have ever had renal, hepatic, or cardiac problem

Inform the doctor that are you pregnant or plan to become pregnant. Avoid planning to have children while on treatment with capecitabine. You should use a essential  method of  conceiving to prevent pregnancy in yourself or your partner during your treatment with capecitabine. The  drug will harm the fetus.

Avoid breast feeding while on treatment with capecitabine


Special Warnings of Capnat Tablets


Alcohol

Alcohol interaction with Capnat 500mg is not known. Please consult the doctor

Pregnancy

Capnat 500mg have pregnancy category D have described that animal or human studies shown fetal abnormalities and cause harm to the fetal, hence Capnat is unsafe to use  during pregnancy clearly. Capnat 500mg  is contraindicated in pregnant women or to become pregnant and in men the drug causes regressive changes in the testes including reduces the number of spermatocytes and spermatids.

Lactation

Capnat 500mg is excreted into breast milk taking account on this, discussion should done on whether to discontinue the breast feeding or the drug. Use of drug is contraindicated during breastfeeding. It is unclear the effect of new born babies

Driving

Capnat 500mg will affect the ability of driving due to its side effects. Avoid driving unless you feeling well.


Kidney

Capnat 500mg used with caution in patients with severe renal disease, dose adjustment is required and limited data is available on the tablets in mild, moderate kidney problem, no dose adjustment is necessary .Please consult doctor.

Liver

 The patient with severe liver disease should  Capnat 500mg with caution. Limited information of the drug in mild to moderateliver disease. No dose adjustment is needed. Please consult with doctor.



Missed Dosage

If you missed a dose take it as soon as possible, if time reach for next dose, then skip missed dose and continue regular schedule. Do not take extra or 2 dose at a time. Please consult with doctor

 


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Capnat

 
Brand Name : <--------------------> Capnat
Category : <--------------------> Anti-Cancer Drugs
Sub Category :<--------------------> Capecitabine
Company Name :<--------------------> Natco pharma Ltd
Ingeridents(Generic Name) :<--------------------> Capecitabine
Tablets :<--------------------> 100 tablets
Package :<--------------------> 10X10
Strength :<--------------------> 500mg

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