Velasof


QUICK OVERVIEW

Generic Name : Sofosbuvir-Velpatasvir
Category : Hepatitis Drugs
Company Name : Hetero
Dosage Form: 28 Tablets
Strength : 400mg +100mg

  

Availability: In Stock

Medicine Overview of Velasof Tablet


Uses of Velasof Tablet


 

Velasof is a direct acting antiviral which is indicated for the treatment of chronic hepatitis C virus genotype 1 to 6 infection in adult, It may be

  • With compensated cirrhosis/ without cirrhosis
  • With decompensated cirrhosis by using ribavirin combination

Side effects of Velasof Tablet


 Velasof cause mild to severe side effects, it depends on each patient’s reaction to treatment

Signs of an allergic problem with Velasof like breathing trouble,swelling of your face, lips, tongue or throat, hives

Common effects: Discouragement, sleeping and concentration in trouble, irritability, feeling empty, loss of strength, decreased appetite.

Serious side effects: Chest discomfort, dyspnea, irregular heartbeat, dizziness, unusual tiredness, unconsciousness.

How to use Velasof Tablet


In adult, Velasof used for the treatment of chronic hepatitis C , I require dose of Velpatasvir 100mg and Sofosbuvir 400mg, 1 tablet taken orally once daily.

If patient with compensated cirrhosis and without cirrhosis (child-pugh A) : Sofosbuvir – Velpatasvir for 12weeks.

If patient with decompensated cirrhosis (child – pugh B or C): Velasof plus ribavirin for 12 weeks.

Administer without regard to food.

For pediatric dose : safety and efficacy is not established <18years of age.

Overdose of Velasof : There no specific antidote available for overdose, If its occurs the patient should  check the presence of toxicity and provide supportive measure. Otherwise seek to the emergency medical and call poison helpline immediately.

How to Velasof Tablet works:


Velpatasvir  (Velasof) is a antiviral regimen which is an inhibitors of HCV NS5A protein and needed  for viral multiplication. Resistance collection in cell culture and cross-resistance studies express velpatasvir binds the NS5A as its mode of action and its directly helps  for replication of hepatitis C virus by blocking the binding of two protein essential. "NS5B RNA-dependent RNA polymerase" is an enzyme and its action is inhibited by Sofosbuvir drug

Absorption: Oral administration, peak plasma concentration of Sofosbuvir is 0.5-1 hour after the dose and Velpatasvir peak plasma concentration is 3 hours after the dose

Administration of food with moderate fat or high fat meal both drugs (Sofosbuvir/Velpatasvir) increases the exposure Sofosbuvir (60 or 305 fat) and Velpatasvir (34 or21%) respectively

Distribution: human plasma protein binding of Sofosbuvir is 61-65% and Velpatasvir is >99.5% .

Metabolism: Sofosbuvir metabolized in liver by by GS-461203 and desphosphorylation leads to formation of GS-331007.Velpatasvir: Metabolized by CYP2B6, 2C8 and 3A4.

Elimination: Sofosbuvir major route is renal clearance via urine 80% and14% in feces and 2.5% in expired air. Velepatasvir major route is biliary excretion and dose eliminated 94% in feces and 0.4% in urine.

Half life of Sofosbuvir is 0.5hours, its GS-331007 is 25 hours and Velpatasvir is 15 hours.


In Depth Information on Velasof Tablet:


Expert Advice for Velasof Tablets


Consult with your doctor Before taking this Velasof consult with your doctor.

  • If you face any severe side effects also inform  the doctor such as:

Weekness ; Difficulty in concentrating ; Shallow breathing ;Rapid heart rate ; Reduce RBC

  • Patient should inform the doctor in case  taking the medication for heartburn or indigestion or any kind of ulcers[ H2 blockers]. Doctor may  continue with these medicines or he will inform to change the drug 12 hour prior or 12 hours after before consuming velasof and same while using herbal drugs also.
  • When Velasof co administered with amiodarone and other HCV drug causes serious symptomatic bradycardia.
  • Concomitant use with inducers of p-gp and potent of CYP will leads to risk of reducing therapeutic effect.
  • With ribavirin causes severe effect to unborn baby, avoid pregnancy.

Special Warnings of Velasof Tablets



Alcohol


Alcohol interaction with Velasof 400mg/100mg is unknown. Please consult with doctor for further details.

Pregnancy


Animal studies failed to publish the effect of fetal harm, in human pregnancy there is no sufficient and controlled data about fetal harm. Velasof 400mg/100mg with combination with ribavirin,it will harm unborn baby.

Lactation


If the breast feed mother need Velasof 400mg/100mg no need of discontinue the breast feeding for this reason but some physician may suggest to stop during drug used with ribavirin. According to them use of drug is not recommended. Exretion into human milk is unknown and in animal milk is excreted.

Driving


On treatment with Velasof 400mg/100mg , without feeling well do not go for drive because when Velasof co administration with other medicine for treatment of hepatitis C, It may produce vertigo and blurred vision and also affect driving ability



Kidney


Kidney problem with mild to moderate renal impairment have no dose adjustment required and patient with severe problem or ESRD require dose adjustments and use the Velasof 400mg/100mg with caution.please consult with doctor before using drug.

Liver


Velasof 400mg/100mg is safe to use with hepatic problem. No dose adjustment required for those patient. For further information consult with your doctor. But for some patients liver function test should be monitor on treatment with Velasof  tablet.



Missed Dosage


As soon as you remember take the missed dose. If time for next dose then skips the missed dose and follow the routine scheduled. Do not take more than one tablet per day. Please consult your doctor for further details.



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Velasof

 
Brand Name : <--------------------> Velasof
Category : <--------------------> Hepatitis Drugs
Sub Category :<--------------------> Sofosbuvir-Velpatasvir
Company Name :<--------------------> Hetero
Ingeridents(Generic Name) :<--------------------> Sofosbuvir + Velpatasvir
Dosage Form :<--------------------> 28 Tablets
Package :<--------------------> 3x28
Strength :<--------------------> 400mg +100mg

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