Medicine Overview of Gefinat Tablet
Uses of Gefinat Tablet
Geftinat 250mg is an anticancer drug which is indicated for the treatment of metastatic non-small cell lung cancer after failure of both platinum and taxane based chemotherapies.
Side effects of Gefinat Tablet
Common side effects in Geftinat 250mg (occurring in greater than 30%):
Loose stools; skin reaction
Less common in Geftinat 250mg (occurring in about 10-29%):
- Poor appetite
- Eye irritation
How to use Gefinat Tablet
Geftinat 250mgis a form of tablet which taken by mouth. It is administrated with or without food once a day.
Recommeded dose of adult is 250mg.Take gefitinat at same time every day.
Take Geftinat 250mgexactly as directed. Avoid taking more or less or consume based on doctor’s advice.
If patient is not able to swallow the tablets, tablet may dissolve them in water. Take one tablet in 120 to 240 ml of plain, noncarbonated drinking water. 15 minutes require until the tablet is dissolved and use spoon to stir it.
Drink the mixture immediately. Rinse the glass with another 4 to 8 ounces of water and drink the rinse water completely to be sure that you swallow all of the drug.
Doctor may delay or permanently stop the treatment if you feel certain side effects. Inform your doctor when you feel difference after taking medication.
OVERDOSAGE: Geftinat has no specific treatment for the overdose.an increase of dose frequency and severity of some adverse reaction was observed like diarrhea and skin rash.
How to Gefinat Tablet works:
EGFR is a kind of protein found on the surface of cells in your body. Mutated EGFR plays a part in cancer growth by sending out signals that make the cells grow and divide.
But Geftinat 250mg may make a difference for you.attaches itself to certain abnormal types of the EGFR protein on your lung cancer cells. By doing so, it has been shown to slow down the growth of these cells and may help reduce the size of your tumors.
ABSORPTION: slow absorbed from GI tract, the bioavailability shows of approx 60% and peak plasma concentration time is 3-7hr.
DISTRIBUTION: volume of distribution in Geftinat is 1400L and plasma bounding is approx 90%.
METABOLISM: Geftinat 250mgmetabolized by hepatic via CYP3A4 and CYP2D6. It has major metabolites is o-desmethylgeftinib.
ELIMINATION: Geftinat 250mg eliminated through faeces (86%) and urine (<4%) and terminal half life is 41-48 hr.
In Depth Information on Gefinat Tablet:
Expert Advice for Gefinat Tablets
If you are allergic to Geftinat 250mg, avoid using the medicine.
To known about gefitinib is safe for you, inform the doctor if you have:
- hepatocellular disease
- Renal disease;
- Problems in visions.
- Dyspnea , lung disease other than lung cancer or
- Under treatment of blood thinner (warfarin, coumadin, Jantoven)
Avoid use of Geftinat 250mg if you are pregnant. It will harm the baby unborn, while using Geftinat 250mguse correct birth control to prevent pregnancy and for at least 2 weeks after your treatment ends. Geftinat 250mg may affect the ability to have children in women. Inform your doctor if you planning to pregnant.
It is unknown whether Geftinat 250mg passes into breast milk , avoid breast-feed while on gefitinib treatment.
Special Warnings of Gefinat Tablets
Alcohol interaction with Geftinat 250mg is unknown. Please consult with the doctor.
Category D: Geftinat 250mg show human fetal risk, but the use in pregnant women may be occur even with the risk . It is ineffective while the drug needed for life threatening situation.
In animal studies show that the drug and metabolite is present in milk of lactating rats. Hence while on treatment discontinue the breast feeding
Avoid driving unless you feeling well, while treatment with Geftinat 250mg you will feel dizzy, weekness and It affects the ability to drive.
Geftinat 250mg tablet should be used with caution in severe kidney problem patients. Ose adjustment is need. Please consult with the doctor
Geftinat 250mg is safe to use in patients with liver disease, limited data available. Dose adjustment may not be needed. Please consult with the doctor.
If you missed a dose take it as soon as possible, if time reach for next dose, then skip missed dose and continue regular schedule. Do not take extra or 2 dose at a time. Please consult with doctor.
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Category: --------------------Anti-Cancer Drugs
Sub Category:-------------------- Gefitinib
Brand name:-------------------- Gefinat
Ingeridents(Generic Name) :-------------------- Geftinib
Package:-------------------- 30 TABLETS/1X30
Strength :-------------------- 250mg