Instgra


QUICK OVERVIEW

Generic Name : Dolutegravir
Category : HIV Drugs
Company Name : Emcure pharmaceuticals Ltd
Dosage Form: 30 TABLETS
Strength : 50mg

  

Availability: In Stock

Medicine Overview of Instgra Tablet


Uses of Instgra Tablet


Instgra 50mg is a human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor (INSTI) used in combination with other antiretroviral agents to treat  the HIV-1 infection in adults and pediatric patients  having at least 30 kg weighing. And In adults indicated with  combination of rilpivirine for the treatment of HIV-1 infection to change the current antiviral medicine in those who are virologically withhold HIV-1 RNA  on a stable antiviral medicine for at least 6 months without any history of treatment failure or known changes associated with resistance to either antiretroviral agent.

Side effects of Instgra Tablet


Consult with your doctor if you feel any following side effects:

Less common side effects of instgra 50mg tablets

Bloody urine

Peeling skin

Black, tarry stools

Low frequency of urine

Decrease appetite

Muscle pain

Swollen glands

Swelling of the face, fingers, feet or lower legs

Troubled breathing

Unusual bruising

Yellow eyes and skin

Incidence not known

Clay colored stools

Decreased appetite

Stomach tenderness.

How to use Instgra Tablet


In adults dose

Instgra recommended for New patients or experienced virologically suppressed patients  changing  to this drug combined with ripivirne given 50mg orally once a day

When coadministered with certain UGT1A or CYP450 inducers administred 50mg orally twice a day.

INSTI- experienced patients with certain INSTI- correlated resistance substitutions administer 50mg orally twice a day

In pediatric dose

Patients weighing 30 to < 40mg administer 35mg orally once a day

Patients weighing atleast 40kg administer 50mg orally once a day.

Instgra can be taken with or without food but probably taken with food to enhance exposure.

How to Instgra Tablet works:


Instgra 50mg prevents the human immunodeficiency virus integrated by joining  to the integrase active site and stop the strand transfer step of retroviral Deoxyribonucleic acid (DNA) integration that is specific for the HIV proliferation cycle.

Absorption: rapidly absorped from GI Tract and peak plasma concentration is 2 to3 hours post dose

Distribution: Dolutegravir plasma protein binding is >99%

Metabolism : primarily metabolized via glucuronidation through UGT1A1 with a minor CYP3A component.

Elimination : reanal eliminated, 53% through feaces and 32% total oral dose  excreted in urine.

The terminal half life is -14 hours.


In Depth Information on Instgra Tablet:


Expert Advice for Instgra Tablets


Consult your doctor before these symptoms or conditions:

  • Allergic to dolutegavir, any other medications or any consitituent in Instgra rtablets.
  • Treatment on dofetilide, probably doctor stop Instgra
  • Using other prescription or non prescription , vitamins, herbal supplements using or decided to use
  • Taking antacids or laxatives which contain aluminium, magnesium, or calcium or buffered medications give the drugs 2 hours after or 6 hours after piror to take dolutegravir.
  • If you or had before kidney or liver disease
  • If you are pregnant or plan to pregnancy or breast feeding

Special Warnings of Instgra Tablets



Alcohol


Instgra 50mg Interaction with alcohol is unknown. Please consult the doctor.

Pregnancy


The use of Instgra 50mg in pregnant women there are limited data available. Instgra effects on human pregnancy is unknown. The drug can be used during pregnancy If expected benefit justify the specific risk to the fetus.

Lactation


Instgra 50mg is excreted into human milk is unknown. It is recommended breastfed mother with HIV infection avoid breastfeed to their infants at any circumstances to get ride of transmission of infection.

Driving


During treatment with Instgra 50mg , dizziness is reported has side effects. Avoid driving until u feeling well to drive.



Kidney


No dosage adjustment required for patients with mild ,moderate,or severe renal impairment using instgra 50mg. Please consult with the doctor.

Liver


No dosage adjustment required for patients with mild ,moderate and no data available in severe hepatic impairment using instgra 50mg. Please consult with the doctor.



Missed Dosage


As soon as you remember take the missed dose. If time for next dose then skips the missed dose and follow the routine scheduled. Do not take more than one tablet per day. Please consult your doctor for changes in dose or new schedule for replace of missed dose.



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Instgra

 
Brand Name : <--------------------> Instgra
Category : <--------------------> HIV Drugs
Sub Category :<--------------------> Dolutegravir
Company Name :<--------------------> Emcure pharmaceuticals Ltd
Ingeridents(Generic Name) :<--------------------> Dolutegravir
Dosage Form :<--------------------> 30 TABLETS
Package :<--------------------> 1X30
Strength :<--------------------> 50mg

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