Imatib-40mg


QUICK OVERVIEW

Generic Name : Imatinib
Category : Anti-Cancer Drugs
Company Name : Cipla Ltd
Dosage Form: 100 tablets
Strength : 40mg

  

Availability: In Stock

Medicine Overview of Imatib-40mg Tablet


Uses of Imatib-40mg Tablet


Imatib 400mg is a cancer curable regimen which indicated for following conditions:

  • Aggressive systemic mastocytosis (ASM)
  •  Chronic eosinophilic leukemia (CEL)
  • Dermatofibrosarcoma protuberans (DFSP)
  •  Gastrointestinal stromal tumors (GIST)
  • Hypereosinophilic syndrome (HES)
  • Myelodysplastic syndrome (MDS)
  • Myeloproliferative diseases (MPD)
  • Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL)

Side effects of Imatib-40mg Tablet


The following side effects of Imatib 400mg occurring in >30% for patients

  • Low RBC,WBC and platelets: May increased risk for infection, anemia or bleeding; Nausea and vomiting; Swelling of the face, feet, hands (edema) ; Muscle cramps and bone pain; Diarrhea; bleeding problem; Skin rash; Fever.

Less common side effects of Imatib 400mg

  • Dyspnea; fatigue; athralagia; stomach cramping; heartburn; cold; decreased appetite; constipation, night sweat; weakness; problems in fertility.

How to use Imatib-40mg Tablet


Adult : PO 

Chronic myeloid leukaemia 

  • Chronic phase: 400 mg per day,  given up to 600 mg/day or 400 mg bid if needed.
  • Blast crisis or accelerated phase: 600 mg per day, up to 400 mg bid if required.

Dose of 600 mg per day with induction, consolidation or maintenance  therapy for Acute lymphoblastic leukaemia; Monotherapy in relapsed or refractory acute lymphoblastic leukaemia

Unresectable, metastatic GI stromal tumours 400 mg per day up to 400 mg bid. 

Hypereosinophilic syndrome 400 mg/day. Initial with 100 mg per day in patients w/ith FIP1L1-PDGF-α fusion kinase.

 Myelodysplastic disease:  400 mg per day. 

Mastocytosis 400 mg per day. Initial with100 mg/day if there is analog eosinophilia. 

Dermatofibrosarcoma protuberans: 400 mg bid.

Imatib 400mg should be taken with food by oral route.

How to Imatib-40mg Tablet works:


Imatib 400mg is a antineoplastic drug which inhibits the growth of cancer cells and bone marrow condition. Imatib 400mg is also knowns as tyrosine kinase inhibitor that interferes with the BCR-ABL tyrosine kinase produced by the Philadelphia chromosome abnormality in chronic myeloid (blood cancer) leukaemia(CML). It stops the multiplication and induces suppress  in BCR-ABL positive cell lines, thereby leukaemic cells from Philadelphia chromosome positive CML. Imatib 400mg also prevent receptor kinases for platelet-derived growth factor (PDGF) and stem cell factor (SCF), c-kit, PDGF- and SCF-mediated cellular effects.
Pharmacokinetics: 
Absorption: Fast and well absorbed from the GI tract. Bioavailability of Imatib 400mg  is Approx 98%. Duration of peak plasma concentration: 2-4 hr.
Distribution: Plasma protein binding of  Imatib 400mg Approx 95%.
Metabolism: Imatib 400mg  metabolized in  CYP3A4 isoenzyme and to a lesser extent through  CYP1A2, CYP2D6, CYP2C9 and CYP2C19 isoenzymes.active metabolite of Imatib 400mg is  N-demethylated piperazine derivative.
Excretion:  Eliminated through faeces (68%) and urine (13%) within 7 days; excreted mostly as metabolites, with 25% as unchanged drug. Elimination half-life: Approx 18 hr Imatib and approx 40 hr (N-demethylated piperazine derivative).


In Depth Information on Imatib-40mg Tablet:


Expert Advice for Imatib-40mg Tablets


While taking Imatib 400mg, Inform your doctor about previously taking medicine involved in prescription and non prescription, over the counter, vitamins, herbal, nutritional supplements.

  • Avoid taking aspirin, or products containing aspirin until doctor specifically permit may decrease the effectiveness of this medication.

  •   Acetominophen (Tylenol®) may not be recommended. Inform your doctor

  • Kindly discuss with  health care professional if you are pregnant or chance of to be pregnant before starting this treatment. 

  • For both men and women: Do not conceive a child (get pregnant) whileon treatment with Imatib 400mg. Barrier methods of contraception, such as condoms, are recommended. Discuss with your consultants , it will be safe to  become pregnant or conceive a child after treatment.

  • Avoid  breast feed while on medication therapy

Special Warnings of Imatib-40mg Tablets



Alcohol


Alcohol interaction with Imatib 400mg is unknown. Please consult with your doctor.

Pregnancy


Pregnancy category D: Imatib 400mg  has positive effects on human fetal risk, but the asist from use in pregnant women may be occur even with the risk . It is ineffective while the drug needed for life threatening situation.

Lactation


Imatib 400mg tablet excreted into human milk. Avoid breastfeed during treatment and for 1month after the last dose due to serious adverse reactions in breastfed infants.

Driving


Imatib 400mg may cause dizzy, drowsy and affect the ability to drive



Kidney


Patients with mild and moderate renal problem increased with normal renal function and not sufficient data in patients with severe renal impairment. Dosage adjustment is required with moderate and severe renal impairment.

Liver


Patients with severe liver disease should be used with caution. Dose adjustment is necessary using Imatib 400mg tablet. Please consult the doctor



Missed Dosage


If any doses missed by you, administer the dose as soon as possible you remember,If it is near to next dose then skip the missed dose and follow the regular schedule.. Do not take extra or 2 dose at a time. Do not administer the missed dose within 12hrs of the next dose.



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Imatib-40mg

 
Brand Name : <--------------------> Imatib-40mg
Category : <--------------------> Anti-Cancer Drugs
Sub Category :<--------------------> Imatinib
Company Name :<--------------------> Cipla Ltd
Ingeridents(Generic Name) :<--------------------> Imatinib
Dosage Form :<--------------------> 100 tablets
Package :<--------------------> 10X10
Strength :<--------------------> 40mg

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