Medicine Overview of Cronivir
Manufactured by Hetero drugs Ltd.
Cronivir is a type of classification of antiviral drug and indicated to use for the treatment of HBV in adults and children (>2yrs). It is not a cure for hepatitis but inhibits the virus from multiplying in body. Whether Cronivir is not known will prevent cirrhosis or liver cancer.
Uses of Cronivir
Cronivir 0.5mg in adult and children < 2yrs, and its mainly used for treatment of long lasting Hepatitis B infection. The infection caused by Hepatitis B virus in liver. This infection will damage the liver and cause liver failure or liver cancer. The reducing of hepatitis B virus quantity in body is carried out by Cronivir tablet. Cronivir, after liver transplantation of the replication of HBV is prevented. Cronivir is indicated for HIV the selected patient resistance to lamivudine and Emtricitabine, hence its not prescribed for both HIV-HBV patient without fully stopping Cronivir drug.
Side effects of Cronivir
Cronivir 0.5mg causes mild to moderate side effects : Weakness, Tiredness, Head pain, lethargy, Nausea & Vomiting, low heartbeat , Light Headedness, pain in stomach, Muscle ache, Cold Legs, weight loss , Yellow colour change in Skin And Urine, Lightish colour change in Bowel Movements, Dyspnea, Dizziness. Major Adverse reaction Involves Lactic Acidosis.
How to use Cronivir
Entecavir prescribed for chronic hepatitis C virus infection and dose is 0.5mg in compensated liver disease in adults and adolescents 16 years of age and older.
Cronivir given one tablet of 0.5mg once daily.
Cronivir 0.5mg administrated on an empty stomach for atleast 2hrs after a meal or before the next meal.
Pediatric dose :
2 to 15 years for therapy new patients.
10 to 11 kg: 0.15 mg orally once a day
>11 to 14 kg: 0.2 mg orally once a day
>14 to 17 kg: 0.25 mg orally once a day
>17 to 20 kg: 0.3 mg orally once a day
>20 to 23 kg: 0.35 mg orally once a day
> 23 to 26 kg: 0.4 mg orally once a day
> 26 to 30 kg: 0.45 mg orally once a day
> 30 kg: 0.5 mg orally once a day.
OVERDOSAGE: If patients had single entecavir doses of 40mg or double dose of 20mg/day till 14days has no evidence of increase or any adverse effect. If overdose occurs then provide immediately supportive and symptomatic measurements such as vitals signs of toxicity of medicine
How to Cronivir works
Entacavir is belongs to the classification of antiviral drug and an nucleoside analogue show action against hepatitis B virus polymerase is effectively phosphorylated to the active triphosphate form, which require an intracellular half life of 15 hours. Cronivir tablet combination with natural substances such as deoxyguanosine triphosphate functionally prevents all three activities of HBV reverse transcriptase:
- Base priming
- Ergonomic messenger RNA produce negative strand of reverse transcription
- Synthesis of positive strand of HBV DNA.
Cronivir 0.5mg reduces the quantity of hepatitis virus in the blood and decrease the multiply and infect new cells by these three activities.
Absorption: Cronivir has peak plasma concentration between 0.5 and 1.5 hours and bioavailability is 100% relative to the oral solution. Effect of food: while on empty stomach is more effective for tablet absorption compared to with food.
Distribution: binding to human plasma protein of Cronivir is 13 %
Metabolism: small amount of phase II metabolites (glucuronide and sulfate conjugates) were observed
Elimination: Cronivir is widely excreted by the kidney with urinary unchanged drug recovery ranging from 62% to 73%.
Terminal elimination half life of Cronivir 24 hours.
In Depth Information on Cronivir
Expert Advice for Cronivir
Cronivir 0.5mg co administration other drugs( lamivudine, adefovir, dipivoxil, or tenofovir) will result no drug interaction and affect the renal function, hence patient should be monitored regularily.
The patient who discontinue the anti hepatitis treatment (Cronivir) should check the hepatic function follow up closely then restart of anti viral drug may be warned.
Special Warnings of Cronivir
Alcohol interaction with Cronivir 0.5mg is not known. Please consult your doctor for any inconveniency
Pregnancy category C: Cronivir 0.5mg may not be safe to use during pregnancy. In studies of animal reproduction has shown adverse effects on the fetus, in human studies has no adequate and well controlled data but probable benefits may permit to use the drug in pregnant women against possible risks
While breastfeeding, taking into account of serious of the Cronivir 0.5mg drug to the mother an decision should be made to discontinue the drug or discontinue breastfeeding. Excreted into human milk is unknown and in animal milk its excreted.
Cronivir 0.5mg cause side effects of dizzy, sleepy, tried or reduce alertness. If this you feel then avoid driving until you feeling well.
Patient with kidney problem use the Cronivir 0.5mg with caution. Dosage adjustment is required in renal impairment. Please consult the doctor for further clarifications.
Patient with hepatic impairment using cronivir 0.5mg have no dosage adjustment is Necessary.
If you missed a dose take it as soon as possible, if time reach for next dose, then skip missed dose and continue regular schedule. Do not take extra or double dose. Please consult with doctor.
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Category: --------------------Hepatitis Drugs
Sub Category:-------------------- Entecavir
Brand name:-------------------- Cronivir
Ingeridents(Generic Name) :-------------------- entecavir
Package:-------------------- 30 TABLETS/1X30
Strength :-------------------- 0.5mg