Medicine Overview of Resof Total Tablet
Uses of Resof Total Tablet
In adult Resof Total 400mg/ 100mg is used to treat chronic Hepatitis C infection. Resof total fights against the infection and helps to improve immune system and Easy recover of liver problem. Resof total is indicated for the treatment of patients who are suffered with chronic hepatitis C viral infection associated genotype I, II, III, IV, V or VI infection without cirrhosis or with compensated cirrhosis. Resof total used with ribavirin decompensated cirrhosis
Side effects of Resof Total Tablet
Signs of allergy with Sofosbuvir and Velpatasvir seek to medical emergency.
Shortness of breathing
Low RBC-pale skin,fast heart rate
Head pain ; feeling tried ; insomnia
How to use Resof Total Tablet
Resof total has common dosage is 400mg, depends upon course ,response and difficulties against the drug dosage may slightily vary for the treatment.
Resof total usually given 12weeks or 24weeks (depends on genotype) along with other combination antiviral drugs to treat HCV
Resof total should administrated orally in same time every day and taken with or without food
Resof total mainly recommended for adult, In children safety and efficacy of the drug is not established.
According to the weight of the patient Dose of ribavirin:
≥75kg: 1200mg/day Bd
On the basis of haemoglobin and creatine clearance dosage of ribavirin is decreased.
If overdose occurs: Resof total overdose has no specific antidote available, If it occur patient should monitor for evidence of toxicity and provide supportive measure treatment including vitals, clinical status observation of patient or seek to emergency medical department or call poison control helpline
How to Resof Total Tablet works:
Sofosbuvir is a nucleotide polymerase inhibitor and includes in direct acting antiviral drug. Sofovir expose to have a high barrier to the development of resistance and inhibits the hep C NS5B protein. Hence inhibits RNA polymerase enzyme by the cellular worker which will performs the multiplication process, Hence it stops the replication of Hepatitis C virus and decrease the amount of Hep C virus in liver. Sofosbuvir also acts to reduce damage in liver and improves function in liver.
Velpatasvir’s is domine of NS5A inhibitors bind completely with RNA at this site. And also thought that NS5A inhibitors bind the target during its action in multiplication when the binding site is defined . Prevention of NS5A is also known to produce protein redistribution into lipid droplets. The role of NS5A in RNA reproduction is not yet clear
Absorption: Oral administration, peak plasma concentration of Sofosbuvir is 0.5-1 hour after the dose and Velpatasvir peak plasma concentration is 3 hours after the dose. Administration of food with moderate fat or high fat meal both drugs (Sofosbuvir/Velpatasvir) increases the exposure Sofosbuvir (60 or 305 fat) and Velpatasvir (34 or21%) respectively
Distribution: human plasma protein binding of Sofosbuvir is 61-65% and Velpatasvir is >99.5% .
Metabolism: Sofosbuvir metabolized in liver by by GS-461203 and desphosphorylation leads to formation of GS-331007.Velpatasvir: Metabolized by CYP2B6, 2C8 and 3A4.
Elimination: Sofosbuvir major route is renal clearance via urine 80% and14% in feces and 2.5% in expired air. Velepatasvir major route is biliary excretion and dose eliminated 94% in feces and 0.4% in urine.
Half life of Sofosbuvir is 0.5hours, its GS-331007 is 25 hours and Velpatasvir is 15 hours.
In Depth Information on Resof Total Tablet:
Expert Advice for Resof Total Tablets
- If you are taking the antacids, it is important for you to take them either four hours before or four hours after the Resof total should consume either four hours before or 4 hours after the drug
- Concomitant use with inducers of p-gp and potent of CYP will leads to risk of reducing therapeutic effect.
- When Resof total 400mg/100mg Co administered with Amiodarone and other HCV drug causes serious symptomatic bradycardia.
- Resof total 400mg/100mg with ribavirin causes serious affect to unborn baby, avoid pregnancy during treatment.
Special Warnings of Resof Total Tablets
Alcohol interaction with Resof total 400mg/100mg is unknown. Please consult with doctor for further details
In animal studies its effect shown is low and no adverse effect in foetus and in human begins studies are prusing hence its probably safe to use during pregnancy. kindly consult doctor before use
If the breast feeding mother need Resof total 400mb/100mg, no need of discontinue the breast feeding for this reason but some physician may suggest to stop during drug used with ribavirin. According to them use of drug is not recommended. Exretion into human milk is unknown and in animal milk is excreted.
On treatment with Resof total 400mg/100mg , without feeling well do not go for drive because when Resof total co administration with other medicine for treatment of hepatitis C, It may produce vertigo and blurred vision and also affect driving ability
Kidney problem with mild to moderate renal impairment have no dose adjustment required and patient with severe problem or ESRD require dose adjustments and use the Resof total 400mg/100mg with caution.please consult with doctor before using drug.
Resof total 400mg/100mg is safe to use with hepatic problem. No dose adjustment required for those patient. For further information consult with your doctor. But for some patients liver function test should be monitor on treatment with Resof total tablet.
As soon as you remember take the missed dose. If time for next dose then skips the missed dose and follow the routine scheduled. Do not take more than one tablet per day. Please consult your doctor for further details.
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Category: --------------------Hepatitis Drugs
Sub Category:-------------------- Sofosbuvir + Velpatasvir
Brand name:-------------------- Resof Total
Ingeridents(Generic Name) :-------------------- sofosbuvir and velpatasvir
Package:-------------------- 28 Tablets/3x28
Strength :-------------------- 400mg & 100mg