Sorafenat


QUICK OVERVIEW

Generic Name : Sorafenib
Category : Anti-Cancer Drugs
Company Name : Natco pharma Ltd
Dosage Form : 120 tablets
Strength : 200mg

  

Availability: In Stock

Medicine Overview of Sorafenat


Uses of Sorafenat Tablet


  • Sorafenat 200mg used to treat the hepatocellular carcinoma
  • The Sorafenat 200mg tablet is used for the Treatment of advance renal cancer.
  • Sorafenat 200mg  is indicated to treat the patients with advanced carcinoma refractory to radioactive iodine (metastatic thyroid cancer)

Side effects of Sorafenat Tablet


Common Side EffectsAcne ; Dry skin ; Nausea ; Itching or rash skin ; Vomiting, ; Diarrhea ; Patchy hair thinning, ; Loss of appetite ; Stomach ache ; mouth dryness ; throat soreness ; Tiredness etc.

Serious Side Effects Bloody stools ; Coughing up blood / vomit ; fast heart rate ; low concentration ; Chest heavy feeling ; Sudden  weakness ; Increased blood pressure ; Severe skin problem; yellowing of the skin or eyes etc.

How to use Sorafenat Tablet

  • Sorafenat  recommended  dose  is 400 mg (2 x 200 mg tablets)
  • Sorafenat  administrated twice in a  day on empty stomach (at least 1 hour before or 2 hours after a meal).
  • Treatment should continue till the patient is not clinically benefiting from therapy.

Overdosage : sorafenat, incase suspected should be confidential and extra care should be taken. There is no particular treatment for Sorafenat overdose.

How to Sorafenat Tablet works:


Sorafenat   suppress the  surface of cell and intracellular kinase to delay  the growth of cancer   cells.   Sorafenat act as a biological treatment that is a protein kinase inhibitor. The protein kinase is an enzyme( chemical messenger). This enzyme enhance grow of tumour cells.

 Sorafenat work as a multi kinase inhibitor, Since Sorafenat blocks  protein kinase. Two way action by sorafenat tablet in which firstly target the protein which normally help to grow malignant cells and on other hand it helps to stop cancer cells forming from new blood vessels.

Absorption: bioavailability of sorafenat is 38-49% and the peak plasma level is 3 hours. It administrated without food.

Distribution: plasma protein binding is 99.5%

Metabolism: Sorafenat metabolized in liver by CYP3A4 and undergo oxidative metabolism and in glucuronidation  by UGT1A9.

Elimination: Excreted within 14 days of 96% dose in oral administration. In feces 77% and in urine 19% as glucuronidated.


In Depth Information on Sorafenat Tablet:


Expert Advice for Sorafenat Tablets


  • Inform  doctor and pharmacist if you are allergic to sorafenat or, any another drugs, or any of the ingredients in Sorafenat tablets.
  • Inform the  doctor if you have hepatic carcinoma  and getting treatment with carboplatin  and paclitaxel  or gemcitabine  and cisplatin . The doctor will prohibits  not to take Sorafenib if you have lung cancer and you are rgetting  these medications.
  • Inform the doctor about the  herbal supplements you are taking,
  • Inform the doctor before taking Sorafenat that having high blood pressure, bleeding problems, chest discomfort, cardiac disease, kidney disease other than kidney cancer, or liver disease.
  • While using this medicine, the fertility in men is decreased. So discuss with doctor about the risk of medicine
  • Inform the  doctor if you are breast-feeding or plan to breast-feed. Avoid  breast-feed while on treatment with Sorafenat.

Special Warnings of Sorafenat Tablets


Alcohol

Alcohol interaction is unknown. Please consult with the doctor.

Pregnancy

Category D: Sorafenat can harm to an unborn baby and cause injury and even death to the unborn baby if you treatment during the 2nd and 3rd  trimesters of pregnancy.  if you are pregnant do not use the Sorafenat medicine without the knowledge of your doctor.

Lactation

It is not known that this medicine passes into breast milk or could harm a new born  baby. Do not use Sorafenat medication ,if your breast feeding.

Driving

While taking the Sorafenat 200mg  during driving, it is safe and will not affect the ability of drive


Kidney

Sorafenat 200 mg tablet is safe to use in patients with mild moderate  kidney disease. No dosage adjustment required for patients. In patients with severe kidney disease limited use with caution.

Liver

No dosage adjustment required in patients with baseline mild liver disease. Avoid using of  Sorafenat while patients with baseline severe hepatic impairment . Dose adjustment may be required. Please consult with your doctor



Missed Dosage

The drug dose is missed, then take the drug dose as soon as possible. If next dose time arrived then skip the missed dose and continue the routine schedule. Avoid taking extra dose or 2 dose at one time. Please consult your doctor for further clarification.


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Sorafenat

 
Brand Name : <--------------------> Sorafenat
Category : <--------------------> Anti-Cancer Drugs
Sub Category :<--------------------> Sorafenib
Company Name :<--------------------> Natco pharma Ltd
Ingeridents(Generic Name) :<--------------------> Sorafenib
Tablets :<--------------------> 120 tablets
Package :<--------------------> 1X120
Strength :<--------------------> 200mg

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