Medicine Overview of Tafero EM Tablet
Uses of Tafero EM Tablet
Tafero EM which contain combination of Emtricitabine 200mg and Tenofovir Alafenamide 25mg with other antiretroviral agents for the treatment of HIV- 1 infection in the adult and pediatric patients weighing atleast 35kg.
Side effects of Tafero EM Tablet
Allgeric reaction: rash, hives, itching, red, swollen, blistered or peeling skin with or without fever, chest tightness, breathing trouble.
Kidney problems: ddifficulty in urine passing, urine colour changed, blood in urine
Liver problems: dark urine, not hungry, stomach upset, throwing up or yellow skin or eyes.
High lactic acid in the blood: fast breathing, fast heartbeat, feeling very sleep, shortness of breath, very bad dizziness, muscle cramps.
How to use Tafero EM Tablet
Tafero Em is recommended one tablet of Emtricitabine 200mg and Tenofovir alafenamide 25mg once in a day
Tafero Em administrated with or without food in adults and pediatric patients with body weight at least 25 kg.
How to Tafero EM Tablet works:
A synthetic nucleoside coordinate of cytidine is called emtricitabine, that go via phosphorylation occurring in- vitro cell to emtricitabine 5'-triphosphate, then take part with deoxycytidine 5'-triphosphate and is incorporated into viral DNA which leads to chain termination. Emtricitabine activity against HIV-1, HIV-2 viruses and hepatitis B virus (HBV).
Tenofovir Alafenamide (Tafero EM 25mg) is a inhibitor of Nucleotide reverse transcriptase that fight against viral infection . which act as an Phosphonamidate prodrug, then Tenofovir is hydrolized in vivo and then phosphorylated to the active metabolite to form Tenofovir diphosphate. Drug will prevents the reproduction of HIV virus in human cells and then stops the HIV virus from producing new viruses and a novel ester prodrug of the antiretroviral tenofovir, use to treat HIV infection and chronic hepatitis B.Tafero EM 25mg cause fast chain termination and interferes with proviral DNA 27 transcription.
Absorption: Tenofovir alafenamide Peak plasma concentration is approx 0.5hrs after the dose. Food effect: Tenofovir alafenamide with a high fat meal increase AUC compared with administration in fasted state. Emtricitabine bioavailability is 93% peak plasma concentration is 1-2 hrs.
Distribution: Tenofovir Alafenamide has Plasma protein binding is 80% and Emtricitabine human plasma bounding is <4%
Metabolism : Only minimal metabolized by CYP3A and Emtricitabine has limited metabolism
Elimination : Excreted by kidneys, 32% of dose in feces and<1% excreted in urine. Half life is 0.5hrs.while excretion in emtricitabine is highly unchanged in urine and low limited in feaces and half life is 10hrs
In Depth Information on Tafero EM Tablet:
Expert Advice for Tafero EM Tablets
When HIV-1 and HBV are coinfected in patients will leads to severe acute exacerbation of hepatitis B.
Lactic acidosis and severe hepatomegaly with steatosis used in combination with other ARTs cause fatal cases.
New onset worsening renal impairment with Tenofovir will produce acute renal failure.
Special Warnings of Tafero EM Tablets
Alcohol interaction with tafero Em is not know please consult with doctor.
Tafero EM 200mg/ 25mg during pregnancy is probably safe to use. There are limited human studies and Animal studies have shown no adverse effect on the fetus. Please consult the doctor.
Tafero EM has excreted in human milk. Since it is potent HIV transmission and severe adverse effects in nursing infants, feeding mother should be advice not to feed their infants.
Tafero EM has side effects of dizzy, sleepy, tried or reduce alertness. So avoid driving unless you feeling well.
Patients with kidney problem Tafero EM are used with caution. Dose adjustment is required . please consult your doctor.
Patients with hepatic disease are probably safe to use Tafero EM. Dose adjustment is necessary. Please consult with doctor.
As soon as you remember take the missed dose. If time for next dose then skips the missed dose and follow the routine scheduled. Do not take more than one tablet per day. Please consult your doctor for changes in dose or new schedule for replace of missed dose.
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Brand Name : <--------------------> Tafero EM
Category : <--------------------> HIV Drugs
Sub Category :<--------------------> Tenofovir Alafenamide And Emtricitabine
Company Name :<--------------------> Hetero Drugs Ltd.
Ingeridents(Generic Name) :<--------------------> Tenofovir Alafenamide and Emtricitabine
Dosage Form :<--------------------> 30 TABLETS
Package :<--------------------> 1X30
Strength :<--------------------> 200mg + 25mg