Generic Name : Rituximab
Category : Anti-Cancer Drugs
Company Name : Intas Pharmaceuticals Ltd
Dosage Form : 1 bottle
Strength : 100mg


Availability: In Stock

Medicine Overview of Mabtas-100mg

Uses of Mabtas-100mg Tablet

Mabtas 100mg injection and hyaluronidase human injection  are given alone or combination with another drugs  to treat certain types of non-Hodgkin's lymphoma and chronic lymphocytic leukemia (cancer start in WBC).

Mabtas 100mg injection is also used with methotrexate (Otrexup, Rasuvo, Xatmep, others) for the treatment  rheumatoid arthritis symptoms  in adults that have been  already treated with a some type of  regimen knowns as tumor necrosis factor (TNF) inhibitor.

Mabtas 100mg injection is a type  in a classification of drugs called monoclonal antibodies. 

Mabtas 100mg injection  is used to killing cancer cells to treat NHL , CLL,  rheumatoid arthritis, granulomatosis with polyangiitis, and microscopic polyangiitis by stopping the activity of the part of the immune system which can damage the joints, veins, and other blood vessels and cause damage to organs (heart and lungs).

Side effects of Mabtas-100mg Tablet

Common effects: fever and chills (flu lik symptoms)

Less common side effects:

Weakness; nausea ; headache; cough ; dyspnea ; pharyngitis

How to use Mabtas-100mg Tablet

Mabtas 100mg injection is recommended to administer only through intravenous infusion not by IV push or bolus.


  • First infusion:   initially rate of 50 mg/hr is given , in not showing infusion toxicity, rate rised upto 50 mg/hr increments at intervals of 30 min and max of 400 mg/hr.

  • Successive infusion:  start at rate of 100 mg/hr, in not showing infusion toxicity, rate raised upto 100 mg/hr increments at intervals of 30 min and max of 400 mg/hr.

  • Premedication with corticosteroids must be considered, if Mabtas injection combination with CHOP chemotherapy is not given.


 Dose is 375 mg/m2 as an IV infusion.

  • Relapsed treatment : once weeks for  4 or 8 doses administrated.

  • Retreatment for relapsed :  once weekly for 4 doses administrated.

  • Previously untreated : administer on day 1 of each cycle of chemotherapy, upto8 doses. In complete or partial response of patient, start with 8 weeks for maintenance following Mabtas in combination with chemotherapy completed then administer 8weeks for 12 dose as a single agent.

  • Non – progression ( following CVP chemotherapy completion 6 – 8 cycles):  once weekly for 4 dose at intervals of 6 months and max of 16 dose.

  • Diffuse large B- cell NHL : on day 1 each cycle of chemotherapy upto 8 infusions.


Before starting of FC chemotherapy, dose recommended is 375 mg/m2 followed 500 mg/m2 on day 1 of 2-6 cycles every 28 days.


  • Mabtas infusion about 250 mg/m2 within 4 hours prior to the administration of Indium-111-(In-111-) Zevalin and  Yttrium-90- (Y-90-) Zevalin.

  • Rituxan and In-111-Zevalin 7–9 days before to Rituxan and Y-90- Zevalin administrated.


  • Mabtas injection is administer with methotrexate combination

  • Mabtas injection administrating as two dose of 100mg IV infusion 2 weeks separated.

  • When glucocorticoids administered as methylprednisolone 100mg IV

  • Successive course based on clinical evaluation must administer every 24 weeks,but not early than every 16 weeks.


  • Dose of 375 mg/m2 IV infusion weekly once for 4 weeks.

  • When Glucocorticoids treat with methylprednisolone by dose of 1000 mg IV/ day for 1- 3 days and purse by oral prednisone 1 mg/kg/day  are recommended for the treatment of symptoms of  serious vasculitis . This drug should intiate within 14 days before or with the starting of Mabtas injection and may continue during and after the 4 week course with treatment of Mabtas injection.

  • Safety and not established for subsequent infusion.

