Category : Hepatitis Drugs
Sub Category : Sofosbuvir-Ledipasvir
Brand name : Ledifos
Generic Name : Sofosbuvir + Ledipasvir
Company Name : Hetero
Tablets : 28 Tablets / Package : 3x28
Strength : 400mg + 90mg


Availability: In Stock

Medicine Overview of Ledifos Tablet

Uses of Ledifos Tablet

Ledifos  90mg/400mg used for  long lasting a viral infection of the liver  “Hepatitis C”( a chronic condition). By combination therapy, It is used with other antiviral drug(ribavirin). Ledifos tablet minimize the amount of hepatitis C virus in body in which help to improve immune system by fighting against infection and also recover the liver infections

Side effects of Ledifos Tablet

Ledifos ranges from mild to severe condition and risk can varies from person to person.

Memory loss

Breathing difficulty

Chest discomfort

Low heartbeat

Weakness & head pain


Common Side effects: lack of appetite ; diarrhea ; myalgia ; dizziness ; Cough ; discouragement

How to use Ledifos Tablet

Ledifos tablet is indicated for chronic hepatitis C viral infection.

In adult dose recommended is ledipasvir 90mg and Sofosbuvir 400mg of one tablet, once in a day. Ledifos can be given with or without food for 12weeks duration.

For genotype1,4,5 and 6 : Treatment of new or experienced patients without cirrhosis or with compensated cirrhosis used with coexistent ribavirin in eligible patients for 12 weeks.

For genotype 1 and 4 : liver transplant recipients for new or experienced patients without cirrhosis or with compensated cirrhosis used with coexistent ribavirin in eligible patients for 12 weeks.

Geriatric dose : same as adult dose.

Pediatric dose: 1 tablet of Ledifos 90m/400mg once daily for children and adolescents ≥ 12 years or weight ≥35kg.

Overdose: ledifos overdose has no specific antidote available.If occurs should monitored for evidence of toxicity or seek to emergency medical attention or call the poison help line Contact 1-800-222-1222.

How to Ledifos Tablet works:

Ledifos 90mg/400mg  has an capability of direct prevent the multiplication of hepatitis C virus by its own. It has a fixed dose combination of  2 direct acting antiviral drug . Because of both drug combination,it targets different stages in cycle. Ledipasivir , an NS5A inhibitor which works by prevent by a protein needed to finish the life cycle of Hep C virus in the liver cell, and the other Sofosbuvir is a nucleotide polymerase,in turn prevent the replication of  virus’s genetic material. Sofosbuvir blocks the new production of  HCV.

Absorption: Well absorbed and peak plasma concentration of ledipasvir is 4 – 4.5 hr post dose and Sofosbuvir is 0.8 -1 he post dose.

Distribution: Plasma protein binding of ledipasvir >99.8% and Sofosbuvir is 61% to 65%

Metabolism: Ledipasvir metabolism was observed by human is CYP1A2,CYP2C8,CYP2C9,CYP2C19,CYP2D6,CYP3A4

Primarily Sofosbuvir mobilized in the liver in the forms of pharmacologically active nucleoside analog triphosphate GS-461203.

Excretion: Ledipasvir elimination via feces (-86%) and urine (1%) and for Sofosbuvir via urine (80%) and feces (14%).

Half life elimination of Ledipasvir is 47hrs and Sofosbuvir is -0.5hrs.          

In Depth Information on Ledifos Tablet:

Expert Advice for Ledifos Tablets

The treatment of Hepatitis C for most of the patient,Ledifos is high curing medicine.In some we cannot use this drug.

Avoid ledifos, If patient on treatment of ledipasvir or sofobuvir and other combination contain sofobuvir.

 Inform doctor in some cases before  using Ledifos

If pregnant or planning  or breast feeding

If taking prescription /nonprescription/herbal drug/nutritional supplements

If allergy to other medicine or food

If patient affected by kidney or liver problem

Special Warnings of Ledifos Tablets


Ledifos 90/400mg interaction with alcohol is not specified. For further details please consult your physician.


Pregnancy category B: In studies of  Animal reproduction that  have been failed to described a risk to the fetus and have been shown Interferon’s have Abortifacient effects, there are no adequate and well-controlled studies in pregnant women.Ledifos 90/400mg with Ribavirin will affect the Birth Defects and Fetal Death. Avoid in pregnant women and male partner. Patients should check Negative Pregnancy Test before starting the treatment. Use 2 Effective Methods Of Contraception and check monthly Pregnancy Tests.


Ledifos 90mg/400mg amount in human milk is very low and is highly bound to maternal plasma proteins. If mother require this drug then its not necessary to discontinue the drug. May be some doctor prescribe against breast feeding when its combine with ribavirin.


While using of Ledifos 90mg/400mg with combination of other antiviral drug will cause dizziness, blurred vision and may affect the ability to drive. Avoid using Ledifos during driving until you are feeling well.


Patient with  severe kidney disease, Ledifos 90mg/400mg should be used with caution and dose adjustment is required. Check up with doctor. When mild to moderate kidney disease, Ledifos 90mg/400mg do not require dose adjustment in those patients.


Mild, moderate or severe liver problem in patients have no dose adjustment, safe to use Ledifos 90mg/400mg with liver disease. But patient with decompensated cirrhosis using this drug plus ribavirin then clinical and hepatic monitoring is recommended.

Missed Dosage

As soon as you remember take the missed dose. If time for next dose then skips the missed dose and follow the routine scheduled. Do not take more than one tablet per day. Please consult your doctor for further details.

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Category: --------------------Hepatitis Drugs
Sub Category:-------------------- Sofosbuvir-Ledipasvir
Brand name:-------------------- Ledifos
Ingeridents(Generic Name) :-------------------- Sofosbuvir + Ledipasvir
Package:-------------------- 28 Tablets/3x28
Strength :-------------------- 400mg + 90mg




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