Medicine Overview of Tavin EM Tablet
Uses of Tavin EM Tablet
Tavin-EM 300mg/200mg is used with combination of antiretroviral drug or alone medicine in adult and children 12yrs / >12yrs for the treatment of HIV-1 infection.
Side effects of Tavin EM Tablet
severe hepatomegaly with steatosis
GI events: Anorexia, abdominal distention, diarrhea, dyspepsia, flatulence
raised liver enzyme,
How to use Tavin EM Tablet
Dose in adults and pediatric patients 12 years of age and older
HIV-1 or chronic hepatitis B: dose is 300mg Tavin EM, orally once daily, without regard to food.
Patients unable to swallow – 7.5 scoops oral powder formulation
Pediatrics for chronic hepatitis B – safety and efficacy have not been established.
Pediatric patients 2 years to < 12years
HIV-1 : dose of Tavin EM is 8 mg/kg/body weight OD administrated as oral powder or tablets.
For CHB : safety and efficacy have not been established younger than 12 years.
How to Tavin EM Tablet works:
A synthetic nucleoside coordinate of cytidine is called emtricitabine, that go via phosphorylation occurring in- vitro cell to emtricitabine 5'-triphosphate, then take part with deoxycytidine 5'-triphosphate and is incorporated into viral DNA which leads to chain termination. Emtricitabine activity against HIV-1, HIV-2 viruses and hepatitis B virus (HBV). An acyclic nucleoside phosphonate di ester associate of adenosine monophosphate is Tenofovir Disoproxil Fumarate (Tavin EM), that hydrolysed to Tenofovir, finally cellular enzymes phosphorylated to form Tenofovir diphosphate, an restrict chain terminator. Tenofovir involves with DNA synthesis of HIV through aggressive inhibition of reverse transcriptase and fusion into viral DNA. Tenofovir also prevents hepatitis B virus polymerase, resulting in blockage of viral replication.
Tavin EM (emtricitabine) , bioavailability is 93%(capsulel) and solution 75%, PPC is 1-2 hrs .
Tavin EM (Tenofovir) immediately absorbs from the GI tract, bioavailability is 25% approximately and time to peak plasma concentration (PPC) is 1-2hr..
Tavin EM (Tenofovir) volume of distribution is 1.2-1.3 L/kg and plasma protein binding is <1%,
In Tavin EM (Emtricitabine) independent of concentration and protein binding is <4%.
Tavin EM (Tenofovir Disoproxil Fumarate) ,that hydrolyzed to Tenofovir, finally cellular enzymes phosphorylated to form Tenofovir diphosphate, an restrict chain terminator. In
Tavin EM (Emtricitabine) is limited metabolism.
Tavin EM ( Tenofovir) excreted through urine by active glomerular filtration and tubular secretion and half life is 18hr.
Tavin EM (Emtricitabine) eliminated highly unchanged in urine and low limit in faeces, half life is 10hr.
terminal half life is 52-76hr(single dose) and 40-55hr (multiple dose).
In Depth Information on Tavin EM Tablet:
Expert Advice for Tavin EM Tablets
Before administration of Tavin Em, Patients should take care of these caution as follows:
- Patient with hepatomegaly or other serious factors for liver disease, Renal impairment, Pregnancy.
- Patient Counseling: This drug may cause dizziness, if affected, do not drive or operate machinery.
- Monitoring Parameters: Check the renal function and serum phosphate concentrations before start of the treatment, 4 weekly during the 1st week, and then 3 monthly.
- Hepatic function for several months following discontinuation. Determine HIV status in all hepatitis B virus (HBV) infected patients before the treatment.
Special Warnings of Tavin EM Tablets
Alcohol interaction with Tavin EM is unknown. Please consult with doctor
Tenofovir and Emtricitabine ( Tavin-EM ) has category B: the drug is preferably safe to use in pregnancy. Animal studies have been developed adverse effect, but sufficient and well-tolerated studies in pregnant women which have failed to develop a risk to the fetus in all trimester in pregnancy
Tavin – EM is preferably safe to use while breast feeding. Limited data is advice for specific risk for the baby.
Tavin Em will affect your ability to drive due to the side effects like dizzy, sleepy, tried, alertness decreased. Avoid driving unless you feel well.
Tavin EM is used with caution for the patients having kidney problem.dose adjustment is required . Please consult with the doctor.
Patients with mild to moderate hepatic problem are preferably safe to use Tavin Em tablet. Limited data available suggests that dose adjustment of Tavin EM Tablet may not be required in these patients. Please consult with your doctor.
As soon as you remember take the missed dose. If time for next dose then skips the missed dose and follow the routine scheduled. Do not take more than one tablet per day. Please consult your doctor for changes in dose or new schedule for replace of missed dose.
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Brand Name : <--------------------> Tavin EM
Category : <--------------------> HIV Drugs
Sub Category :<--------------------> Tenofovir Disoproxil Fumarate / Emtricitabine
Company Name :<--------------------> Emcure pharmaceuticals Ltd
Ingeridents(Generic Name) :<--------------------> Tenofovir Disoproxil fumarate and Emtricitabine
Dosage Form :<--------------------> 30 TABLETS
Package :<--------------------> 1X30
Strength :<--------------------> 300mg + 200mg