Tenof Em


QUICK OVERVIEW

Generic Name : Tenofovir Disoproxil Fumarate / Emtricitabine
Category : HIV Drugs
Company Name : Hetero Drugs Ltd.
Dosage Form: 30 TABLETS
Strength : 300mg + 200mg

  

Availability: In Stock

Medicine Overview of Tenof Em Tablet


Uses of Tenof Em Tablet


Tenof - EM 300mg/200mg  is used with combination of antiretroviral drug or alone medicine in adult and children 12yrs / >12yrs for the treatment of HIV-1 infection.

Side effects of Tenof Em Tablet


Major effects:

Lactic acidosis,

severe hepatomegaly with steatosis

 Renal effects:

Nephritis,

 Nephrogenic,

diabetes insipidus,

renal failure

GI events: Anorexia, abdominal distention, diarrhea, dyspepsia, flatulence

Common effects:

vertigo, fatigue,

raised liver enzyme,

athralgia,

rhabdomyolysis,

osteomalacia.

How to use Tenof Em Tablet


Dose in adults and pediatric patients 12 years of age  and older

HIV-1 or chronic hepatitis B: dose is 300mg Tenof - EM, orally once daily, without regard to food.

Patients unable to swallow – 7.5 scoops oral powder formulation

Pediatrics for chronic hepatitis B – safety and efficacy have not been established.

Pediatric patients 2 years to < 12years

HIV-1 : dose of Tenof EM is 8 mg/kg/body weight OD administrated as oral powder or tablets.

For CHB : safety and efficacy have not been established younger than 12 years.

How to Tenof Em Tablet works:


A synthetic nucleoside coordinate of cytidine is called emtricitabine, that  go via  phosphorylation occurring in- vitro cell to emtricitabine 5'-triphosphate, then take part  with deoxycytidine 5'-triphosphate and is incorporated into viral DNA which leads to  chain termination. Emtricitabine activity against HIV-1, HIV-2 viruses  and hepatitis B virus (HBV). An acyclic nucleoside phosphonate di ester associate  of adenosine monophosphate is Tenofovir Disoproxil Fumarate (Tenof - EM), that  hydrolysed to Tenofovir, finally  cellular enzymes phosphorylated  to form Tenofovir diphosphate, an restrict  chain terminator. Tenofovir  involves  with  DNA synthesis of HIV through aggressive inhibition of reverse transcriptase and fusion into viral DNA. Tenofovir  also prevents  hepatitis B virus polymerase, resulting in blockage  of viral replication.

ABSORPTION:

  •  Tenof - EM (emtricitabine) , bioavailability is 93%(capsulel) and solution 75%, PPC is 1-2 hrs .

  • Tenof - EM (Tenofovir) immediately absorbs from the GI tract, bioavailability is 25% approximately  and time to peak plasma concentration (PPC) is 1-2hr..

DISTRIBUTION:

  • Tenof - EM (Tenofovir)  volume of distribution is 1.2-1.3 L/kg and plasma protein binding is <1%,

  • In Tenof - EM (Emtricitabine)  independent of concentration and protein binding is <4%.

METABOLISM:

  • Tenof - EM (Tenofovir Disoproxil Fumarate) ,that  hydrolyzed to Tenofovir, finally  cellular enzymes phosphorylated  to form Tenofovir diphosphate, an restrict  chain terminator. In

  • Tenof - EM (Emtricitabine)  is limited metabolism.

ELIMINATION:

  • Tenof - EM ( Tenofovir) excreted through urine by active glomerular filtration and tubular secretion and half life is 18hr.

  • Tenof - EM (Emtricitabine)  eliminated highly unchanged in urine and low limit in faeces, half life is 10hr.

  • Terminal half life is 52-76hr(single dose) and 40-55hr (multiple dose).


In Depth Information on Tenof Em Tablet:


Expert Advice for Tenof Em Tablets


  Before administration of Tenof - EM, Patients should take care of these caution as follows:

  • Patient with hepatomegaly or other serious factors for liver disease, Renal impairment, Pregnancy. 

  • Patient Counseling: This drug may cause dizziness, if affected, do not drive or operate machinery. 

  • Monitoring  Parameters:  Check the renal function and serum phosphate concentrations before start of the treatment, 4 weekly during the 1st week, and then 3 monthly.

  • Hepatic function for several months following  discontinuation. Determine HIV status in all hepatitis B virus (HBV) infected patients before the treatment.


Special Warnings of Tenof Em Tablets



Alcohol


Alcohol interaction with Tenof EM is unknown. Please consult with doctor

Pregnancy


  Tenofovir and Emtricitabine (Tenof - EM)  has category B: the drug is preferably safe to use in pregnancy. Animal studies have been developed adverse effect, but sufficient and well-tolerated studies in pregnant women which have failed to develop a risk to the fetus in all trimester in pregnancy.

Lactation


Tenof - EM is preferably safe to use while breast feeding. Limited data is advice for specific risk for the baby.

Driving


Tenof - EM will affect your ability to drive due to the side effects like dizzy, sleepy, tried, alertness decreased. Avoid driving unless you feel well.



Kidney


 Tenof - EM is use with caution for the patients having kidney problem.dose adjustment is required . Please consult with the doctor

Liver


Patients with mild to moderate hepatic problem are preferably safe to use Tenof - EM tablet. Limited data available suggests that dose adjustment of  Tenof - EM Tablet may not be required in these patients. Please consult with your doctor.



Missed Dosage


 As soon as you remember take the missed dose. If time for next dose then skips the missed dose and follow the routine scheduled. Do not take more than one tablet per day. Please consult your doctor for changes in dose or new schedule for replace of missed dose.

 



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Tenof Em

 
Brand Name : <--------------------> Tenof Em
Category : <--------------------> HIV Drugs
Sub Category :<--------------------> Tenofovir Disoproxil Fumarate / Emtricitabine
Company Name :<--------------------> Hetero Drugs Ltd.
Ingeridents(Generic Name) :<--------------------> Tenofovir Disoproxil fumarate and Emtricitabine
Dosage Form :<--------------------> 30 TABLETS
Package :<--------------------> 1X30
Strength :<--------------------> 300mg + 200mg

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