Zecyte


QUICK OVERVIEW

Generic Name : Abiraterone Acetate
Category : Anti-Cancer Drugs
Company Name : Cipla
Dosage Form: 120 tablets
Strength : 250mg

  

Availability: In Stock

Medicine Overview of Zecyte Tablet


Uses of Zecyte Tablet


Zecyte 250mg tablet is mainly used with the combination with prednisone to treat the patients with suffering from;

  • Metastatic castration-resistant prostate cancer (CRPC)

  • Metastatic high – risk castration sensitive prostate cancer (CSPC)

Side effects of Zecyte Tablet


 Side effects are more common in Zecyte (>30% occurring)

  • Heartburn
  • Groin pain
  • Hot flashes
  • Retention of fluid
  • Triglycerides increased
  • Increased liver enzyme

Serious side effects of  zecyte (10-29% occurring)

  • Reduce appetite
  • Blood in urine
  • Painfull urination
  • Swelling of joints
  • Decreased potassium levels
  • Swelling of hands/ feets
  • Muscle discomfort
  • Phosphorus level reduced
  • UTI
  • Fast heartbeats
  • Confusion

How to use Zecyte Tablet


  • Prescribed dose of Zecyte  tablet is 1,000 mg, Zecyte 250mg given 4 dose orally once in a day (OD). 
  • Zecyte 250mg tablet in Combination with prednisone 5 mg administered orally twice daily. 
  • Zecyte 250mg tablet administrated on an empty stomach.
  • No food should be consumed for at least 2 hours before and at least 1 hour after the dose of zecyte Tablets  is taken.
  • Zecyte 250mg tablet should be swallowed whole with water.
  • Do not crush or chew the tablets.

OVERDOSAGE: Zecyte 250mg has no specific antidote, If overdose occurs stop the drug and provide general supportive measures such as monitoring arrhythmias and cardiac failure and assess liver function

How to Zecyte Tablet works:


A type of  steroidal enzyme inhibitor CYP17A1 (17 alpha-hydroxylase/C17,20 lyase) is known as abirateron acetate which is an orally active and It interefere with  CYP17A1 in a selective and invariable manner  through covalent binding mechanism. An enzyme CYP17A1  which catalyzes the biosynthesis of androgen and is highly expressed in testicular, adrenal, and prostatic tumor tissue. Particularily , abiraterone prevents  the conversion of 17-hydroxyprognenolone to dehydroepiandrosterone (DHEA) by the enzyme CYP17A1 to reduce  serum levels of testosterone and other androgens.

Absorption: poorly absorbed and hydrolysis by esterases. Zecyte tablet 250mg is a salt form, is a prodrug and have higher oral bioavailability. Time for peak plasma concentration is 1.5 – 4 hours. Food and high fat meals increases absorption.

Distribution: >99% protein bound to alpha – 1- acid glycoprotein and albumin

Metabolism : Zecyte tablet by  hydrolyzation and It  is converted into active metabolite Abiraterone through esterases. CYP3A4 and SULT2A1 is metabolizes into two inactive metabolites called Abiraterone sulfate and N-oxide Abiraterone sulfate.

Elimination: excreted through feces (88%) and urine (5%). Terminal half life is 5-14hours.


In Depth Information on Zecyte Tablet:


Expert Advice for Zecyte Tablets


  • Avoid taking another medications, i.e prescription, over-the-counter, vitamins, herbal remedies, etc be sure to inform the doctors before the treatment. Avoid aspirin administering and products containing aspirin till doctor particularily  allow the drug

  • While using this medicine, the fertility in men is decreased. So discuss with doctor about the risk of medicine

  • Unknown process of Zecyte tablet is eliminated in semen, hence do not use condom and another method of birth control by men during treatment and for 1 week following the last dose of abiraterone acetate.

  •  In women Abiraterone acetate (zecyte) is not currently used. so if abiraterone acetate is taken by woman, avoid  getting pregnant  and avoid breast feed during treatment.


Special Warnings of Zecyte Tablets



Alcohol


Zecyte 250mg tablet interaction with alcohol is not known. Please consult with your doctor.

Pregnancy


Category X: Abiraterone acetate (Zecyte) is not recommended for womens, It will cause fetal harm when administered to pregnant women. During treatment if women become pregnant, immediately stop the drug and give counseling to the women.

Lactation


Zecyte 250mg tablet is not used in women,  excretion in human milk is unknown and the drug effects in the nursing infant is unknown.

Driving


Zecyte 250mg tablet is safe while using on driving. It dose not usually affects your ability to drive. 



Kidney


Zecyte 250mg tablet is safe to use in patients with mild moderate  kidney disease. No dosage adjustment required for patients. In patients with severe kidney disease limited use with caution.

Liver


 No dosage adjustment required in patients with baseline mild liver disease. Avoid using of  Zecyte 250 mg tablet while patients with baseline severe hepatic impairment . Dose adjustment may be required. Please  consult with your doctor.



Missed Dosage


The drug dose is missed, then take the drug dose as soon as possible. If next dose time arrived then skip the missed dose and continue the routine schedule. Avoid taking extra dose or 2 dose at one time. Please consult your doctor for further clarification.

 



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Zecyte

 
Brand Name : <--------------------> Zecyte
Category : <--------------------> Anti-Cancer Drugs
Sub Category :<--------------------> Abiraterone Acetate
Company Name :<--------------------> Cipla
Ingeridents(Generic Name) :<--------------------> Abiraterone acetate
Dosage Form :<--------------------> 120 tablets
Package :<--------------------> 1X120
Strength :<--------------------> 250mg

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