Hepcvel


QUICK OVERVIEW

Generic Name : Sofosbuvir-Velpatasvir
Category : Hepatitis Drugs
Company Name : Cipla
Dosage Form: 28 Tablets
Strength : 400mg & 100mg

  

Availability: In Stock

Medicine Overview of Hepcvel Tablet


Uses of Hepcvel Tablet


Hepcvel 400mg/100mg is used to treat chronic Hepatitis C infection in adults. It fights against the infection and helps to improve immune system and easily recover of liver problem. Hepcvel 400mg/100mg is indicated for the treatment of  patients who are suffered with chronic hepatitis C viral infection associated genotype I, II, III, IV, V or VI infection without cirrhosis or with compensated cirrhosis. Hepcvel with ribavirin use decompensated cirrhosis.

Side effects of Hepcvel Tablet


Hepcvel 400mg/100mg have some side effects. While taking Sofosbuvir/Velpatasvir, If any reaction occurs then check with your doctor immediately

  • Rashes in the body
  • Lack of energy
  • Feel irritated or depressed
  • Slow heartbeat
  • Insomnia
  • Decreased in RBC
  • Dyspnea
  • Chest discomfort

How to use Hepcvel Tablet


In adult one tablet of Hepcvel containing dose of Sofosbuvir 400mg and Velpatasvir 100mg taken orally. It can be used either alone or use it with ribavirin for the treatment.

  • It can take it with or without food.
  • On a daily basis the particular medicine should be take at same time
  • The person has to follow the directions as provided by Hepatologist or HCV treatment specialist in the prescription label.

For Paediatric: No safety and efficacy is recommended for <18yrs of age.

If overdose occurs: Hepcvel overdose has no specific antidote available, If it occur patient should monitor for evidence of toxicity and provide supportive measure treatment  including vitals, clinical status observation of patient or seek to emergency medical department or call poison control helpline

How to Hepcvel Tablet works:


Velpatasvir is  domine of NS5A inhibitors bind completely with RNA at this site. And also thought that NS5A inhibitors bind the target during its action in multiplication when the binding site is defined. Prevention of NS5A is also known to produce protein redistribution into lipid droplets. The role of NS5A in RNA reproduction is not yet clear.

Sofosbuvir (Hepcvel) act has an nucleotide analog inhibitor, It will specifically interfere with HCV NS5B (non-structural protein 5B) RNA-dependent RNA polymerase and followed by intracellular metabolism to form the pharmacologically active uridine analog triphosphate (GS-461203), Sofosbuvir associates into Hepatitis C virus RNA by the NS5B polymerase and acts as a chain terminator . Finally It will prevents viral proliferation by two Mg2+ions

 Absorption: Oral administration, peak plasma concentration of Sofosbuvir is 0.5-1 hour after the dose and Velpatasvir peak plasma concentration is 3 hours after the dose

 

Administration of food with moderate fat or high fat meal both drugs (Sofosbuvir/Velpatasvir) increases the exposure Sofosbuvir (60 or 305 fat) and Velpatasvir (34 or21%) respectively

Distribution: human plasma protein binding of Sofosbuvir is 61-65% and Velpatasvir is >99.5% .

Metabolism: Sofosbuvir metabolized in liver by by GS-461203 and desphosphorylation leads to formation of GS-331007.Velpatasvir: Metabolized by CYP2B6, 2C8 and 3A4.

Elimination: Sofosbuvir major route is renal clearance via urine 80% and14% in feces and 2.5% in expired air. Velepatasvir major route is biliary excretion and dose eliminated 94% in feces and 0.4% in urine.

Half life of Sofosbuvir is 0.5hours, its GS-331007 is 25 hours and Velpatasvir is 15 hours.


In Depth Information on Hepcvel Tablet:


Expert Advice for Hepcvel Tablets


         When Hepcvel co administered with amiodarone and other HCV drug causes serious symptomatic bradycardia.

Concomitant use with inducers of p-gp and potent of CYP will leads to risk of reducing therapeutic effect.

With ribavirin causes severe effect to unborn baby, avoid pregnancy

If you are taking the antacids, it is important for you to take them either four hours before or four hours after the  Hepcvel should consume either four hours before or 4 hours after the drug.


Special Warnings of Hepcvel Tablets



Alcohol


Alcohol interaction with hepcvel is unknown. Please consult with doctor for further details.

Pregnancy


Animal studies failed to publish the effect of fetal harm, in human pregnancy there is no sufficient and controlled data about fetal harm. Hepcvel with combination with ribavirin,it will harm unborn baby

Lactation


If the breast feed mother need this drug, no need of discontinue  the breast feeding for this reason but some physician may suggest to stop during hepcvel tablet used with ribavirin. According to them use of drug is not recommended. Exretion into human milk is unknown and in animal milk is excreted.

Driving


On treatment with Hepcvel 400mg/100mg , without feeling well do not go for drive because when Hepcvel co administration with other medicine for treatment of hepatitis C, It may produce vertigo and blurred vision and also affect driving ability



Kidney


Kidney problem with mild to moderate renal impairment have no dose adjustment required and patient with severe problem or ESRD require dose adjustments and use the hepcvel 400mg/100mg with caution.please consult with doctor before using drug.

Liver


Hepcvel 400mg/100mg is safe to use with hepatic problem. No dose adjustment required for those patient. For further information consult with your doctor. But for some patients liver function test should be monitor on treatment with hepcvel tablet.



Missed Dosage


As soon as you remember take the missed dose. If time for next dose then skips the missed dose and follow the routine scheduled. Do not take more than one tablet per day. Please consult your doctor for further details.



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Hepcvel

 
Brand Name : <--------------------> Hepcvel
Category : <--------------------> Hepatitis Drugs
Sub Category :<--------------------> Sofosbuvir-Velpatasvir
Company Name :<--------------------> Cipla
Ingeridents(Generic Name) :<--------------------> sofosbuvir and velpatasvir
Dosage Form :<--------------------> 28 Tablets
Package :<--------------------> 3x28
Strength :<--------------------> 400mg & 100mg

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