Medicine Overview of Tykerb
Tykerb 250mg is a antineoplastic drugs which interfere with the growth and spreadness of cancer cells throughout the body. Tykerb is indicated for metastatic breast cancer and spread after use of other cancer medicines.
Uses of Tykerb
Tykerb 250mg is used with combination of capecitabine for the treatment of advanced breast cancer after the failure of other cancer medicine.Tykerb is also used with letrozole combination to treat postmenopausal women with hormone receptor positive metastatic breast cancer.
Side effects of Tykerb
Common side effect: Lumbar pain ; diarrhae; dry skin; nail of finger toe changes; headache; in digestion problem ; decreased appetite; mild hair loss or thinning; mouth ulcers; nausea; nosebleed; redness and tingling of the hands and feet; tiredness; difficult in sleeping; vomiting.
Serious side effect: . pain in stomach; severe trightness; difficult in breathing; unusual bruising or bleeding; unusual itching; yellowing of the eyes or skin;.pain in chest; dark urine; dizziness or light-headedness; fast or irregular heartbeat; pale stools; persistent loss of appetite; severe or persistent cough; severe or persistent diarrhea, nausea, vomiting and skin allergy like itching,rashes,swelling in mouth,face,lip or tongue.
How to use Tykerb
Tykerb dosing for HER2 positive metastatic breast cancer ( with xeloda) is 1250mg once daily for 1-21days continuously repeating.
Combination with femara is 1500mg orally once a day continuosly once daily every day.
Administrate Tykerb on an empty stomach(1hr before or 1hr after).
How to Tykerb works
Tykerb 250mg is a type of classification called kinase inhibitor. Lapatinib is a 4-anilinoquinazoline kinase inhibitor of the intracellular tyrosine kinase Speciality of both Epidermal Growth Factor Receptor (EGFR [ErbB1]) and of Human Epidermal Receptor Type 2 (HER2 [ErbB2]) receptors with a dissociation half-life of ≥300 minutes. Tykerb interferes with ErbB-forced tumor cell development in vitro and in various animal models.. The development of virus inhibits the effects of Tykerb were examined in trastuzumab-conditioned cell lines. Tykerb maintained specific activity against breast cancer cell lines selected for long-term growth in trastuzumab-containing intracellularly. Hormone receptor-positive breast cancer cells (with ER [Estrogen Receptor] and/or PgR [Progesterone Receptor]) that coexpress the HER2 bear to be protection against established endocrine therapies. Simultaneously hormone receptor-positive breast cancer cells that initially lack EGFR or HER2 unrecalled these receptor proteins as the tumor becomes resistant to endocrine therapy.
ABSORPTION: Absorption from GI tract is not completed and variable. After administration peak plasma concentration is approx 4hrs.bioavailability is 95%. While administrate with food will increase the systemic exposure.
DISTRIBUTION: Plasma protein binding is 99%
METABOLISM: Evertor Metabolized mainly by CYP3A4 and CYP3A5.
ELIMINATION: Excreted dose through feces more than 14% and <2% of the dose via urine. Eliminated half life is 24hrs.
In Depth Information on Tykerb
Expert Advice for Tykerb
Tykerb 250mg should avoided If you are allergic to lapatinib
Piror for the treatment of Tykerb, should consult doctor whether it’s safe to use or not:as follows: hepatic problem, cardio disease, an electrolytic imbalance.
Tykerb 250mg should not prefer during pregnancy because it harm the unborn baby or cause birth defects.
Do not breast feeding during Tykerb treatment, it is not known whether Lapatinib passes into breast milk.
Special Warnings of Tykerb
Alcohol interaction with Tykerb 250mg is unknown. Please consult with your doctor
Tykerb 250mg should be used, if drug benefit confirm the specific risk of fetus. There is no adequate and well tolerated studies of Tykerb in pregnant women. Tykerb 250mg is unknown effect on human pregnancy. Do not become pregnant while receiving treatment withTykerb.
During breastfeeding, no data available for Tykerb 250mg. Since 99% binding to plasma proteins the drug amount is low in breast milk.hence increase in risk of infants when the drug given with the combination of capecitabine.
Tykerb 250mg will affect the ability of driving due to its side effects. Avoid driving unless you feeling well.
Tykerb 250mg used with caution in patients with severe renal disease, dose adjustment is required and limited data is available on the tablets in mild, moderate kidney problem. Please consult doctor.
The patient with liver disease should use this drug with caution. Limited information of the drug in severe liver disease. Please consult with doctor.
If you missed a dose take it as soon as possible, if time reach for next dose, then skip missed dose and continue regular schedule. Do not take extra or 2 dose at a time. Please consult with doctor.
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Category: --------------------Anti-Cancer Drugs
Sub Category:-------------------- Lapatinib
Brand name:-------------------- Tykerb
Ingeridents(Generic Name) :-------------------- Lapatinib
Package:-------------------- 30 TABLETS/1X30
Strength :-------------------- 250mg