Medicine Overview of Sofovir Tablet
Uses of Sofovir Tablet
Sofovir is used to for the treatment of severe Hepatitis C virus in the liver, Hepatitis C virus is a long lasting infection of liver, Sofovir is highly effective medicine for this infection. Therefore it will decrease the action of hepatitis C Virus in our body and recover the liver from infection caused by virus.
Side effects of Sofovir Tablet
Common effects: Muscle pain; Energy loss; Rash and itchiness on skin; chronic insomnia; headache; weight loss; mental illness; fever; Diarrhae.
Major side effects: Skin yellowish; difficult to breath; pharyngitis; changes in behavior; Anemia
How to use Sofovir Tablet
Dose recommended for Sofovir medication is one tablet of 400mg OD (once daily) taken orally given along with food or without. Sofovir Duration for genotype 1 or 4 and 2 (CHC) is 12 weeks and Genotype 3 (CHC) is 24 weeks
How to Sofovir Tablet works:
Sofovir is a film coated tablet and type of DAA known as nucleotide polymerase inhibitor. Sofovir perform by Inhibiting enzyme RNA polymerase. Replication process is performed by the cellular workers(RNA polymerase). Sofovir stops the multiplication of virus and reduce the quanity of hepatitis virus in the liverReduce liver damage there by improve liver function
Absorption: Time to peak plasma concentration is -0.5 to 2hrs.
Distribution: Protein binding 61% to 65%.
Metabolism: Metabolized by hepatic, It form pharmacologically active nucleoside analog triphosphate GS-461203; by desphosphorylation results in formation of nucleoside inactive metabolite GS – 331007.
Excretion: Elimination via urine 80% as metabolite and in feces 14%.
Half life elimination is 0.4 hours
In Depth Information on Sofovir Tablet:
Expert Advice for Sofovir Tablets
- On treatment of Hepatitis C with Sofovir will require routine check up to their physician and blood check up to be followed..
- Sofovir should avoided during pregnancy because risk to unborn baby and birth defect occur.
- Allergic to Sofosbuvir alone, then inform your consultant.
- Sofovir combination with amiodarone may cause serious bradycardia.
- Sofovir treatment is not recommended in patient with severe kidney and liver disease.
- Avoid spreadness of infection via sexual contact, sharing needles or contact with blood during Sofovir 400mg treatment.
Special Warnings of Sofovir Tablets
Sofovir interaction with alcohol is unknown. If your are alcoholist please consult with doctor.
Sofovir pregnancy category B, In all trimester there are no adequate and well tolerated studies in pregnant women, Since animal reproduction trial has no risks and adverse effect to the fetus. But by combination with ribavirin, assigned a pregnancy category X leads to birth defect and death to the fetus. Avoid combination therapy during pregnancy
While breast feeding the drugs pass into breast milk is unknown, therefore its recommended that mother should not breast feed during Sofovir alone and combination treatment.
Sofovir when taken combination with other medicine for the treatment of hepatitis C, It will cause blurred vision ,dizziness and affect the ability to drive. Avoid driving if you are not feeling well.
Sofovir should be given with caution of severe kidney disease in patient. Adjustment of dose require for Sofovir 400mg Tablet. Please consult your healthcare professional. Information is less available on use of Sofovir 400mg in these patient and for mild to moderate kidney disease, no dose adjustment required in patient.
Sofovir 400mg is safe and efficacy in patients with liver disease. Dose adjustment is not required.
If you missed a single dose, consult your physician or take it as soon as possible within next dose reaches. Avoid taking extra or 2 dose at a time.takedoctor advice for further clarification.
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Category: --------------------Hepatitis Drugs
Sub Category:-------------------- Sofosbuvir
Brand name:-------------------- Sofovir
Ingeridents(Generic Name) :-------------------- Sofosbuvir 400mg
Package:-------------------- 28 Tablets/1x28
Strength :-------------------- 400mg