Gefticip


QUICK OVERVIEW

Generic Name : Gefitinib
Category : Anti-Cancer Drugs
Company Name : Cipla Ltd
Dosage Form: 30 TABLETS
Strength : 250mg

  

Availability: In Stock

Medicine Overview of Gefticip Tablet


Uses of Gefticip Tablet


 Gefticip 250mg tablet is indicated for the treatment of metastatic non-small cell lung cancer with certain type of abnormal epidermal growth factor receptor (EGFR).

Side effects of Gefticip Tablet


 Common side effects  in Gefticip 250mg (occurring in greater than 30%):

   Loose stools; skin reaction

Less common in Gefticip 250mg (occurring in about 10-29%):

  • Nausea
  • Vomiting
  • Itching
  • Poor appetite
  • Eye irritation

How to use Gefticip Tablet


Patient selection

Patient is selected by the first-line treatment of metastatic non-small cell lung cancer with Gefticip based on presence of EGFR exon 19 deletion or exon 21 (l858R) substitution mutation in their tumor.

Prescribed dose of Gefticip 250mg

In adult 250mg once in a day and given with or without food until disease progression or unacceptable toxicity.

If patient have difficulty in swallowing tablet then immerse the tablet in 4 to 8 ounce of water for approx 15 mints and drink the liquid. Rinse with water of same level and immediately administer it.

OVERDOSAGE: Gefticip has no specific treatment for the overdose.an increase of dose frequency and severity of some adverse reaction was observed like diarrhea and skin rash.

How to Gefticip Tablet works:


EGFR is a kind of protein found on the surface of cells in your body. Mutated EGFR plays a part in cancer growth by sending out signals that make the cells grow and divide.

But Gefticip may make a difference for you.attaches itself to certain abnormal types of the EGFR protein on your lung cancer cells. By doing so, it has been shown to slow down the growth of these cells and may help reduce the size of your tumors.

ABSORPTION: slow absorbed from GI tract, the  bioavailability shows of approx 60% and peak plasma concentration time is 3-7hr.

DISTRIBUTION: volume of distribution in Gefticip is 1400L and plasma bounding is approx 90%.

METABOLISM: Gefticip metabolized by hepatic via CYP3A4 and CYP2D6. It has major metabolites is o-desmethylgeftinib.

ELIMINATION: Gefticip 250mg eliminated through  faeces (86%) and urine (<4%) and terminal half life is 41-48 hr.

 


In Depth Information on Gefticip Tablet:


Expert Advice for Gefticip Tablets


 

  •   Pirorly taking Gefticip treatment, confirmly inform your consultant about other prescription drugs, vitamin, herbal drugs, avoid aspirin and drug containg aspirin unless doctor specifically allow.

  • For pregnant women and partner men: while taking Gefticip, do not conceive or use contraception methods. Discuss with your doctor when you may safely become pregnant or conceive a child after treatment

  • Avoid use of Gefticip if you are pregnant. It will harm the baby unborn, while using Gefticip use correct birth control to prevent pregnancy and for at least 2 weeks after your treatment ends. Gefticip  may affect the ability to have children in women. Inform your doctor if you planning to pregnant.

  • It is  unknown whether Gefticip passes into breast milk , avoid breast-feed while on Gefticip treatment.


Special Warnings of Gefticip Tablets



Alcohol


Alcohol interaction with Gefticip 250mg is unknown. Please consult with the doctor.

Pregnancy


Category D: Gefticip 250mg show  human fetal risk, but the use in pregnant women may be occur even with the risk . It is ineffective  while the drug needed for life threatening situation.

Lactation


In animal studies show that  Gefticip 250mg and metabolite is present in milk of lactating rats. Hence while on treatment discontinue the breast feeding.

Driving


 Avoid driving unless you feeling well, while treatment with Gefticip 250mg you will feel dizzy, weekness and It affects the ability to drive.



Kidney


Gefticip 250mg tablet  should be used with caution in severe kidney problem patients. Ose adjustment is need. Please consult with the doctor.

Liver


Gefticip 250mg is safe to use in patients with liver disease, limited data available. Dose adjustment may not be needed. Please consult with the doctor.



Missed Dosage


If you missed a dose take it as soon as possible, if time reach for next dose, then skip missed dose and continue regular schedule. Do not take extra or 2 dose at a time. Please consult with doctor.



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Gefticip

 
Brand Name : <--------------------> Gefticip
Category : <--------------------> Anti-Cancer Drugs
Sub Category :<--------------------> Gefitinib
Company Name :<--------------------> Cipla Ltd
Ingeridents(Generic Name) :<--------------------> Geftinib
Dosage Form :<--------------------> 30 TABLETS
Package :<--------------------> 1X30
Strength :<--------------------> 250mg

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