Category : Hepatitis Drugs
Sub Category : Sofosbuvir-Velpatasvir
Brand name : Velpaclear
Generic Name : Sofosbuvir + Velpatasvir
Company Name : Hetero
Tablets : 28 Tablets / Package : 3x28
Strength : 400mg + 100mg


Availability: In Stock

Medicine Overview of Velpaclear Tablet

Uses of Velpaclear Tablet

Velpaclear contain active ingredient of Sofosbuvir 400mg and Velpatasvir 100mg is  indicated for the treatment of  patients who are suffered with chronic hepatitis C viral infection associated genotype I, II, III, IV, V or VI infection without cirrhosis or with compensated cirrhosis.

Decompensated cirrhosis with use of ribavirin is used with Velpaclear.

Side effects of Velpaclear Tablet

  • The patient having sign of allergic reaction to velpaclear like difficulty, swelling of face, lip, tongue or throat.
  • Common side effects

Nausea and insomnia, to avoid the risk of insomnia and nausea, drug taken early in day time and with food

     Decrease red blood cell count. Routine check up required

  • More common: head pain & weakness

Less common: feeling sad, rash, dyspnea, lack of strength, concentration trouble, bradycardia, nasopharyngitis

How to use Velpaclear Tablet

  • In adult one tablet of velpaclear  containing dose of Sofosbuvir 400mg and Velpatasvir 100mg taken orally.
  • It can take it with or without food.
  • On a daily basis the particular medicine should be take at same time.
  •  Patient with non cirrhotic or with compensated cirrhosis used alone for 12 weeks duration.
  • Patients with decompensated cirrhosis used with combination of ribavirin for 12 weeks duration

Velpaclear for a period of 12 weeks at a stretch is used by the patient, it will bring amazing rate of constant virologic response for the patients who having the HCV infections of the genotypes 1, 2, 3, 4, 5 or 6.In treatment it plays a major role ,since this particular drug has the nucleotide polymerase inhibitor associated with it . it can be used either alone or  use it with ribavirin for the treatment..

If overdose occurs: Velpaclear overdose has no specific antidote available, If it occur patient should monitor for evidence of toxicity and provide supportive measure treatment  including vitals, clinical status observation of patient or seek to emergency medical department or call poison control helpline.

How to Velpaclear Tablet works:

Both drugs sofosbuvir 400mg and Velpatasvir 100mg is essential for blocking two proteins multiplication of hepatitis C virus.

 Sofosbuvir stops the action of an enzyme called "NS5B RNA-dependent RNA polymerase”and reduce amount of hepatitis C virus present in the body.

Velpatasvir binds a protein "NS5A" and blocks the virus multiplication spreading inside the body

ABSORPTION: oral administration of Velpaclear, the peak plasma concentration of Sofosbuvir approx 0.5-1 hour after the dose and Velpatasvir occurs 3 hrs after the dose. In healthy adult and infected adults , have plasma concentration and AUC of Velpatasvir are 42 and 37% lower.

Administration of food with moderate fat or high fat meal both drugs (Sofosbuvir/Velpatasvir) increases the exposure Sofosbuvir (60 or 305 fat) and Velpatasvir (34 or21%) respectively

DISTRIBUTION: Plasma protein binding is 61-65% for Sofosbuvir and >99.5% is Velpatasvir

METABOLISM: Sofosbuvir metabolized in liver by GS-461203 and desphosphorylation leads to formation of GS-331007.

Velpatasvir: Metabolized by CYP2B6,2C8 and 3A4.

ELIMINATION: Sofosbuvir major route is renal clearance via urine 80% and14% in feces and 2.5% in expired air.

Velepatasvir major route is biliary excretion and dose eliminated 94% in feces and 0.4% in urine and half life is Sofosbuvir 0.5hours, its GS-331007 is 25 hours and Velpatasvir is 15 hours.

In Depth Information on Velpaclear Tablet:

Expert Advice for Velpaclear Tablets

Before taking Velpaclear 400mg/100mg, care to be taken:

  • About prescription or non prescription, medication, vitamins, nutritional supplement you are taking or plan to take then inform your doctor due to drug interaction.

  • If planning to take antacid along with velpaclear then should give time interval of  4hours before or after the drug and incase of medication of indigestion, heartburnor ulcers (h2 blockers) then doctor should inform you take 12 hours before and after or same time of Velpaclear administrating.
  • Allgeric to any other medication or ingredients of Sofosbuvir /Velpatasvir or alone regimen. Tell  to your doctor
  • Inform your doctor about past and present history of disease (liver disease, kidney problem or on dialysis or HIV
  • If you are pregnant or planning for pregnancy or breast feeding. Inform your doctor pirorly.

Special Warnings of Velpaclear Tablets


Unknown  interaction between Velpaclear 400mg/ 100mg and alcohol. Please consult with doctor for further details.


Velpaclear combination with ribavirin regimen is contraindicated in pregnant women. In humans no sufficient data available to describe whether or not Velpaclear 400mg/100mg posses a risk unborn baby. Studies of animal reproduction, failed to reveal the effect of fetal harm.


It is unknown whether the components of Velpaclear 400mg/100mg and its metabolites are occur inside human breast milk, affect human milk production, or have effects on the breastfeeding infant.


On treatment with Velpaclear 400mg/100mg , without feeling well do not go for drive because when Velpaclear co administration with other medicine for treatment of hepatitis C, It may produce vertigo and blurred vision and also affect driving ability


Kidney problem with mild to moderate renal impairment have no dose adjustment required and patient with severe problem or ESRD require dose adjustments and use the Velpaclear 400mg/100mg with caution. Please  consult with doctor before using drug.


Velpaclear 400mg/100mg is safe to use with hepatic problem. No dose adjustment required for those patient. For further information consult with your doctor. But for some patients liver function test should be monitor on treatment with Velpaclear tablet.

Missed Dosage

As soon as you remember take the missed dose. If time for next dose then skips the missed dose and follow the routine scheduled. Do not take more than one tablet per day. Please consult your doctor for further details.

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Category: --------------------Hepatitis Drugs
Sub Category:-------------------- Sofosbuvir-Velpatasvir
Brand name:-------------------- Velpaclear
Ingeridents(Generic Name) :-------------------- Sofosbuvir + Velpatasvir
Package:-------------------- 28 Tablets/3x28
Strength :-------------------- 400mg + 100mg




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