Daruvir


QUICK OVERVIEW

Generic Name : Darunavir
Category : HIV Drugs
Company Name : Cipla Ltd
Dosage Form: 60 tablets
Strength : 600mg

  

Availability: In Stock

Medicine Overview of Daruvir Tablet


Uses of Daruvir Tablet


In adult daruvir is used with  combination  of cobicistate or ritonavir or other antiretroviral  for the treatment of HIV-1 infection.

In pediatric patients, Daruvir with Ritonavir combination is used for the treatment of HIV-1 infection.

Side effects of Daruvir Tablet


Signs of allergic reaction like Hives, Dyspnae, Swelling  of (face,lips, throat,tongue); Severe hepatomegaly with steatosis; Chest discomfort; Wheezing; Cold sore; increased heart rate; Lumbar pain

Common effects: Mild nausea,stomach ache, insomnia, itching and rashes,Change in body shape (fat).

How to use Daruvir Tablet


        In oral administration prescribed dose 600mg (2 dose of 300mg) taken twice daily (BD) with food.

 In adult patients

Treatment for no daruvir resistance associate substitutions  is 800mg daruvir OD with ritonavir OD with food.

               Treatment for at least one daruvir resistance associated  substitution is 600mg  daruvir with ritonavir 100mg BD with food.

OVERDOSAGE: Daruvir 600mg has no specific antidote for  overdose and treatment provide of general supportive measures involves monitoring of signs and patients clinical status observation.

How to Daruvir Tablet works:


Daruvir is an human immunodeficiency virus (HIV)-1 protease inhibitors. It especially prevent the separation of HIV-1 encoded Gag-Pol polyproteins in infected cells, therefore daruvir  will prevent the formation of mature virus molecule.

ABSORPTION:  Daruvir with co-administration with ritonavir 100mg in oral administration willproduce  Tmax( peak plasma concentration)of approx 2.5-4 hrs and bioavailabilty is 37% and 82% of Daruvir 600mg and ritonavir 100mg.

While administered with food , the Cmax and AUC is 40% similar to fasted state. So Daruvir is recommended with food is efficient.

DISTRIBUTION: Daruvir firstly  targets plasma α 1- acid glycoprotein(AAG),therefore plasma protein bound is 95%.

METABOLISM: Daruvir basically undergo oxidative metabolism by CYP3A.

ELIMINATION: After single dose or co administration with ritonavir will excreted approx 79.5%  in feces and 13.9% in urine. Constant Daruvir will eliminate approx 41.2% in feces and 7.7% in urine.

 The end excretion half life is 15hrs.


In Depth Information on Daruvir Tablet:


Expert Advice for Daruvir Tablets


Allergy to darunavir, ritonavir, or any other drug. Discuss with doctor about allergic to any drugs pirorily. This includes about rash; hives; itching; Dyspnea; wheezing; cough; swelling of (face, lips, tongue, or throat); or any other signs.

Patient has a sulfa allergy, talk with your doctor. If you are not taking  ritonavir.

If you had kidney or liver disease and taking colchicines then inform your doctor, he may stop the daruvir drug.

While patients on didanosine treatment, take the tablet 2 hours after or 1 hours before the darunavir tablet

Inform your doctor that you are pregnant or plan for pregnancy or breast feeding, while you infected with HIV or taking daruvir tablet avoid breast feed.


Special Warnings of Daruvir Tablets



Alcohol


Alcohol interaction with daruvir 600mg is unknown. Please consul the doctor.

Pregnancy


Category C:  In animal studies described that in reproduction there is an adverse reaction on fetus and there are no sufficient and well described  studies in human but the drug usage in pregnant women distribute potential risk for fetus.

Lactation


Daruvir 600mg is preferably unsafe to use during breastfeeding. Please consult with doctor

Driving


Due to the side effects of the drug daruvir, caution is advice while driving.



Kidney


While taking Daruvir 600mg and renal impairment has no interaction. No dosage adjustment is necessary. Please consult with doctor.

Liver


No dose adjustment is required for the patients with either mild or moderate liver disease. Limited  data  available  for the patient with severe hepatic disease



Missed Dosage


If you forget to take a dose , wait and take your next dose at the normal time otherwise take it as soon as you can and take your next dose at the normal time. Avoid taking extra medicine to make up for a missed dose.



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Daruvir

 
Brand Name : <--------------------> Daruvir
Category : <--------------------> HIV Drugs
Sub Category :<--------------------> Darunavir
Company Name :<--------------------> Cipla Ltd
Ingeridents(Generic Name) :<--------------------> Darunavir
Dosage Form :<--------------------> 60 tablets
Package :<--------------------> 1X60
Strength :<--------------------> 600mg

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