Medicine Overview of Hepcinat LP Tablet
Uses of Hepcinat LP Tablet
Hepcinat LP 90mg/400mg used for long lasting a viral infection of the liver “Hepatitis C”( a chronic condition). By combination therapy, It is used with other antiviral drug (ribavirin). Hepcinat LP tablet minimize the amount of hepatitis C virus in body in which help to improve immune system by fighting against infection and also recover the liver infections.
Side effects of Hepcinat LP Tablet
Hepcinat LP 90mg/400mg ranges from mild to severe condition and risk can varies from person to person.
- Appetite loss
- Difficulty to concentrate
- irregular heartbeat
- Weakness & head pain
- Discomfort in chest
- Loss of consciousness
How to use Hepcinat LP Tablet
Hepcinat LP 90mg/400mg tablet is indicated for chronic hepatitis C viral infection.
In adult dose recommended is ledipasvir 90mg and Sofosbuvir 400mg of one tablet, once in a day. Hepcinat LP can be given with or without food for 12weeks duration.
For genotype1,4,5 and 6 : Treatment of new or experienced patients without cirrhosis or with compensated cirrhosis used with coexistent ribavirin in eligible patients for 12 weeks.
For genotype 1 and 4 : Liver transplant recipients for new or experienced patients without cirrhosis or with compensated cirrhosis used with coexistent ribavirin in eligible patients for 12 weeks.
Geriatric dose : Same as adult dose.
Pediatric dose: 1 tablet of Hepcinat LP 90mg/400mg once daily for children and adolescents ≥ 12 years or weight ≥35kg.
Overdose: Hepcinat LP overdose has no specific antidote available.If occurs should monitored for evidence of toxicity or seek to emergency medical attention or call the poison help line Contact 1-800-222-1222.
How to Hepcinat LP Tablet works:
Hepcinat LP 90mg/400mg has an possibility of direct interfere with the proliferation of hepatitis C virus by its own. Hepcinat LP a fixed dose combination of 2 direct acting antiviral drug . Because of both drug combinations, it targets different stages in cycle. Ledipasivir , an NS5A inhibitor which works by prevent by a protein needed to finish the life cycle of Hepatitis C virus in the liver cell, and the other Sofosbuvir 400mg is an inhibitor of nucleotide polymerase, in turn prevents the replication of virus’s genetic material. Sofosbuvir stops the new production of HCV.
Absorption: Well absorbed and peak plasma concentration of ledipasvir is 4 – 4.5 hr post dose and Sofosbuvir is 0.8 -1 he post dose.
Distribution: Plasma protein binding of ledipasvir >99.8% and Sofosbuvir is 61% to 65%
Metabolism: Ledipasvir metabolism was observed by human is CYP1A2,CYP2C8,CYP2C9,CYP2C19,CYP2D6,CYP3A4
Primarily Sofosbuvir mobilized in the liver in the forms of pharmacologically active nucleoside analog triphosphate GS-461203.
Excretion: Ledipasvir elimination via feces (-86%) and urine (1%) and for Sofosbuvir via urine (80%) and feces (14%).
Half life elimination of Ledipasvir is 47hrs and Sofosbuvir is -0.5hrs.
In Depth Information on Hepcinat LP Tablet:
Expert Advice for Hepcinat LP Tablets
The treatment of Hepatitis C for most of the patient, Hepcinat LP is high curing medicine.In some we cannot use this drug.
- Avoid Hepcinat LP, If patient on treatment of ledipasvir or sofobuvir and other combination contain sofobuvir.
In some cases inform your doctor before using Hepcinat LP
- If pregnant or planning or breast feeding
- If taking prescription /nonprescription/herbal drug/nutritional supplements.
- If allergy to other medicine or food
- If patient affected by kidney or liver problem
Special Warnings of Hepcinat LP Tablets
Hepcinat LP 90mg/400mg interaction with alcohol is not specified. For further details please consult your physician.
Pregnancy category B: In studies of Animal reproduction that have been failed to described a risk to the fetus and have been shown Interferon’s have Abortifacient effects, there are no adequate and well-controlled studies in pregnant women. Hepcinat LP 90mg/400mg with Ribavirin will affect the Birth Defects and Fetal Death. Avoid in pregnant women and male partner. Patients should check Negative Pregnancy Test before starting the treatment. Use 2 Effective Methods Of Contraception and check monthly Pregnancy Tests.
Hepcinat LP 90mg/400mg amount in human milk is very low and is highly bound to maternal plasma proteins. If mother require this drug then its not necessary to discontinue the drug. May be some doctor prescribe against breast feeding when its combine with ribavirin.
While using of Hepcinat LP 90mg/400mg with combination of other antiviral drug will cause dizziness, blurred vision and may affect the ability to drive. Avoid using Hepcinat LP during driving until you are feeling well.
Patient with severe kidney disease, Hepcinat LP 90mg/400mg should be used with caution and dose adjustment is required. Check up with doctor. When mild to moderate kidney disease, Hepcinat LP 90mg/400mg do not require dose adjustment in those patients.
Mild, moderate or severe liver problem in patients have no dose adjustment, safe to use Hepcinat LP 90mg/400mg with liver disease. But patient with decompensated cirrhosis using this drug plus ribavirin then clinical and hepatic monitoring is recommended.
As soon as you remember take the missed dose. If time for next dose then skips the missed dose and follow the routine scheduled. Do not take more than one tablet per day. Please consult your doctor for further details.
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Brand Name : <--------------------> Hepcinat LP
Category : <--------------------> Hepatitis Drugs
Sub Category :<--------------------> Sofosbuvir-Ledipasvir
Company Name :<--------------------> Natco
Ingeridents(Generic Name) :<--------------------> Sofosbuvir + Ledipasvir
Dosage Form :<--------------------> 28
Package :<--------------------> 3x28
Strength :<--------------------> 400mg + 60mg