Medicine Overview of Bdenza
Bdenza 40mg is a type of classification of anti- androgen.
Bdenza 40mg medicine is a hormone treatment and effective. It contain Enzalutamide 40mg as active ingredient.
Bdenza 40mg should administrated according to doctor’s instructions and mainly prescription based drug.
Uses of Bdenza
Bdenza 40mg is clinically effective and indicated in the treatment of anti tumor activity of MDV3100 in a phase I/II study of castration resistant prostate cancer.
Side effects of Bdenza
Bdenza 40mg will causes some side effects.
COMMON SIDE EFFECTS: Body pain; dry throat; dizziness; sleeping trouble; cold symptoms such as stuffy nose; sore throat; Ear congestion; athralagia
SERIOUS SIDE EFFECTS: Epilepsy, fast heartbeat, breathing difficulty, chest discomfort, unusual weigth gain or loss.
How to use Bdenza
In adult usual dose is 160mg orally
Administrated once in a day has four tablet of 40mg capsule with or without food at same time every day.
Taken as a capsule by mouth, swallow the capsule whole
Do not crush or chew or dissolve capsule.
OVERDOSE OF BDENZA: If overdose occur, will cause seizure. Seek emergency medical attention or call poison helpline.
How to Bdenza works
Bdenza 40mg is an anti-androgen drug and it prevents androgen receptor inhibitor that acts on different stages in the androgen receptor communicating pathway.
Bdenza 40mg has been shown to competitively interfere with androgen linking to androgen receptors and prevents androgen receptor nuclear translocation and interaction with DNA.
A major metabolite, N‑desmethyl enzalutamide, exhibited similar in vitro activity to Bdenza.
Bdenza 40mg reduce proliferation and induced cell death of prostate cancer cells inside the body, and lowers tumor volume in a mouse prostate cancer engrafts model.
ABSORPTION: Bioavailabilty of Bdenza in human is unknown and in rate is 89.7%. peak plasma concentration is 1 hour (range 0.5 to 3 hours).
DISTRIBUTION: Plasma protein binding is 97 to 98% and metabolite N-desmethylenzalutamide
METABOLISM: The drug is metabolite in the liver by CYP2C8 and CYP3A4.
ELIMINATION: Excreted via urine 71.0%, bile in 13.6% and feces in 0.39% Half life is 5.8 days, with range of 2.8 to 10.2 days.
In Depth Information on Bdenza
Expert Advice for Bdenza
- Another medications which involves in prescription, over-the-counter, vitamins, herbal remedies, etc.and avoid Aspirin, or products related to aspirin your consultants permits this specifically. Inform your doctor before use of Bdenza 40mg
- While administrating Bdenza avoid any kind of immunization or vaccination until doctor’s approval
- Inform your Consltants if you are pregnant or planning to pregnant before starting the treatment.
- Due to severe adverse reactions in the new born baby, breast-feeding is not recommended.
Special Warnings of Bdenza
Alcohol interaction with Bdenza 40mg is unknown. Please consult with doctor.
In animal reproduction studies, there is a adverse effect for fetal, hence no human data on the use of Bdenza 40mg in pregnancy. Bdenza is contraindicated in women during pregnancy and cause fetal death and potential loss of pregnancy
Bdenza 40mg is not recommended to use in females. There is no information available in presence of Bdenza in human milk. The effects in the nursing infants are unknown.
While taking the Bdenza 40 mg dizziness occurs, It will affect the ability of driving. Avoid driving unless you feeling well.
When patients with mild ,moderate kidney disease no adjustment recommended in Bdenza 40mg. Patients with severe kidney problem or ESRD use with caution is recommended.
Bdenza 40mg has no dosage adjustment is necessary in mild or severe renal impairment. Caution recommended in moderate liver disease in patients.
If you missed a dose take it as soon as possible, if time reach for next dose, then skip missed dose and continue regular schedule. Do not take extra or 2 dose at a time.
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Category: --------------------Anti-Cancer Drugs
Sub Category:-------------------- Enzalutamide
Brand name:-------------------- Bdenza
Ingeridents(Generic Name) :-------------------- Enzalutamide
Package:-------------------- 112 tablets/4X28
Strength :-------------------- 40mg