Sovihep-Dacihep


QUICK OVERVIEW

Category : Hepatitis Drugs
Sub Category : Sofosbuvir-Daclatasvir
Brand name : Sovihep-Dacihep
Generic Name : Sofosbuvir + Daclatasvir
Company Name : Hetero
Tablets : 28 Tablets / Package : 3x28
Strength : 400mg+60mg

  

Availability: In Stock

Medicine Overview of Sovihep-Dacihep Tablet


Uses of Sovihep-Dacihep Tablet


Sovihep plus dacihep is an direct acting antiviral drug which contain active ingredients of Sofosbuvir 400mg and daclatasvir 60mg and with or without ribavirin is indicated for the treatment of chronic hepatitis C virus genotype 1 or 3 infection.

Side effects of Sovihep-Dacihep Tablet


 When administrating Sovihep plus dacihep with combination with amiodarone will cause some side effects on heart and seek medical help if you have:

Decreased heartbeat

Difficulty in breathing, Chest discomfort

Lightheadness

Serious side effects:

Loss of Memory and confusion

Severe vertigo

Severe weakness

Common effects:

Head pain

Triedness.

How to use Sovihep-Dacihep Tablet


 Sovihep plus dacihep is an antiviral drug for treatment of chronic Hep C virus and the dose recommended is Sofosbuvir 400mg and daclatasvir  60mg which is administrated via oral route once in a day and given with or without food.

Sovihep plus dacihep administrated for patients with compensated cirrhosis or without cirrhosis for 12 weeks and combined with ribavirin used with decompensated cirrhosis and posttransplant for genotype 1

Sovihep plus dacihep without cirrhosis for 12weeks. Sofovir , Daclahep  and ribavirin combination used for compensated or decompensated ( child-pugh B or C) cirrhosis and Posttransplant for 12weeks for genotype 3.

Overdose of Sovihep and Dacihep: No specific antidote available, If overdose occur, patient should be monitor the development of toxicity and supportive and symptomatic care should be monitor. Seek medical emergency or call poison control for immediate treatment

How to Sovihep-Dacihep Tablet works:


Sofosbuvir is an antiviral drug and called as nucleotide polymerase inhibitor. Sofovir reveal to have a high barrier to the development of resistance and inhibits the hep C NS5B protein. And also inhibits the  RNA polymerase enzyme by the cellular worker which will performs the multiplication process, Hence it stops the replication of Hepatitis C virus and decrease the amount of Hep C virus in liver. Sofovir also acts to reduce damage in liver and improves function in liver.

Daclatasvir is a direct acting antiviral drug which is used for the patient affected by hepatitis c virus infection. It will targets the Hepatitis C virus and blocks the numerous steps in reproduction process of HCV by the way it interfere with the virus particles from making copies themselves, and  helps the body to remove virus  from the blood.

  Absorption:- Sovihep peak plasma concentration of obtained at -0.5 to 2 hr post dose and where as In Dacihep, peak plasma concentration is within 2 hours post dose and bioavailability is 67%

Effect of food:.  Sovihep is administrated without food is effective. In Dacihep drug either  taken with food  nor without food.

Distribution: Sovihep is approx 51-65% bound to human plasma proteins and in Dacihep , the plasma protein binding is 99%

Metabolism:  :  Sovihep is broadly metabolized in liver (4% and >90%) to convert into pharmacologically active nucleoside analog triphosphate GS-461203. Dacihep metabolism based on the substrate of CYP3A with primry CYP isoform

Elimination:  Sofosbuvir elimination in urine 80%, feces 14% and 2.5%expired air. While single dose administration , Daclatasvir elimination of radioactivity was recovered 88% via feces and 6.6% via urine

Half life of Sofosbuvir and GS-331007 were 0.4 and 27hrs and Daclatasvir has  half life elimination of 12 to 15 hours


In Depth Information on Sovihep-Dacihep Tablet:


Expert Advice for Sovihep-Dacihep Tablets


Combination of Sovihep plus dacihep and amiodarone may cause bradycardia

Drugs should given with prescription only, without prescription drugs should not be issued.

Inform your healthcare providers that you are allergic to daclatasvir, Sofosbuvir or  have any other allergies before using the medicine. It may composed of inactive ingredients, that can  be cause allergic problems or other reaction. Talk to your pharmacist for more details.

If you had any  kidney disease, liver disease other than hepatitis C, inform your consultant about past medical history before having daclatasvir / Sofosbuvir.


Special Warnings of Sovihep-Dacihep Tablets



Alcohol


Alcohol interaction with Sovihep plus dacihep combination is unknown. Please consult with doctor.

Pregnancy


Pregnancy category B for Sovihep plus dacihep combination, In all trimester there are no adequate and well tolerated studies in pregnant women, Since animal reproduction trial has no risks and adverse effect to the fetus. But  with ribavirin combination,pregnancy category X cause to birth defect  and death to the fetus. Avoid combination therapy during pregnancy.

Lactation


Sovihep plus dacihep excreted into human milk is unknown, therefore its recommended that mother should not breast feed during Sovihep plus dacihep combination treatment.

Driving


While using Sovihep plus dacihep combination you may get dizziness, weakness and confusion and make tried. So avoid driving until you feeling well. Please consult with doctor



Kidney


No dosage adjustment recommended with mild , moderate kidney problem and limited information about this drug. So please consult with doctor and inform him before taking Sovihep plus dacihep tablet.

Liver


Sovihep plus dacihep administration, patients with mild , moderate and severe dysfunction has no dosage adjustment. Please consult with your doctor.



Missed Dosage


If you missed a dose take it as soon as possible, if time reach for next dose, then skip missed dose and continue regular schedule. Do not take extra or 2 dose at a time. TAKE ADVICE FROM THE DOCTOR



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Sovihep-Dacihep

 
Category: --------------------Hepatitis Drugs
Sub Category:-------------------- Sofosbuvir-Daclatasvir
Brand name:-------------------- Sovihep-Dacihep
Ingeridents(Generic Name) :-------------------- Sofosbuvir + Daclatasvir
Package:-------------------- 28 Tablets/3x28
Strength :-------------------- 400mg+60mg

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