Medicine Overview of Dacihep
DACIHEP Marketed by: Zydus Heptiza
Dacihep 60mg tablet is a trade name of daclatasvir and It is an antiviral drug which inhibits the hepatitis C virus in the body. One tablet of dacihep contain 60mg strength. In adult dacihep 60MG is used with combination of other medications (Sofosbuvir, ribavirin and interferon) based on type of virus and with or without cirrhosis patients.
Uses of Dacihep
Dacihep 60 mg is used with other antiviral agent for the treatment of chronic Hepatitis C virus ( viral infection of liver which will long last in the body). It will cause serious liver problem(cirrhosis, liver cancer).
Dacihep 60mg tablet Combination with Sofosbuvir reduce the bulk of Hepatitis virus in the body, in which it will help to fight against infection free immune system and clear the liver.
Side effects of Dacihep
Common side effects of dacihep 60mg
- Loss of hair
- Low RBC
- Loose stools
- Feeling sleepy in morning
- Head pain
- Itching/swelling(face, tongue,throat)
Serious side effects of dacihep 60mg
- Chest discomfort
- Loss of memory
- Unusual weight gain or loss
- Low heartbeats
How to use Dacihep
The doctor prescribe the Dacihep 60 mg based on age, past medical history and current status of diagnosis.
When combination with Sofosbuvir the dose recommended is one tablet of 60mg taken once in a day by oral route with or without food.
Duration of treatment – 12weeks
Modification of dose : Reduce 30mg OD for strong CYP3A leads no Dose reduction. Increase dose to 90mg OD with moderate CYP3A leads to contraindicated.
For genotype 1 or 4 : treatment with daclatasvir +ribavirin+ peg IFN for 12 weeks
For genotype 2 : treatment with daclatasvir + ribavirin for 12 weeks
For genotype 3: treatment with daclatasvir + ribavirin (without interferon) for 24 weeks.
OVERDOSAGE: Dacihep 60mg overdose has no particular antidote. Treatment will consist of supportive measures, involving monitoring of vitals and patient clinical status observation
How to Dacihep works
Hepatitis means person affected by hepatitis C virus and target the liver, thus became inflate. Due to longer stay of virus in the body leads to severe damage to the liver occurs. It is a CYP3A and p- glycoprotein. Daclatasvir attack the virus,and stops the process of multiplication and replication of the HCV. Here by drug will prevents the virus particle duplication by its own and removes the virus from the body.
Absorption: Poor absorption, peak plasma concentration is 2 hours post dose and bioavailability is 67%
Distribution: while multiple dosing, plasma protein binding is 99%, on dialysis it significantly decrease the plasma binding and vol of distribution is 47L
Metabolism: Daclatasvir is primarily metabolized through CYP3A4
Elimination: Daclatasvir excreted through feces of (88%,53% unchanged) ; urine (6.6% primarily unchanged).
Terminal half life elimination is 12 – 15 hours.
In Depth Information on Dacihep
Expert Advice for Dacihep
- Tell your healthcare providers that you are allergic to daclatasvir or have any other allergies before using the medicine. It may composed of inactive ingredients, that can be cause allergic problems or other reaction. Talk to your pharmacist for more details.
- Especially if you have kidney disease, liver disease other than hepatitis C, inform your consultant about past medical history before having daclatasvir.
Drugs should given with prescription only, without prescription drugs should not be issued.
Special Warnings of Dacihep
There is no data available for Dacihep 60mg. Please consult your doctor
Pregnancy category for dacihep 60mg is not predicted, when oral dose the animal studies have failed to explain the signs of fetal harm. There are no controlled data in human pregnancy. This drug should use with combination of other antiviral drug. Use of ribavirin containing regimen is contraindicated in pregnant women and the male partner. For some authorities, this drug should avoid during pregnancy.
Low amount of this drug in breast milk as DaciHep 60mg is highly bound to maternal plasma protein, If the drug require for the feeding mother and it is not a reason for discontinue breastfeeding, If the drug using with ribavirin avoid breast feeding
While taking Dacihep 60mg you will feel dizziness, difficulty in concentrating and vision problem this may affect your driving. So avoid driving till you feeling well.
Dacihep 60mg has no dosage adjustment recommended with renal dysfunction. Please consult with your doctor
Mild, moderate or severe liver dysfunction has no dose adjustment recommended by using dacihep 60mg. Please consult with your doctor.
As soon as you remember take the missed dose. If time for next dose then skips the missed dose and follow the routine scheduled. Do not take more than one tablet per day. Please consult your doctor for further details
Amazing Review by Millionpharma
Write Your Own Review
Category: --------------------Hepatitis Drugs
Sub Category:-------------------- Daclatasvir
Brand name:-------------------- Dacihep
Ingeridents(Generic Name) :-------------------- Daclatasvir
Package:-------------------- 28 Tablets/3x28
Strength :-------------------- 60 mg