Take an Mabtas injection amount and diluted to final concentration of 1 mg/ml upto 4 mg/ml as infusion  (containing either 0.9% Nacl or 5% dextrose in water). Invert gently the bag and mix the solution. Dispose unused drug left in vial.

OVERDOSAGE: If overdosage occurs seek immediately to the emergency department or poison control help line. Please consult the doctor for further clarification.

How to Mabtas-100mg Tablet works:

Mabtas 100mg injection is a type of class called as monoclonal antibody. Its an new type of "targeted" cancer treatment and an integral part of the body's immune system. The body naturally build antibodies in associated to an antigen that has entered the body and attach to the antigen for destruction by the immune system.

Specific cells only targeted by monoclonal antibiotics, they may cause less toxicity to healthy cell and it is usually treatment recommended only for cancers in which antigens (and the respective antibodies) have been already identified.

Mabtas 100mg injection works by linking to the CD20 antigen on normal and malignant B-cells.  There by body's natural immune security are initiated to attack and kill the marked B-cells.  Stem cells i.e young cells in the bone marrow which will grow into the various cell types and do not have the CD20 antigen.  CD20 antigen allows healthy B-cells to reproduce after treatment.

Absorption: Not available

Distribution: no plasma protein binding and volume of distribution is 3.1 L

Metabolism: Mabtas 100mg injection metabolized by human antimurine antibody production.

Elimination : not available

Terminal elimination of half life of NHL is 22 days and for RA is 18.0 days, GPA and microscopic polyangitis is 23 days

In Depth Information on Mabtas-100mg Tablet:

Expert Advice for Mabtas-100mg Tablets

  • Allgeric condition against Mabtas 100mg injection or any other medication inform your doctor.
  • Regarding your past medical drug used which include in prescription, non-prescription, vitamins & supplements , nutritional products just inform the doctor.
  • While using Mabtas 100mg injection do not take any vaccination or immunization without taking advice from doctors.
  • Avoid use of Mabtas 100mg injection if you are pregnant. It will harm the baby unborn, while using Mabtas injection use correct birth control to prevent pregnancy and for at least 2 weeks after your treatment ends. Mabtas injection may affect the ability to have children in women. Inform your doctor if you planning to pregnant.
  • It is unknown whether Mabtas 100mg injection passes into breast milk , avoid breast-feed while on Mabtas injection treatment.
  • Discard the unused drug by asking the advice from doctor or pharmacist.

Special Warnings of Mabtas-100mg Tablets


Mabtas 100mg injection interaction with alcohol is unknown. Please consult with the doctor.


Category C : Animal studies reproduction shown an adverse effect on the fetus.  There is no sufficient and  well controlled studies in humans, using in pregnant women benefits by warrant use of the drug.


Mabtas 100mg injection excreted into human milk is unknown. Because the drug is a large protein molecule, no information is available. Women should not breast feed during Mabtas injection treatment and 12 months following last dose.


The action of Mabtas 100mg injection while driving is unknown whether it will affects the driving abilty. If you experienced any symptoms of side effects then avoid driving until you feeling well.


Mabtas 100mg injection using in patients with kidney disease is probably safe. Mabtas injection has limited data on dose adjustment may not be necessary in these patients. Please consult the doctor.


Mabtas 100mg is not prescribed in patients with the active hepatic problem or patients having viral hepatitis as it infection can reactivate. Limited  data available on patients with liver disease. Please consult the doctor.

Missed Dosage

If you missed a dose take it as soon as possible, if time reach for next dose, then skip missed dose and continue and continue the regular schedule. Do not take extra or 2 dose at a same time.


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Brand Name : <--------------------> Mabtas-100mg
Category : <--------------------> Anti-Cancer Drugs
Sub Category :<--------------------> Rituximab
Company Name :<--------------------> Intas Pharmaceuticals Ltd
Ingeridents(Generic Name) :<--------------------> Rituximab
Tablets :<--------------------> 1 bottle
Package :<--------------------> 1x1
Strength :<--------------------> 100mg




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