Myezom-2mg


QUICK OVERVIEW

Category : Anti-Cancer Drugs
Sub Category : Bortezomib
Brand name : Myezom-2mg
Generic Name : Bortezomib
Company Name : Hetero
Tablets : 1 vial / Package : 1x1
Strength : 2mg

  

Availability: In Stock

Medicine Overview of Myezom-2mg Tablet


Uses of Myezom-2mg Tablet


Myezom 2mg injection is used to treat the multiple myeloma in patients

Myezom 2mg injection is also indicated for the patients suffering from mantle cell lymphoma, who has been used at least 1 before treatment.

Side effects of Myezom-2mg Tablet


Myezom 2mg causes some effects in patient, In such situation, you should seek to the doctor immediately.

  • Decreased platelets

  • Psychiatric disturbances

  • Nausea

  • Vomiting

  • Decreased appetite

  • Low RBC

  • Peripheral neuropathy

  • Neutrophils

  • Constipation

  • Low energy, fever

How to use Myezom-2mg Tablet


Adult dose for lymphoma

Previously without treating mantle cell lymphoma dose:

1.3 mg/m2 ( bolus IV injection) twice weekly

Myezom Co administration with, cyclophosphamide, doxorubicin, and oral prednisone, IV rituximab for two weeks  i.e days 1, 4, 8, and 11 followed by a ten day rest period (days 12 through 21).

Treatment for relapsed mantle cell lymphoma

Regular dose: 1.3 mg/m2 which is administrated bolus IV injection or subcutaneously (SC) two times in  weekly for two weeks i.e  days 1, 4, 8, and 11 followed by a ten day rest period (days 12 through 21).

Treatment continuing beyond 8 cycles  may be given one day in weekly for 4 weeks  i.e days 1, 8, 15, and 22, followed by a 13-day rest (days 23 through 35).

Adult dose for multiple myeloma:

Previously without treating multiple myeloma dose:

1.3 mg/m2 which is administrated as 3 to 5 bolus IV injection or SC combine with oral melphalan and oral prednisone for 9 to 6 weeks therapy cycles.

Myezom  in 1 cycles through 4 cycles  administrated  two times in  weekly i.e days 1, 4, 8,11,22,25,29 and 32  and in  5 cycles through 9 cycles is administrated once weekly i.e days 1,8,22 and 29)

Treatment for relapsed multiple myeloma:

Regular dose: 1.3 mg/m2 which is administrated bolus IV injection or subcutaneously (SC) two times in  weekly for two weeks i.e  days 1, 4, 8, and 11 followed by a ten day rest period (days 12 through 21).

Treatment continuing beyond 8 cycles  may be given one day in weekly for 4 weeks  i.e days 1, 8, 15, and 22, followed by a 13-day rest (days 23 through 35).

OVERDOSE: Myezom  2mg has no specific overdosage, In human when administrated more than two times then the prescribed dose the it will causes symptomatic hypotension and thrombocytopenia. If occurs patients should monitored and give appropriate supportive care

How to Myezom-2mg Tablet works:


Myezom  2mg injection used in mammalian cells is a reversible inhibitor of the chymotrypsin-like activity of the 26-S proteasome. It inhibits targeted proteolysis which  affects multiple signaling cascades responsible for normal homeostatic functions within the cell, leading to cell death.

Absorption: the peak plasma concentration after 1st dose is 57 and 112ng/mL, If administrated  two times a week, Cmax observed for 1mg/m2dose is 67 to 106ng/mL, for 1.3mg/m2 is 89 to 720ng/mL.

Distribution: human serum plasma concentration is >80%

Metabolism: Myezom 2mg injection metabolized mainly through cytochrome P450 isoenzymes CYP3A4, CYP2C19 & CYP1A2.

Elimination: the excretion pathways of Myezom 2mg injection have not been characterized. The terminal elimination of half life after the 1mg/m2 dose is 40hrs - 193hrs, after dose 1.3mg/m2 is 76hrs - 108hrs.


In Depth Information on Myezom-2mg Tablet:


Expert Advice for Myezom-2mg Tablets


  1. Inform the doctor if you are allergic to bortezomib, any other regimens, or any of the ingredients in bortezomib capsules.
  2. Take into the knowledge that bortezomib may reduce the  fertility in men and women. It not means that you or your partner cannot become pregnant. Inform doctor before if you are pregnant or plan to become pregnant. After become pregnant, you should use birth control while  treatment with bortezomib and for at least 2 weeks after your treatment, become pregnant during bortezomib therapy, call your doctor immediately. bortezomib may harm the fetus.
  3. Inform the doctor if you are breastfeeding or plan to breastfeed. Avoid breastfeed during bortezomib treatment.
  4.  If you had any surgery, like dental surgery, tell to your doctor before starting therapy.
  5.  Bortezomib may cause dizziness, lightheadedness, and fainting on getting up in a lying position.  Commonly, People who have fainted in the past, dehydrated, and taking medications which lower blood pressure. To avoid this problem, get up from bed slowly,  keep your feet  resting on the floor for a few minutes piror to  standing up.

Special Warnings of Myezom-2mg Tablets



Alcohol


Myezom 2mg injection interaction with alcohol is unknown. Please consult with the doctor

Pregnancy


Category D: while administrating Myezom 2mg injection in pregnant women, positive evidence on fetal risk depends on human studies but potential benefits by using the drug  may have common risk against fetus.

Lactation


Category D: while administrating Myezom 2mg injection in pregnant women, positive evidence on fetal risk depends on human studies but potential benefits by using the drug  may have common risk against fetus.

Driving


Myezom 2mg injection will affect the ability of driving due to its side effects like drowsy, dizzy, or lightheadedness or fainting, blurred vision. Avoid driving unless you feeling well.



Kidney


Myezom 2mg injection used with caution in patients with severe renal disease, dose adjustment is required and limited data is available on the tablets in mild, moderate kidney problem, no dose adjustment is necessary .Please consult doctor.

Liver


The patient with severe liver disease should Myezom 2mg injection with caution. Limited information of the drug in mild to moderate liver disease. dose adjustment is needed. Please consult with doctor,



Missed Dosage


If any doses missed by you, administer the dose as soon as possible you remember, If it is near to next dose then skip the missed dose and follow the regular schedule. Avoid taking 2 dose or extra dose at a time. If you not able to follow regular dose schedule, keep an alarm to remind your dose schedule. Please consult the doctor for any dose schedule changes or new schedule for equally missed dose



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Myezom-2mg

 
Category: --------------------Anti-Cancer Drugs
Sub Category:-------------------- Bortezomib
Brand name:-------------------- Myezom-2mg
Ingeridents(Generic Name) :-------------------- Bortezomib
Package:-------------------- 1 vial/1x1
Strength :-------------------- 2mg

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