Medicine Overview of HepcDac Tablet
Uses of HepcDac Tablet
Hepcdac is an anti-viral drug which is useful for the treatment of chronic hepatitis C viral infection by preventing the multiplication of hepatitis C virus.Hepcdac is included to treatment of genotype III advanced hepatitis C virus in adults without cirrhosis
Generally Hepcdac tablets are not administrated alone, it may combined with other anti-viral medicines like Sofosbuvir, interferon and ribavirin
Side effects of HepcDac Tablet
Serious side effects Hepcdac 60mg
Digestive problem: decreased appetitie
Cardiovascular: symptomatic bradycardia, heart block, cardiac aeehythnias
Liver problems: increased ALT and AST, rise in total bilirubin
Musculoskeletal: myalagia, athralgia, back pain
Genitourinary : UTI
Central nervous system: headache, dizziness,migraine
Mental disorder: insomnia, irritability, anxiety
Ocular: dry eye
Common side effects Hepcdac 60mg
Allergic reaction, breathing difficulty, swelling of peripheral organs
Combination Hepcdac with amiodarone causes very slow heartbeat, chest pain, dyspnae.
How to use HepcDac Tablet
The doctor prescribe the Hepcdac 60mg based on age, past medical history and current status of diagnosis.
When combination with Sofosbuvir the dose recommended is one tablet of 60mg taken once in a day by oral route with or without food. Duration of treatment – 12weeks
Modification of dose : Reduce 30mg OD for strong CYP3A leads no Dose reduction. Increase dose to 90mg OD with moderate CYP3A leads to contraindicated.
For genotype 1 or 4 : treatment with daclatasvir +ribavirin+ peg IFN for 12 weeks
For genotype 2 : treatment with daclatasvir + ribavirin for 12 weeks
For genotype 3: treatment with daclatasvir + ribavirin (without interferon) for 24 weeks.
OVERDOSAGE: Hepcdac overdose has no particular antidote. Treatment will consist of supportive measures, involving monitoring of vitals and patient clinical status observation.
How to HepcDac Tablet works:
Hepcdac is a direct acting antiviral drug which is used for the patient affected by hepatitis c virus infection. It will targets the Hepatitis C virus and blocks the numerous steps in reproduction process of HCV by the way it interfere with the virus particles from making copies themselves, and helps the body to remove virus from the blood.
- Absorption: Poor absorption, peak plasma concentration is 2 hours post dose and bioavailability is 67%
- Distribution: while multiple dosing, plasma protein binding is 99%, on dialysis it significantly decrease the plasma binding and vol of distribution is 47L
- Metabolism: Daclatasvir is primarily metabolized through CYP3A4
- Elimination: Daclatasvir excreted through feces of (88%,53% unchanged) ; urine (6.6% primarily unchanged).
Terminal half life elimination is 12 – 15 hours
In Depth Information on HepcDac Tablet:
Expert Advice for HepcDac Tablets
Combination of Hepcdac 60mg and amiodarone may cause bradycardia
- Drugs should given with prescription only, without prescription drugs should not be issued.
- Inform your healthcare providers that you are allergic to daclatasvir ,Sofosbuvir or have any other allergies before using the medicine. It may composed of inactive ingredients, that can be cause allergic problems or other reaction. Talk to your pharmacist for more details.
- If you had any kidney disease, liver disease other than hepatitis C, inform your consultant about past medical history before having daclatasvir / Sofosbuvir.
Special Warnings of HepcDac Tablets
There is no data available for Hepcdac 60mg. Please consult your doctor
Pregnancy category for hepcdac is not predicted, when oral dose the animal studies have failed to explain the signs of fetal harm. There are no controlled data in human pregnancy. This drug should use with combination of other antiviral drug. Use of ribavirin containing regimen is contraindicated in pregnant women and the male partner. For some authorities, this drug should avoid during pregnancy.
Low amount of this drug in breast milk as Hepcdac 60mg is highly bound to maternal plasma protein, If the drug require for the feeding mother and it is not a reason for discontinue breastfeeding, If the drug using with ribavirin avoid breast feeding
While taking Hepcdac 60mg you will feel dizziness, difficulty in concentrating and vision problem this may affect your driving. So avoid driving till you feeling well.
There is no dosage adjustment recommended with renal dysfunction in Hepcdac 60mg tablet. Please consult with your doctor
When Hepcdac 60mg using in patients with mild, moderate or severe liver dysfunction has no dose adjustment recommended. Please consult with your doctor.
As soon as you remember take the missed dose. If time for next dose then skips the missed dose and follow the routine scheduled. Do not take more than one tablet per day. Please consult your doctor for further details.
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Category: --------------------Hepatitis Drugs
Sub Category:-------------------- Daclatasvir
Brand name:-------------------- HepcDac
Ingeridents(Generic Name) :-------------------- Daclatasvir
Package:-------------------- 28 Tablets/3x28
Strength :-------------------- 60 mg