Medicine Overview of Tafnat
Tafnat tablet is a antiviral as well as antiretroviral drugs which prevents Hepatitis B virus from reproduction in body.
Tafnat tablet is indicated for the treatment of chronic hepatitis B virus infection and HIV infection in adult.
Tafnat tablet is manufractured by Natco Pharma.Ltd.
Uses of Tafnat
Tafnat 25mg (Tenofovir Alafenamide) is an antiretroviral drug and may used with antiviral medication,which is indicated for the treatment of chronic hepatitis B virus infection and some case of HIV infected patients treatment
Side effects of Tafnat
Consult with doctor immediately, if any of severe side effects occurs on treatment with Tafnat 25mg
Common side effects:
Pain in black ; cough and headache
Side effects not known:
- Abdominal or stomach discomfort
- bloody urine dark urine
- lack of appetite
- decreased frequency of urine
- fast shallow breathing
- increased thirst
- light-colored stools
- cramping nausea and vomiting
- fullness sleepiness
- swelling of the face, fingers, or lower legs
- troubled breathing
- unusual tiredness or weakness
- weight gain
- yellow eyes and skin
How to use Tafnat
Before starting of treatment Tafnat 25mg, patient should screening for HIV-1 infection. Tafnat alone should not be given for patients with HIV infection.
In adult Tafnat is used for chronic HBV infection which the drug contains Tenofovir Alafenamide 25 mg single tablet taken oral route once in a day with food.
No dosage adjustment required for renal and hepatic impairment.
Overdose: If Tafnat overdose occurs, check the patient for probability of toxicity and provide supportive measures or seek to emergency medical department or call poison helpline immediately
How to Tafnat works
Tenofovir alafenamide is an antiviral drug against the hepatitis B virus and also used in some HIV infections
Tenofovir Alafenamide (Tafnat 25mg) is a inhibitor of Nucleotide reverse transcriptase that fight against viral infection . which act as an Phosphonamidate prodrug, then Tenofovir is hydrolized in vivo and then phosphorylated to the active metabolite to form Tenofovir diphosphate. Drug will prevents the reproduction of HIV virus in human cells and then stops the HIV virus from producing new viruses and a novel ester prodrug of the antiretroviral tenofovir, use to treat HIV infection and chronic hepatitis B.Tafnat 25mg cause fast chain termination and interferes with proviral DNA 27 transcription.
Absorption: Tenofovir alafenamide Peak plasma concentration is approx 0.5hrs after the dose. Food effect: Tenofovir alafenamide with a high fat meal increase AUC compared with administration in fasted state
Distribution: Plasma protein binding is 80%
Metabolism : Only minimal metabolized by CYP3A
Elimination : Excreted by kidneys, 32% of dose in feces and<1% excreted in urine. Half life is 0.5hrs.
In Depth Information on Tafnat
Expert Advice for Tafnat
Lactic acidosis with steatosis:Tafnat 25 mg co administration of antiretroviral agaents or alone use will cause severe hepatomegaly including fatalities and lactic acidosis
Risk of development of HIV-1 resistance patients connect with HBV and HIV disease: Individual treatment of Tafnat should not be used for treatment of HIV infection causes risk of producing of HIV-1 resistance.
Risk of renal impairment: While taking Tafnat 25mg along with renal impaired function or nephrotoxic agents will increase risk of developing renal related side effects.
Discontinuation of hepatitis B treatment: If patient discontinued of Tafnat 25mg drug it will lead to severe acute exacerbation of HBV infection.hence liver function should monitor after several month discontinue of drug.
Special Warnings of Tafnat
On treatment with Tafnat 25mg drinking alcoholic beverages is safe or not depends upon number of factors involves the patient receiving drugs. Alcohol may inhibits some action of hepatitis drugs work. So patient should discuss with doctor about any adverse reaction of drinking during treatment.
Category B : While Tafnat25 mg during pregnancy ,no malformation, fetotoxicity or neonatal toxicity, Tafnat referred for only limited number of pregnant women. In animal reproduction studies have shown negative risk to the fetus and there no sufficient and well – tolerated studies in pregnant women. This drug harms the unborn baby.
During Tafnat 25mg treatment, breast feeding is avoided for the safety of the newborn baby. This drugs may included in breast milk in high levels and probably harm the baby. Check with the doctor whether breast feeding should stop temporarily or permanently while treatment
If dizziness, sleepy, tried or low alertness on drive happens then do not drive until you feeling well
Tafnat25mg treatment of patients with mild moderate, severe renal impairment has no dose adjustment and the drug is not recommended in patients with end stage renal disease. Consult with your doctor for further details.
Patient with decompensated hepatic impairment is not recommended with Tafnat 25mg treatment, because safety and efficacy is not been established. No adjustment is required. Consult with your doctor
As soon as you remember take the missed dose. If time for next dose then skips the missed dose and follow the routine scheduled. Do not take more than one tablet per day. Please consult your doctor for changes in dose or new schedule for replace of missed dose.
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Category: --------------------Hepatitis Drugs
Sub Category:-------------------- Tenofovir Alafenamide
Brand name:-------------------- Tafnat
Ingeridents(Generic Name) :-------------------- tenofovir alafenamide
Package:-------------------- 30 TABLETS/1X30
Strength :-------------------- 25MG