Medicine Overview of Hepbest
Hepbest tablet is a antiviral as well as antiretroviral drugs which prevents Hepatitis B virus from reproduction in body.
Hepbest tablet is indicated for the treatment of chronic hepatitis B virus infection and HIV infection in adult.
Hepbest tablet is manufractured by Mylan Pharmaceuticals Pvt.Ltd
Uses of Hepbest
Hepbest is a brand name of Tenofovir alafenamide. It is an antiretroviral drugs and involves in nucleotide reverse transcriptase inhibitor(NRTI). In adult is used for the treatment of Chronic HBV infection with compensated liver disease and HIV infection.
Side effects of Hepbest
Common effects: head pain ,cough and back pain
Incident not known:
- Loss of appetite
- Urine frequency is less
- general feeling of discomfort
- more thirst
- light-colored stools
- lumbar pain
- right upper abdominal or stomach pain and fullness
- swelling of the face, fingers, or lower legs
- troubled breathing
- unusual tiredness or weakness
How to use Hepbest
In adult, Hepbest is used for the treatment of chronic HBV infection
25mg administer orally once in a day with food.
In pediatric, safety and efficacy not established <18years of age
IF OVERDOSE OCCURS: Seek to emergency medical care or call poison control centre immediately. Give all correct information.
How to Hepbest works
Tenofovir alafenamide is belongs to class of antiviral drug against the hepatitis B virus.
Tenofovir alafenamide is a prodrug of tenofovir.
Tenofovir alafenamide is then converted to tenofovir disproxil Fumarate via loss of water primarily by carboxylesterase 1 (CES1) in primary hepatocytes. Tenofovir Intracellularily , finally phosphorylated by cellular kinases for the formation the pharmacologically active metabolite tenofovir diphosphate.It interfere with the Hepatitis B virus proliferation via fusing into viral DNA by the HBV reverse transcriptase, which causes in DNA chain-termination.
Tenofovir diphosphate is a mammalian DNA polymerases which is an weak inhibitors and involves in mitochondrial DNA polymerase γ and there is no possibilities of toxicity to mitochondria in cell culture.
Absorption: Hepbest is a phosphonamide prodrug of Tenofovir, peak plasma concentration is approx 0.5hrs after the dose.
Food effect: Hepbest with a high fat meal increase AUC compared with administration in fasted state.
Distribution: Plasma protein binding is 80%
Metabolism: Only minimal metabolized by CYP3A
Elimination: Excreted by kidneys , 32% of dose in feces and<1% excreted in urine. Half life is 0.5hrs
In Depth Information on Hepbest
Expert Advice for Hepbest
Risk of development of HIV-1 resistance patients connect with HBV and HIV disease: Individual treatment of Hepbest should not be used for treatment of HIV infection causes risk of producing of HIV-1 resistance.
Discontinuation of hepatitis B treatment: If patient discontinued of Hepbest drug it will lead to severe acute exacerbation of HBV infection.hence liver function should monitor after several month discontinue of drug.
Lactic acidosis with steatosis: Hepbest 25 mg co administration of antiretroviral agaents or alone use will cause severe hepatomegaly including fatalities and lactic acidosis.
Risk of renal impairment: while taking Hepbest along with renal impaired function or nephrotoxic agents will increase risk of developing renal related side effects.
Special Warnings of Hepbest
On treatment with Hepbest 25mg drinking alcoholic beverages is safe or not depends upon number of factors involves the patient receiving drugs. Alcohol may inhibits some action of hepatitis drugs work. So patient should discuss with doctor about any adverse reaction of drinking during treatment.
Category B : While Hepbest 25 mg during pregnancy ,no malformation, fetotoxicity or neonatal toxicity, Hepbest referred for only limited number of pregnant women. In animal reproduction studies have shown negative risk to the fetus and there no sufficient and well – tolerated studies in pregnant women. This drug harms the unborn baby.
During hepbest 25mg treatment, breast feeding is avoided for the safety of the newborn baby. This drugs may included in breast milk in high levels and probably harm the baby. Check with the doctor whether breast feeding should stop temporarily or permanently while treatment
If dizziness, sleepy, tried or low alertness on drive happens then do not drive until you feeling well.
Hepbest 25mg treatment of patients with mild moderate, severe renal impairment has no dose adjustment and the drug is not recommended in patients with end stage renal disease. Consult with your doctor for further details
Patient with decompensated hepatic impairment is not recommended with Hepbest treatment, because safety and efficacy is not been established. No adjustment is required. Consult with your doctor.
As soon as you remember take the missed dose. If time for next dose then skips the missed dose and follow the routine scheduled. Do not take more than one tablet per day. Please consult your doctor for changes in dose or new schedule for replace of missed dose.
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Category: --------------------Hepatitis Drugs
Sub Category:-------------------- Tenofovir Alafenamide
Brand name:-------------------- Hepbest
Ingeridents(Generic Name) :-------------------- tenofovir alafenamide
Package:-------------------- 30 TABLETS/1X30
Strength :-------------------- 25MG