Medicine Overview of Naivex Tablet
Uses of Naivex Tablet
Naivex 50mg is a human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor (INSTI) used in combination with other antiretroviral agents to treat the HIV-1 infection in adults and pediatric patients having at least 30 kg weighing. And In adults indicated with combination of rilpivirine for the treatment of HIV-1 infection to change the current antiviral medicine in those who are virologically withhold HIV-1 RNA on a stable antiviral medicine for at least 6 months without any history of treatment failure or known changes associated with resistance to either antiretroviral agent.
Side effects of Naivex Tablet
Consult with your doctor if you feel any following side effects:
Less common side effects:
Black, tarry stools
Low frequency of urine
Swelling of the face, fingers, feet or lower legs
Yellow eyes and skin
Incidence not known
Clay colored stools
How to use Naivex Tablet
In adults dose
New patients or experienced virologically suppressed patients changing to this drug combined with ripivirne given 50mg orally once a day
When coadministered with certain UGT1A or CYP450 inducers administred 50mg orally twice a day.
INSTI- experienced patients with certain INSTI- correlated resistance substitutions administer 50mg orally twice a day
In pediatric dose
Patients weighing 30 to < 40mg administer 35mg orally once a day
Patients weighing atleast 40kg administer 50mg orally once a day.
Naivex can be taken with or without food but probably taken with food to enhance exposure.
OVERDOSAGE: Naivex has no specific therapy for an overdose. If occurs then provide the patient with supportively with appropriate monitoring as necessary.
How to Naivex Tablet works:
Naivex prevented the human immunodeficiency virus integrated by joining to the integrase active site and stop the strand transfer step of retroviral Deoxyribonucleic acid (DNA) integration that is specific for the HIV proliferation cycle.
Absorption: rapidly absorped from GI Tract and peak plasma concentration is 2 to3 hours post dose
Distribution: Dolutegravir plasma protein binding is >99%
Metabolism : Primarily metabolized via glucuronidation through UGT1A1 with a minor CYP3A component.
Elimination : Renal eliminated, 53% through feaces and 32% total oral dose excreted in urine.
The terminal half life is -14 hours.
In Depth Information on Naivex Tablet:
Expert Advice for Naivex Tablets
Consult your doctor before these symptoms or conditions:
- Allergic to dolutegavir, any other medications or any consitituent in dolutegavir tablets.
- Treatment on dofetilide, probably doctor stop Naivex 50mg
- Using other prescription or non prescription , vitamins, herbal supplements using or decided to use
- Taking antacids or laxatives which contain aluminium, magnesium, or calcium or buffered medications give the drugs 2 hours after or 6 hours after piror to take dolutegravir.
- If you or had before kidney or liver disease.
- If you are pregnant or plan to pregnancy or breast feeding.
Special Warnings of Naivex Tablets
Naivex 50mg Interaction with alcohol is unknown. Please consult the doctor.
The use of Naivex 50mg in pregnant women there are limited data available. Naivex effects on human pregnancy is unknown. The drug can be used during pregnancy If expected benefit justify the specific risk to the fetus.
Naivex 50mg is excreted into human milk is unknown. It is recommended breastfed mother with HIV infection avoid breastfeed to their infants at any circumstances to get ride of transmission of infection.
During treatment with Naivex 50mg , dizziness is reported has side effects. Avoid driving until u feeling well to drive.
No dosage adjustment required for patients with mild ,moderate,or severe renal impairment. Please consult with the doctor
No dosage adjustment required for patients with mild ,moderate and no data available in severe hepatic impairment. Please consult with the doctor
As soon as you remember take the missed dose. If time for next dose then skips the missed dose and follow the routine scheduled. Do not take more than one tablet per day. Please consult your doctor for changes in dose or new schedule for replace of missed dose.
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Brand Name : <--------------------> Naivex
Category : <--------------------> HIV Drugs
Sub Category :<--------------------> Dolutegravir
Company Name :<--------------------> Hetero healthcare Ltd
Ingeridents(Generic Name) :<--------------------> Dolutegravir
Dosage Form :<--------------------> 30 TABLETS
Package :<--------------------> 1X30
Strength :<--------------------> 50mg