Daclahep


QUICK OVERVIEW

Category : Hepatitis Drugs
Sub Category : Daclatasvir
Brand name : Daclahep
Generic Name : Daclatasvir
Company Name : Hetero
Tablets : 28 / Package : 3x28
Strength : 60 mg

  

Availability: In Stock

Medicine Overview of Daclahep Tablet


Uses of Daclahep Tablet


Daclahep 60mg is an anti-viral drug which is  useful for the treatment of chronic hepatitis C viral infection by preventing the multiplication of hepatitis C virus. Daclahep is included  to treatment of genotype III advanced hepatitis C virus in adults without cirrhosis

Generally Daclahep 60mg  tablets are not administrated alone, it may combined with other anti-viral medicines like Sofosbuvir, interferon and ribavirin

Side effects of Daclahep Tablet


Serious side effects of daclahep 60mg

Digestive problem: decreased appetitie

Cardiovascular: symptomatic bradycardia, heart block, cardiac aeehythnias

Liver problems: increased ALT and AST, rise in total bilirubin

Musculoskeletal: myalagia, athralgia, back pain

Genitourinary : UTI

Central nervous system: headache, dizziness,migraine

Mental disorder: insomnia, irritability, anxiety

Ocular: dry eye

Common side effects of daclahep 60mg 

Allergic reaction, breathing difficulty, swelling of peripheral organs

Combination daclahep with amiodarone causes very slow heartbeat, chest pain, dyspnae.

How to use Daclahep Tablet


The doctor prescribe daclahep 60mg based on age, past medical history and current status of diagnosis.

             When combination with Sofosbuvir the dose recommended is one tablet of 60mg taken once in a day by oral route with or without food. Duration of treatment – 12weeks

Modification of dose :  Reduce 30mg OD for strong CYP3A leads no  Dose reduction. Increase dose to 90mg OD with moderate CYP3A leads to contraindicated.

For genotype 1 or 4 : treatment with daclatasvir +ribavirin+ peg IFN for 12 weeks

For genotype 2 : treatment with daclatasvir + ribavirin for 12 weeks

For genotype 3: treatment with daclatasvir + ribavirin (without interferon) for 24 weeks.

OVERDOSAGE: Daclahep 60mg overdose has no particular antidote. Treatment will consist of supportive measures, involving monitoring of vitals and patient clinical status observation.

How to Daclahep Tablet works:


Daclahep 60mg is a direct acting antiviral drug which is used for the patient affected by hepatitis c virus infection. It will targets the Hepatitis C virus and blocks the numerous steps in reproduction process of HCV by the way it interfere with the virus particles from making copies themselves, and  helps the body to remove virus  from the blood.

  • Absorption: Poor absorption, peak plasma concentration is 2 hours post dose and bioavailability is 67%
  • Distribution: while multiple dosing, plasma protein binding is 99%, on dialysis it significantly decrease the plasma binding and vol of distribution is 47L
  • Metabolism: Daclatasvir is primarily metabolized through CYP3A4
  • Elimination: Daclatasvir excreted through feces of  (88%,53% unchanged) ; urine (6.6% primarily unchanged).
  • Terminal half life elimination is 12 – 15 hours

In Depth Information on Daclahep Tablet:


Expert Advice for Daclahep Tablets


  • Combination of  daclahep 60mg and amiodarone may cause bradycardia

  • Drugs should given with prescription only, without prescription drugs should not be issued.
  • Inform your healthcare providers that you are allergic to daclatasvir ,Sofosbuvir or  have any other allergies before using the medicine. It may composed of inactive ingredients, that can  be cause allergic problems or other reaction. Talk to your pharmacist for more details.
  • If you had any  kidney disease, liver disease other than hepatitis C, inform your consultant about past medical history before having daclatasvir or Sofosbuvir.

Special Warnings of Daclahep Tablets



Alcohol


There is no data available for Daclahep 60mg. Please consult your doctor

Pregnancy


Pregnancy category for Daclahep 60mg is not predicted, when oral dose the animal studies have failed to explain the signs of fetal harm. There are no controlled data in human pregnancy. This drug should use with combination of other antiviral drug. Use of ribavirin containing regimen is contraindicated in pregnant women and the male partner. For some authorities, this drug should avoid during pregnancy.

Lactation


Low amount of this drug  in breast milk as Daclahep 60mg is highly bound to maternal plasma protein, If the drug require for the feeding mother and it is not a reason for discontinue breastfeeding, If the drug using with ribavirin avoid breast feeding.

Driving


While taking Daclahep 60mg  you will feel dizziness, difficulty in concentrating and vision problem this may affect your driving. So avoid driving till you feeling well.



Kidney


Daclahep 60mg has no dosage adjustment recommended with renal dysfunction. Please consult with your doctor

Liver


Mild, moderate or severe liver dysfunction has no dose adjustment recommended in Daclahep 60mg . Please consult with your doctor



Missed Dosage


As soon as you remember take the missed dose. If time for next dose then skips the missed dose and follow the routine scheduled. Do not take more than one tablet per day. Please consult your doctor for further details.



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Daclahep

 
Category: --------------------Hepatitis Drugs
Sub Category:-------------------- Daclatasvir
Brand name:-------------------- Daclahep
Ingeridents(Generic Name) :-------------------- Daclatasvir
Package:-------------------- 28 /3x28
Strength :-------------------- 60 mg

GOOD QUALITY PRODUCTS


FREE SHIPPING FOR 12 WEEKS OF HEPATITIS DRUGS BY EMS

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