Category : Hepatitis Drugs
Sub Category : Sofosbuvir + Velpatasvir
Brand name : Velpanat
Generic Name : sofosbuvir and velpatasvir
Company Name : Hetero
Tablets : 28 Tablets / Package : 3x28
Strength : 400mg & 100mg


Availability: In Stock

Medicine Overview of Velpanat Tablet

Uses of Velpanat Tablet

Velpanat is a fixed dose combination of Sofosbuvir 400mg and Velpatasvir 100mg and used alone regimen or with ribavirin for the treatment of chronic hepatitis C virus infection (HCV i.e recent viral infection which cause liver damage). Both the drugs are antiviral medications in which Sofosbuvir and Velpatasvir combination works by blocking the virus which cause hepatitis C infection from spreading inside body.

Side effects of Velpanat Tablet

While taking Velpanat 400mg/100mg, If any of these side effects occur then check with your doctor.

Without known incident

  • Pain in chest
  • Large swelling in sensory and sex organ, hands leg feet
  • Vertigo
  • Blisters in skin
  • Slow heartbeat
  • Breathing trouble

More common

  • Headache
  • Weakness

Less common

  • Loss of confidence
  • Decreased appetite
  • Loss of pressure
  • Rash
  • Insomnia

How to use Velpanat Tablet

Velpanat is fixed combination which contains Sofosbuvir 400mg and Velpatasvir 100mg indicated for  chronic HCV infection and HCV genotype 1,2,3,4,5,& 6 infection.

Oral route of administration

1 tablets of Sofosbuvir 40mg / velpatasvir 100mg  once daily.

Take the tablet at same time every day.

If overdose occurs: Velpanat overdose has no specific antidote available, If it occur patient should monitor for evidence of toxicity and provide supportive measure treatment  including vitals, clinical status observation of patient or seek to emergency medical department or call poison control helpline.

How to Velpanat Tablet works:

Velpanat 400mg/100mg is a direct-acting antiviral agents against the hepatitis C virus.

Sofosbuvir 400mg is HCV NS5B RNA-dependent RNA polymerase inhibitors, which is enforced for viral poliferation. Sofosbuvir will form the pharmacologically active uridine analog triphosphate (GS-461203) by undergoing intracellular metabolism and it will integrated into HCV RNA by using NS5B polymerase and work as a chain terminator. Most  specifically it will reduce the amount of hepatitis virus inside the body.

Velpatasvir 100mg is a antiviral regimen which is an inhibitors of HCV NS5A protein and needed  for viral multiplication. Resistance collection in cell culture and cross-resistance studies express velpatasvir binds the NS5A as its mode of action.

Absorption: Oral administration, peak plasma concentration of Sofosbuvir is 0.5-1 hour after the dose and Velpatasvir peak plasma concentration is 3 hours after the dose

Administration of food with moderate fat or high fat meal both drugs (Sofosbuvir/Velpatasvir) increases the exposure Sofosbuvir (60 or 305 fat) and Velpatasvir (34 or21%) respectively

Distribution: human plasma protein binding of Sofosbuvir is 61-65% and Velpatasvir is >99.5% .

Metabolism: Sofosbuvir metabolized in liver by by GS-461203 and desphosphorylation leads to formation of GS-331007.Velpatasvir: Metabolized by CYP2B6, 2C8 and 3A4.

Elimination: Sofosbuvir major route is renal clearance via urine 80% and14% in feces and 2.5% in expired air. Velpatasvir major route is biliary excretion and dose eliminated 94% in feces and 0.4% in urine.

Half life of Sofosbuvir is 0.5hours, its GS-331007 is 25 hours and Velpatasvir is 15 hours.

In Depth Information on Velpanat Tablet:

Expert Advice for Velpanat Tablets

     Before taking Velpanat 400mg/100mg, care to be taken:

  • Allgeric to any other medication or ingredients of Sofosbuvir /Velpatasvir or alone regimen. Tell  to your doctor.
  • About prescription or non prescription, medication, vitamins, nutritional supplement you are taking or plan to take then inform your doctor due to drug interaction.

  • If planning to take antacid along with velpanat then should give time interval of  4hours before or after the drug and incase of medication of indigestion, heartburnor ulcers (h2 blockers) then doctor should inform you take 12 hours before and after or same time of Velpanat administrating.
  • Inform your doctor about past and present history of disease (liver disease, kidney problem or on dialysis or HIV
  • If you are pregnant or planning for pregnancy or breast feeding. Inform your doctor pirorly.

Special Warnings of Velpanat Tablets


Unknown  interaction between Velpanat 400mg/ 100mg and alcohol. Please consult with doctor for further details.


Velpanat combination with ribavirin regimen is contraindicated in pregnant women. In humans no sufficient data available to describe whether or not Velpanat 400mg/100mg posses a risk unborn baby. Studies of animal reproduction, failed to reveal the effect of fetal harm


It is unknown whether the components of Velpanat 400mg/100mg and its metabolites are occur inside human breast milk, affect human milk production, or have effects on the breastfeeding infant.


On treatment with Velpanat 400mg/100mg , without feeling well do not go for drive because when Velpanat co administration with other medicine for treatment of hepatitis C, It may produce vertigo and blurred vision and also affect driving ability


Kidney problem with mild to moderate renal impairment have no dose adjustment required and patient with severe problem or ESRD require dose adjustments and use the Velpanat400mg/100mg with caution. Please  consult with doctor before using drug


Velpanat 400mg/100mg is safe to use with hepatic problem. No dose adjustment required for those patient. For further information consult with your doctor. But for some patients liver function test should be monitor on treatment with Velpanat  tablet.

Missed Dosage

As soon as you remember take the missed dose. If time for next dose then skips the missed dose and follow the routine scheduled. Do not take more than one tablet per day. Please consult your doctor for further details

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Category: --------------------Hepatitis Drugs
Sub Category:-------------------- Sofosbuvir + Velpatasvir
Brand name:-------------------- Velpanat
Ingeridents(Generic Name) :-------------------- sofosbuvir and velpatasvir
Package:-------------------- 28 Tablets/3x28
Strength :-------------------- 400mg & 100mg




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