Votrient-400mg


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QUICK OVERVIEW

Category : Anti-Cancer Drugs
Generic Name : Pazopanib
Brand name : Votrient
Company Name : Novartus
Tablets : 30 TABLETS / Package : 1X30
Strength : 400mg

  

Availability: In Stock

Medicine Overview of Votrient-400mg


Votrient-400mg Description


Votrient (pazopanib) is  a type of protein kinase inhibitors. It is also indicated for the treatment of advanced kidney cancer and soft tissue sarcoma.

Votrient 400MG is an antineoplastics medications which interfere with the development and spreadness of cancer cells in the body.


Uses of Votrient-400mg


Votrient 400MG  is used as a single agent to treat the renel cell carcinoma and its advanced stage It works by preventing the activity of proteins which are interferes with the growth and spread of cancer cells.

Votrient 400mg is also used  as a single regimen to treat the Soft Tissue Sarcoma, (a type of cancer that occurs in  the supportive tissue of the body).  The cancer can develop in muscles, blood vessels, fat tissue or in other tissues that support, surround and protect organs

Side effects of Votrient-400mg


Votrient 400mg has certain side effects, If any of the symptoms occrs or not cured then call the doctor immediately

Major side effects: Diarrhae; High blood pressure; low WBC; Elevated liver function test; Blood test abnorm200mgalities; increased in bilirubin levels.

Common Side effects: Nausea; loss of  appetite; fatigue; blood test abnormalities (low magnesium, low glucose); weakness, stomach ache.

How to use Votrient-400mg


  • Votrient 400mg dosage for kidney carcinoma and soft tissue sarcoma will be initially 800mg .Patients on strong CYP3A4 inhibitors. Dose  reduced to 400 mg once daily
  • Votrient 400mg should be taken on a empty stomach (1hr before or 2hr after meals.
  • Swallow the medicine whole don’t chew/crush.
  • Food interaction :Avoid  grapefruit juice or grapefruit juice.

OVERDOSAGE: Votrient doses upto  2000mg can be administrated and It is evaluated in clinical trials and treatment of overdose with votrient should consist of supportive measures and there is no specific antidote.

How to Votrient-400mg works


Votrient 400mg  is an potent protein kinase  inhibitor and selective multiple receptor tyrosine kinases (RTKs) that are described in beginning of signal transduction pathways that ready  for reproduction of cancer cells and affect processes critical to cell survival and tumur progression. RTKs comes in the blockage and involves the receptors for vascular endothelial growth factors (VEGFR-1, -2, and -3), platelet-derived growth factors (PDGFR-α and -β), and stem cell factor.

Absorption: Pazopanib 400mg  partially absorbed from the GI tract. And votrient with food has greater absorption Bioavailability is 14-39%. Time  of peak plasma concentration: 2-4 hr.
Distribution: Human Plasma  binding of Pazopanib 400mg is >99%.
Metabolism: Mainly in the liver Pazopanib 400mg metabolized  by CYP3A4 enzyme and to a lesser extent by CYP1A2 and CYP2C8 enzymes.
Elimination: Pazopanib primarily  excreted through faeces approx 82%, 67% as unchanged drug and urine (<4%)with renal elimination.

Terminal Elimination half-life: Approx 31 hr.


In Depth Information on Votrient-400mg


Expert Advice for Votrient-400mg


Consult the doctor before to the treatment of Votrient 400mg tablets about:

  • Allgeric to pazopanib or any other drug products of pazopanib, which include in prescription, over the counters,vitamins,herbal remedies.
  • Do not take immunization or vaccination without doctors advice.
  • Inform your doctor about pregnancy and planning to pregnant.
  • Do not breast feed while treatment with Votrient

Special Warnings of Votrient-400mg


Alcohol

Alcohol interaction with Votrient 400mg is not known. Please consult the doctor

Pregnancy

Category D: Votrient 400mg  show  positive in human fetal effects, but the benefits from  use in pregnant women may be acceptable against the risk .

Lactation

Votrient 400mg usage is not recommended in pregnant women and the expert advice to either discontinue breastfeeding or the drug, in order to give  importance of drug to the mother. Excretion into human milk and effects in the newborn baby is unknown.

Driving

While taking Votrient 400mg dizziness occurs, It will affect the ability of driving. Avoid driving unless you feeling well.


Kidney

When patients with mild ,moderate kidney disease no adjustment recommended in tablet Votrient 400mg. Patients with severe kidney problem or ESRD use with caution is recommended.

Liver

Votrient 400mg has no dosage adjustment is necessary in mild or severe renal impairment. Caution recommended in moderate liver disease in patients.



Missed Dosage

If you missed a dose take it as soon as possible, if time reach for next dose, then skip missed dose and continue regular schedule. Do not take extra or 2 dose at a time. Please consult with doctor.


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Votrient-400mg

 
Brand Name : <--------------------> Votrient-400mg
Category : <--------------------> Anti-Cancer Drugs
Sub Category :<--------------------> Pazopanib
Company Name :<--------------------> Novartus
Ingeridents(Generic Name) :<--------------------> Pazopanib
Tablets :<--------------------> 30 TABLETS
Package :<--------------------> 1X30
Strength :<--------------------> 400mg

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