Generic Name : Lopinavir And Ritonavir
Category : HIV Drugs
Company Name : Cipla Ltd
Dosage Form: 60 tablets
Strength : 200mg+50mg


Availability: In Stock

Medicine Overview of Lopimune Tablet

Uses of Lopimune Tablet

Lopimune 200mg/50mg  is mainly used in adult by combination with antiretroviral drugs for the treatment of HIV- 1 infection

Side effects of Lopimune Tablet

  • GI effects: abdominal pain, nausea, vomiting, diarrhea, anorexia
  • Common side effects: asthenia, taste disorder, headache, numbness or tingling around the mouth or extremities, anxiety, insomnia, fever, dizziness, malaise, hyperaesthesia, pharyngitis, rash, pruritus, sweating, vasodilatation, wt loss,
  • Allergic reactions : urticaria, bronchospasm, angioedema, mild skin eruptions, immune reconstitution syndrome, lipodystrophy, osteonecrosis,
  • Metabolic abnormalities: hypertriglyceridaemia, hypercholesterolaemia, insulin resistance, hyperglycaemia, hyperlactataemia.
  • Reduced levels of Hb, K, free and total thyroxine; increased eosinophil, liver enzymes, amylase and uric acid; reduced or increased WBC and neutrophil counts.
  • Major side effects: Pancreatitis, hepatic dysfunction, Stevens-Johnson syndrome. Rarely, anaphyla.

How to use Lopimune Tablet

Adult patients:

Lopimune recommended dose is 400/100mg ( given to patients as two 200/50mg tablets) twice daily (BD)

In patients with < 3 lopinavir resistance associated substitions dose prescribed as 800/200mg (given as 4 tablets of 200/50mg) once daily.

In combination with anticonvulsant drugs, lopimune is not recommended once daily.

Lopimune concomitant use with Efavirenz, nevirapine or nelfinavir once daily is not recommended and dose increased for all patients is 500/125mg of lopimune tablets in combination with Efavirenz, nevirapine or nelfinavir is given twice daily as two tablet of 200/50mg and one tablet of 100/25mg.

Pediatric patients:

In patients < 18 years of age the tablet lopimune should not administrated once daily.

The lopimune dose is calculated based on BSA or Weight.

6 months to 18 years

15 -25 kg or BSA < 0.9 m2 – lopinavir 200mg & Ritonavir 50mg twice a day orally

>25 – 35 kg or BSA 0.9 to < 1.4 m2 – lopinavir 300mg & Ritonavir 75 mg twice daily orally.

> 35kg or BSA at least 1.4m2 – lopinavir 400mg & Ritonavir 100mg twice daily orally.

Concomitant Efavirenz, nelfinavir or nevirapine

15 -20kg or BSA 0.6 to < 0.8m2 – Lopinavir 200mg & Ritonavir 50mg orally.

>20 – 30kg or BSA 0.8 <1.2m2 – lopinavir 300mg – Ritonavir 75mg orally twice a day.

> 30 – 45 kg or BSA 1.2 to <1.7m2 – lopinavir 400mg – Ritonavir 100mg orally twice a day

> 45kg or BSA at least 1.7m2: - Lopinavir 500mg & Ritonavir 125mg twice a day orally.

How to Lopimune Tablet works:

             Lopimune  is a reversible HIV protease inhibitor  which includes with  the  specific formation of proteins and enzymes. Lopimune  inhibits the  virus infection  and causes ineffective, premature and non-infectious  virions  development.

ABSORPTION: Fast absorption from the GI tract, absorption increased with food, peak plasma concentration is approx  2-4hr for Ritonavir and lopinavir  approx 4 hours.

DISTRIBUTION: Minimal amount  distribution enters into CNS, volume of distribution about 0.16-0.66 L/kg. binding of plasma protein is approx 98% for Ritonavir and human serum protein for lopinavir is 98-99%.

METABOLISM: Ritonavir is mainly metabolized in liver by CYP3A4 & lesser  extent by  CYP2D6 isoenzymes and lopinavir metabolized in liver by oxidative metabolism.

ELIMINATION: Ritonavir eliminated via faeces approx 86% and 3.5% as unchanged drug via urine approx 11%. Lopinavir dose eliminated via approx 2.3% and 2.5% in feces and urine after 8 days.

 The terminal elimination half life is 3-5hr for Ritonavir and half life for lopinavir is 5 – 6 hrs

In Depth Information on Lopimune Tablet:

Expert Advice for Lopimune Tablets

Before taking lopimune, inform your doctors about as follows:

Patient with ischaemic heart disease, cardiomyopathy, pre-existing conduction abnormalities or structural heart disease, haemophilia A or B, porphyria, increased triglycerides.

Renal and severe hepatic impairment  without decompensation in Childern& Pregnancy. 

Monitoring Parameters Monitor cholesterol, triglycerides, CBC, LFTs, creatine phosphokinase, uric acid,viral load,CD4 count, serum amylase and lipase, glucose.

Body fat Aggregation, such as  obesity in central body, buffalo hump, wasting in facial , peripheral and  breast enlargement have been seen  in patients taking antiretroviral drug

Treatment with Lopimune , the patients may cause Worsening of diabetes mellitus and increase in glucose level, immune reconstitution syndrome,

Special Warnings of Lopimune Tablets


Alcohol interaction with Lopimune 200mg/50mg is unknown. Please consult the doctor.


Category B: Animal studies have been developed adverse effect, but sufficient and well-tolerated studies in pregnant women which have failed to develop a risk to the fetus in all trimester in pregnancy. Using the drug is unsafe to use during pregnancy.


Lopimune 200/50mg  is excreted into human milk. Breast feeding is not recommended while using the drug. According to some experts it is probably safe to use. Please consult the doctor.


If you feel any side effects like dizzy, tried. Avoid driving while using lopimune 200/50mg unless you feeling well.


Patients with kidney problem are probably safe to use. Limited data available with lopimune 200/50mg of dose adjustment may not be necessary. Please consult the doctor


 Patients with severe liver disease can be used with caution. Dosage adjustment is needed. In patients with mild to moderate liver disease has no dosage adjustment is needed. Please consult with the doctor.

Missed Dosage

As soon as you remember take the missed dose. If time for next dose then skips the missed dose and follow the routine scheduled. Do not take more than one tablet per day. Please consult your doctor for changes in dose or new schedule for replace of missed dose.


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Brand Name : <--------------------> Lopimune
Category : <--------------------> HIV Drugs
Sub Category :<--------------------> Lopinavir And Ritonavir
Company Name :<--------------------> Cipla Ltd
Ingeridents(Generic Name) :<--------------------> Lopinavir and Ritonavir
Dosage Form :<--------------------> 60 tablets
Package :<--------------------> 1X60
Strength :<--------------------> 200mg+50mg




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