Isentress


QUICK OVERVIEW

Generic Name : Raltegravir
Category : HIV Drugs
Company Name : MSD Pharmaceuticals PVT Ltd
Dosage Form: 60 tablets
Strength : 400mg

  

Availability: In Stock

Medicine Overview of Isentress Tablet


Uses of Isentress Tablet


Isentress 400mg in a class of medication called HIV integrase inhibitors

Isentress 400mg along with other medication is indicated for the treatment of human immune deficiency virus (HIV) infection.

By using these medication along with safer sex and making changes in other life- style may reduces the risk of spreading the HIV virus to other person

Side effects of Isentress Tablet


 Isentress 400mg will cause side effects such as

Common side effects:

Diarrhea

Heart burn

Insomnia

Abnormal dreams

Head pain

Some serious side effect also caused by Isentress 400mg

Muscle tenderness

Dark colored urine

Chest pressure                    

Skin blisters

Mouth lesions

Fast heartbeat

Yellowing of the skin or eyes

Pale stools

Drowsiness

Lack of energy

How to use Isentress Tablet


General dose: Isentress tablet have in film coated type and chewable type tablet

 Max dose of 300mg twice daily.

Isentress  is a chewable tablets may be chewed or swallowed whole. If film- coated tablets must be swallowed whole.

Do not substitute chewable tablet for the 400mg film coated tablet.

When combination with rifampin, the dose is 800mg twice daily

Both film coated and chewable are administrated with or without food.

For adult patients:

 Isentress  tablet is used to treat HIV-1 infection patients. The recommended dose is 400mg film coated tablet twice daily administrated orally.

For pediatric patients

The recommended dose for treatment of HIV-1 infection as follow:

12yrs of age and older: one tablet of 400mg fim coated tablet BD orally

6 to < 12yrs: If patients weighing of  atleast 25kg, dose is one tablet of 400mg BD orally

If patient weighing < 25kg then chewable tablet max dose 300mg BD

2 to < 6 yrs: If patients weighing atleast 10kg then dose is 300mg BD orally.

How to Isentress Tablet works:


Isentress 400mg  prevents the catalytic function of HIV-1 integrase,

An HIV-1 encoded enzyme which needed for viral multiplication. Inhibition of integrase interferes with the covalent insertion.

The provirus is necessary to direct the production of progeny virus, so blocks integration prevents propagation of the viral infection.

Isentress  including DNA polymerases α, β, and γ. I will not automatically prevents human phosphoryltransferases

Absorption: absorbed from GI tract. Peak plasma concentration of isentesis is 3 hrs post dose, bioavailability is not established

Effect of food: Isentress  is effective when administrated with or without food.

Distribution : Isentress has 83% bound to human plasma

Metabolism : Isentress is metabolized in liver (UGT1A1)

Excretions eliminated via feces of 51% and urine of 32%.

The half life is 9 hours


In Depth Information on Isentress Tablet:


Expert Advice for Isentress Tablets


  • Inform your health care provisional that if you are allergic to any of the ingredients in raltegravir tablets. Check  the Medication Guide for a list of the ingredients.
  • Inform your health care provisional which are using previous other prescription and nonprescription regimens; vitamins, nutritional supplements, and herbal products which are going to use / planning foradministrating the drug.. Be sure to mention any of the following: atovaquone,Emtricitabine, ganciclovir (Cytovene), interferon alpha, medications for cancer, methadone , nelfinavir (Viracept), and valproic acid (Depakene). Your doctor require to change the drug doses .
  • Inform your health care provisional about being treted with dialysis.if you either have any of the conditions mentioned in the important warning section; hypertension; hyperlipidimea; diabetes; or cardiac or renal disease.
  • Inform your health care provisional  that are you pregnant/plan to become pregnant/ breastfeeding. If you become pregnant while taking abacavir, lamivudine, call your doctor. Do not breastfeed  while  taking abacavir & lamivudine or infected by HIV infection
  • Persons should known that While taking HIV infection medication, the immune system get stronger to fight against  other infection in your body.It develop new or worsening symptom during the treatment

Special Warnings of Isentress Tablets



Alcohol


Alcohol interaction is not known. Please consult with your doctor

Pregnancy


Isentress 400mg has pregnancy category C no sufficient and well- tolerated studies of this drug in pregnant women. Isentress  400mg should not be used during pregnancy only If possible benefit justifies the possible risk to the fetus

Lactation


While on treatment with Isentress 400mg breast feeding is not recommended. Its necessary mother breast feeding their infants to avoid risk of transmission.

Driving


Isentress 400MG has side effects of dizzy, sleepy, tried or reduce alertness. So avoid driving unless you feeling well.



Kidney


Patients with kidney problem are probably safe to use. Limited data available with Isentress 400mg of dose adjustment may not be necessary. Please consult the doctor

Liver


Patients with severe liver disease can be used with caution. Dosage adjustment is needed. In patients with mild to moderate liver disease has no dosage adjustment is needed. Please consult with the doctor.



Missed Dosage


As soon as you remember take the missed dose. If time for next dose then skips the missed dose and follow the routine scheduled. Do not take more than one tablet per day. Please consult your doctor for changes in dose or new schedule for replace of missed dose.

 



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Isentress

 
Brand Name : <--------------------> Isentress
Category : <--------------------> HIV Drugs
Sub Category :<--------------------> Raltegravir
Company Name :<--------------------> MSD Pharmaceuticals PVT Ltd
Ingeridents(Generic Name) :<--------------------> Raltegravir
Dosage Form :<--------------------> 60 tablets
Package :<--------------------> 1X60
Strength :<--------------------> 400mg

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