Entavir


QUICK OVERVIEW

Generic Name : Entecavir
Category : Hepatitis Drugs
Company Name : Cipla
Dosage Form: 30 TABLETS
Strength : 1mg

  

Availability: In Stock

Medicine Overview of Entavir Tablet


Uses of Entavir Tablet


Entevir 1mg which indicated to decrease quantity of hepatitis B virus.

        In adult Entavir 1mg  is used for the treatment of chronic hepatitis B virus infection with the indication of active viral reproduction and  either evidence of persistent elevations in serum aminotransferases (ALT OR AST).

        Its also used on clinical trial data in nucleoside inhibitor treatment for the HBeAg positive and HBeAg negative HBV infection.

Side effects of Entavir Tablet


  •  Headache
  • Muscle pain
  • Nausea and vomiting
  • Irregular heartbeat
  • Jaundice
  • Breathing difficulty
  • Stomach pain
  • Decrease Appetite
  • Colour changes in stools
  • Vertigo
  • Excessive level of acid in the body

How to use Entavir Tablet


 Entavir 1mg tablets with lamivudine or known lamivudine or telbivudine resistance substitions rtM204I/V with or without rtL180M, rtL80I/V, or rtV173L with past history of hepatitis B viremia in adult and adolescents (at least 16 years of age) the prescribed dose is 1 mg

Entavir  given one tablet of 1mg once daily.

Entavir 1mg administrated on an empty stomach for atleast 2hrs after a meal or before the next meal.

Pediatric dose :

2 to 15 years for therapy new patients.

10 to 11 kg: 0.15 mg orally once a day
>11 to 14 kg: 0.2 mg orally once a day

>14 to 17 kg: 0.25 mg orally once a day
>17 to 20 kg: 0.3 mg orally once a day
>20 to 23 kg: 0.35 mg orally once a day
> 23 to 26 kg: 0.4 mg orally once a day
> 26 to 30 kg: 0.45 mg orally once a day
> 30 kg: 0.5 mg orally once a day.

Lamivudine experienced patient:

10 to 11 kg: 0.3 mg orally once a day
>11 to 14 kg: 0.4 mg orally once a day
>14 to 17 kg: 0.5 mg orally once a day
>17 to 20 kg: 0.6 mg orally once a day
>20 to 23 kg: 0.7 mg orally once a day
>23 to 26 kg: 0.8 mg orally once a day
>26 to 30 kg: 0.9 mg orally once a day
>30 kg: 1 mg orally once a day

OVERDOSAGE: If patients had single entecavir  doses of 40mg or double dose of 20mg/day till 14days has no evidence of increase or any adverse effect. If overdose occurs then provide immediately supportive and symptomatic measurements such as vitals signs of toxicity of medicine

How to Entavir Tablet works:


               Entacavir is belongs to the classification of antiviral drug and an  nucleoside analogue show action against hepatitis B virus polymerase  is effectively phosphorylated to the active triphosphate form, which require an intracellular half life of 15 hours. Entavir tablet combination with natural substances such as deoxyguanosine triphosphate functionally prevents all three activities of HBV reverse transcriptase:             

  1. Base priming
  2. Ergonomic messenger RNA produce negative strand of reverse transcription
  3. Synthesis of positive strand of HBV DNA.

Entavir 1mg reduces the quantity of hepatitis virus in the blood  and  decrease the multiply  and infect new cells by these three activities.

Absorption: Entavir 1mg has peak plasma concentration between 0.5 and 1.5 hours and bioavailability is 100% relative to the oral solution.   Effect of food: while on empty stomach is more effective for tablet absorption compared to with food.

Distribution: binding to human plasma protein of entavir is 13 %

Metabolism: small amount of phase II metabolites (glucuronide and sulfate conjugates) were observed

Elimination: Entavir is widely excreted by the kidney with urinary unchanged drug recovery ranging from 62% to 73%.

Terminal elimination half life of Entavir 24 hours.  


In Depth Information on Entavir Tablet:


Expert Advice for Entavir Tablets


Before Using of Entevir tablet, inform your doctor about:

  • Allergic To Entecavir, any medication related to entecavir

  • If your on Other Prescription And Nonprescription Medications, as using of  Vitamins, Nutritional products, And Herbal supplements

  • If  you had any Liver Transplantation, AIDS, HIV, Or any Kidney Disease previously

  •  If You Are Pregnant Or planning for pregnancy or any other surgery have done.

  •  If Entavir treatment discontinue, Hepatitis may not be curable. This  will Happen Due to The First few Months after stopping of Entecavir.

  •  Take Entecavir tablet  correctly as adviced by doctor.


Special Warnings of Entavir Tablets



Alcohol


Alcohol interaction with the drug  Entavir 1mg is not known. Please consult your doctor for any inconveniency.

Pregnancy


Pregnancy category C: Entavir 1mg may not be safe to use during pregnancy. In studies of animal reproduction has shown adverse effects on the fetus, in human studies has no adequate and well controlled data but probable benefits may permit to use the drug in pregnant women against possible risks.

Lactation


While breastfeeding, taking into account of serious of the drug to the mother an decision should be made to discontinue the drug or discontinue breastfeeding. Excreted into human milk is unknown and in animal milk its excreted. 

Driving


Entavir 1mg cause side effects of dizzy, sleepy, tried or reduce alertness. If this you feel then avoid driving until you feeling well.



Kidney


Patient with kidney problem use the Entavir 1mg with caution. Dosage adjustment is required in renal impairment. Please consult the doctor for further clarifications.

Liver


  Patient with hepatic impairment have no dosage adjustment is Necessary in Entavir 1mg Tablet.           



Missed Dosage


  If you missed a dose take it as soon as possible, if time reach for next dose, then skip missed dose and continue regular schedule. Do not take extra or double dose.



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Entavir

 
Brand Name : <--------------------> Entavir
Category : <--------------------> Hepatitis Drugs
Sub Category :<--------------------> Entecavir
Company Name :<--------------------> Cipla
Ingeridents(Generic Name) :<--------------------> Entecavir
Dosage Form :<--------------------> 30 TABLETS
Package :<--------------------> 1X30
Strength :<--------------------> 1mg

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