Medicine Overview of MyHep All Tablet
Uses of MyHep All Tablet
Myhep all 400mg/100mg is used to treat chronic Hepatitis C infection in adults. It fights against the infection and helps to improve immune system and easily recover of liver problem. Myhep all 400mg/100mg is indicated for the treatment of patients who are suffered with chronic hepatitis C viral infection associated genotype I, II, III, IV, V or VI infection without cirrhosis or with compensated cirrhosis. Myhep all with ribavirin use decompensated cirrhosis.
Side effects of MyHep All Tablet
Myhep all cause mild to severe side effects, it depends on each patient’s reaction to treatment.
Common side effects: Discouragement, sleeping and concentration in trouble, irritability, feeling empty, loss of strength, decreased appetite.
Serious side effects: Chest discomfort, dyspnea, irregular heartbeat, dizziness, unusual tiredness, unconsciousness.
How to use MyHep All Tablet
MyHep All is a fixed dose combination of Sofosbuvir 400mg and Velpatasvir 100mg
MyHep All dose will be differ for every patient. Follow the instruction given by your doctor don’t change until doctor advice.
MyHep All is for oral route of administration
For adult – one tablet once daily for 12weeks with or without food
Swallow the whole tablet, do not crush or chew, break it.
Patient With decompensated cirrhosis (child-pugh B or C) dose of MyHep All + ribavirin for 12weeks.
Patients Without cirrhosis or with compensated cirrhosis(child- pugh A)dose of MyHep All for 12 weeks.
Childern – safety and efficacy is not recommended.
IF OVERDOSE OCCURS: Myhep All has no specific antidote for overdose. If it occurs Urgently reach the patient to emergency medical or call poison help line and patient should under monitoring for evidence of toxicity and give supportive and symptomatic treatment immediately.
How to MyHep All Tablet works:
Sofosbuvir (Myhep All ) act has an nucleotide analog inhibitor, It will specifically interfere with HCV NS5B (non-structural protein 5B) RNA-dependent RNA polymerase and followed by intracellular metabolism to form the pharmacologically active uridine analog triphosphate (GS-461203), Sofosbuvir associates into Hepatitis C virus RNA by the NS5B polymerase and acts as a chain terminator . More specifically, Sofosbuvir ( Myhep All ) inhibits HCV viral reproduction by binding to the two Mg2+ ions include in HCV NS5B polymerase's GDD active site motif and interfere with further replication of HCV genetic material.
Velpatasvir is domino of NS5A inhibitors bind completely with RNA at this site. And also thought that NS5A inhibitors bind the target during its action in multiplication when the binding site is defined . Prevention of NS5A is also known to produce protein redistribution into lipid droplets. The role of NS5A in RNA reproduction is not yet clear.
Absorption: Oral administration, peak plasma concentration of Sofosbuvir is 0.5-1 hour after the dose and Velpatasvir peak plasma concentration is 3 hours after the dose
Administration of food with moderate fat or high fat meal both drugs (Sofosbuvir/Velpatasvir) increases the exposure Sofosbuvir (60 or 305 fat) and Velpatasvir (34 or21%) respectively
Distribution: human plasma protein binding of Sofosbuvir is 61-65% and Velpatasvir is >99.5% .
Metabolism: Sofosbuvir metabolized in liver by by GS-461203 and desphosphorylation leads to formation of GS-331007.Velpatasvir: Metabolized by CYP2B6, 2C8 and 3A4.
Elimination: Sofosbuvir major route is renal clearance via urine 80% and14% in feces and 2.5% in expired air. Velepatasvir major route is biliary excretion and dose eliminated 94% in feces and 0.4% in urine.
Half life of Sofosbuvir is 0.5hours, its GS-331007 is 25 hours and Velpatasvir is 15 hours.
In Depth Information on MyHep All Tablet:
Expert Advice for MyHep All Tablets
Consult with your doctor Before taking this Myhep all.
If you face any severe side effects also inform the doctor such as:
- Difficulty in concentrating
- Shallow breathing
- Rapid heart rate
- Reduce RBC
If you are taking the antacids, it is important for you to take them either four hours before or four hours after the Myhep all should consume either four hours before or 4 hours after the drug
Patient should inform the doctor in case taking the medication for heartburn or indigestion or any kind of ulcers [ H2 blockers]. Doctor may continue with these medicines or he will inform to change the drug 12 hour prior or 12 hours after before consuming Myhep all and same while using herbal drugs also. If you are pregnant or breastfeeding, inform doctor priorily.
Special Warnings of MyHep All Tablets
Alcohol interaction with Myhep all 400mg/100mg is unknown. Please consult with doctor for further details.
Animal studies failed to publish the effect of fetal harm, in human pregnancy there is no sufficient and controlled data about fetal harm. Myhep all 400mg/100mg with combination with ribavirin, it will harm unborn baby.
If the breast feed mother need this drug, no need of discontinue the breast feeding for this reason but some physician may suggest to stop during drug used with ribavirin. According to them use of drug is not recommended. Exretion into human milk is unknown and in animal milk is excreted.
On treatment with Myhep all 400mg/100mg , without feeling well do not go for drive because when Myhep all co administration with other medicine for treatment of hepatitis C, It may produce vertigo and blurred vision and also affect driving ability
Kidney problem with mild to moderate renal impairment have no dose adjustment required and patient with severe problem or ESRD require dose adjustments and use the Myhep all 400mg/100mg with caution. Please consult with doctor before using drug.
Myhep all 400mg/100mg is safe to use with hepatic problem. No dose adjustment required for those patient. For further information consult with your doctor. But for some patients liver function test should be monitor on treatment with Myhep all tablet.
As soon as you remember take the missed dose. If time for next dose then skips the missed dose and follow the routine scheduled. Do not take more than one tablet per day. Please consult your doctor for further details.
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Category: --------------------Hepatitis Drugs
Sub Category:-------------------- Sofosbuvir-Velpatasvir
Brand name:-------------------- MyHep All
Ingeridents(Generic Name) :-------------------- Sofosbuvir + Velpatasvir
Package:-------------------- 28 Tablets/3x28
Strength :-------------------- 400mg + 100mg