Ledihep


QUICK OVERVIEW

Category : Hepatitis Drugs
Sub Category : Sofosbuvir-Ledipasvir
Brand name : Ledihep
Generic Name : Sofosbuvir + Ledipasvir
Company Name : Hetero
Tablets : 28 Tablets / Package : 3x28
Strength : 400mg + 90mg

  

Availability: In Stock

Medicine Overview of Ledihep Tablet


Uses of Ledihep Tablet


Ledihep 90mg/400mg used for  long lasting a viral infection of the liver  “Hepatitis C”( a chronic condition). By combination therapy, It is used with other antiviral drug (ribavirin). Ledihep tablet minimize the amount of hepatitis C virus in body in which help to improve immune system by fighting against infection and also recover the liver infections.

Side effects of Ledihep Tablet


Ledihep 90mg/400mg ranges from mild to severe condition and risk can varies from person to person.

Common effects:

  • Appetite loss
  • strengthlessness
  • Difficulty to concentrate
  • Diarrhea 
  • irregular heartbeat
  • Weakness & head pain

Serious effects

  • Vertigo
  •  Discomfort in chest
  • Dyspnea
  • Loss of consciousness

How to use Ledihep Tablet


Ledihep 90mg/400mg  tablet is indicated for chronic hepatitis C viral infection.

In adult dose recommended is ledipasvir  90mg and Sofosbuvir 400mg of one tablet, once in a day. Ledihep can be given with or without food for 12weeks duration.

For genotype1,4,5 and 6 : Treatment of new or experienced patients without cirrhosis or with compensated cirrhosis used with coexistent ribavirin in eligible patients for 12 weeks.

For genotype 1 and 4 : Liver transplant recipients for new or experienced patients without cirrhosis or with compensated cirrhosis used with coexistent ribavirin in eligible patients for 12 weeks.

Geriatric dose : Same as adult dose.

Pediatric dose: 1 tablet of Ledihep 90mg/400mg once daily for children and adolescents ≥ 12 years or weight ≥35kg.

Overdose: Ledihep overdose has no specific antidote available.If occurs should monitored for evidence of toxicity or seek to emergency medical attention or call the poison help line Contact 1-800-222-1222.

How to Ledihep Tablet works:


Ledihep 90mg/400mg has an possibility of direct interfere with the proliferation of hepatitis C virus by its own. Ledihep a fixed dose combination of  2 direct acting antiviral drug . Because of both drug combinations, it targets different stages in cycle. Ledipasivir , an NS5A inhibitor which works by prevent by a protein needed to finish the life cycle of Hepatitis C virus in the liver cell, and the other Sofosbuvir 400mg  is an inhibitor of  nucleotide polymerase, in turn prevents  the replication of  virus’s genetic material. Sofosbuvir stops the new production of HCV.

  • Absorption: Well absorbed and peak plasma concentration of ledipasvir is 4 – 4.5 hr post dose and Sofosbuvir is 0.8 -1 he post dose.

  • Distribution: Plasma protein binding of ledipasvir >99.8% and Sofosbuvir is 61% to 65%

  • Metabolism: Ledipasvir metabolism was observed by human is CYP1A2,CYP2C8,CYP2C9,CYP2C19,CYP2D6,CYP3A4

  • Primarily Sofosbuvir mobilized in the liver in the forms of pharmacologically active nucleoside analog triphosphate GS-461203.

  • Excretion: Ledipasvir elimination via feces (-86%) and urine (1%) and for Sofosbuvir via urine (80%) and feces (14%).

  • Half life elimination of Ledipasvir is 47hrs and Sofosbuvir is -0.5hrs.


In Depth Information on Ledihep Tablet:


Expert Advice for Ledihep Tablets


The treatment of Hepatitis C for most of the patient, Ledihep is high curing medicine.In some we cannot use this drug.

  • Avoid Ledihep, If patient on treatment of ledipasvir or sofobuvir and other combination contain sofobuvir.

In some cases inform your doctor before using Ledihep

  • If pregnant or planning  or breast feeding
  • If taking prescription /nonprescription/herbal drug/nutritional supplements.
  • If allergy to other medicine or food
  • If patient affected by kidney or liver problem

Special Warnings of Ledihep Tablets



Alcohol


Ledihep 90mg/400mg interaction with alcohol is not specified. For further details please consult your physician.

Pregnancy


Pregnancy category B: In studies of Animal reproduction that  have been failed to described a risk to the fetus and have been shown Interferon’s have Abortifacient effects, there are no adequate and well-controlled studies in pregnant women. Ledihep 90mg/400mg with Ribavirin will affect the Birth Defects and Fetal Death. Avoid in pregnant women and male partner. Patients should check Negative Pregnancy Test before starting the treatment. Use 2 Effective Methods Of Contraception and check monthly Pregnancy Tests.

Lactation


Ledihep 90mg/400mg amount in human milk is very low and is highly bound to maternal plasma proteins. If mother require this drug then its not necessary to discontinue the drug. May be some doctor prescribe against breast feeding when its combine with ribavirin.

Driving


While using of Ledihep 90mg/400mg with combination of other antiviral drug will cause dizziness, blurred vision and may affect the ability to drive. Avoid using Ledihep during driving until you are feeling well.



Kidney


Patient with severe kidney disease, Ledihep 90mg/400mg should be used with caution and dose adjustment is required. Check up with doctor. When mild to moderate kidney disease, Ledihep 90mg/400mg do not require dose adjustment in those patients.

Liver


Mild, moderate or severe liver problem in patients have no dose adjustment, safe to use Ledihep 90mg/400mg with liver disease. But patient with decompensated cirrhosis using this drug plus ribavirin then clinical and hepatic monitoring is recommended.



Missed Dosage


As soon as you remember take the missed dose. If time for next dose then skips the missed dose and follow the routine scheduled. Do not take more than one tablet per day. Please consult your doctor for further details.



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Ledihep

 
Category: --------------------Hepatitis Drugs
Sub Category:-------------------- Sofosbuvir-Ledipasvir
Brand name:-------------------- Ledihep
Ingeridents(Generic Name) :-------------------- Sofosbuvir + Ledipasvir
Package:-------------------- 28 Tablets/3x28
Strength :-------------------- 400mg + 90mg

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