Glenza


QUICK OVERVIEW

Generic Name : Enzalutamide
Category : Anti-Cancer Drugs
Company Name : Glenmark pharmaceuticals Ltd
Dosage Form: 112 tablets
Strength : 40mg

  

Availability: In Stock

Medicine Overview of Glenza Tablet


Uses of Glenza Tablet


Glenza 40mg is clinically effective and indicated in the treatment of anti tumor activity of MDV3100 in a phase I/II study of castration resistant prostate cancer.

Side effects of Glenza Tablet


While taking Glenza 40mg  consult with doctor immediately if any of the side effects occurs.

More common

Lumbar pain, Bloating of face, arms, hands, lower legs or feet.

Blurred vision, chest pain, breathing difficulty, loss of bladder control, nervousness.

Less common

Anxiety, excitement, fainting, loss of memory, rapid and shallow breathing

Rare side effect

Seizures

How to use Glenza Tablet


In adult usual dose is 160mg orally

Glenza available dose 40mg hence four capsule of 40mg dose given once daily.

Administrated once in a day has four tablet of 40mg capsule with or without food at same time every day.

Taken as a capsule by mouth, Swallow the capsule whole

Do not crush or chew or dissolve capsule.

OVERDOSE OF GLENZA: If overdose occur, will cause seizure. Seek emergency medical attention or call poison helpline.

How to Glenza Tablet works:


Glenza 40mg is an anti-androgen drug and it prevents androgen  receptor inhibitor that acts on different stages in the androgen receptor communicating pathway.

Glenza 40mg has been shown to repetitively interfere with androgen linking to androgen receptors and prevents androgen receptor nuclear translocation and interaction with DNA.

Glenza 40mg has a major metabolite, N‑desmethyl enzalutamide, show invitro activity to glenza.

Glenza 40mg reduce proliferation and induced cell death of prostate cancer cells inside the body, and lowers tumor volume in a mouse prostate cancer xenografts model.

ABSORPTION: Bioavailabilty of Glenza in human is unknown and in rate is 89.7%. peak plasma concentration is 1 hour (range 0.5 to 3 hours).

DISTRIBUTION: Plasma protein binding is 97 to 98% and metabolite N-desmethylenzalutamide

METABOLISM: The drug is metabolite in the liver by CYP2C8 and CYP3A4.

ELIMINATION: Excreted via urine 71.0%, bile in 13.6% and feces in 0.39%

 Half life is 5.8 days, with range of 2.8 to 10.2 days.


In Depth Information on Glenza Tablet:


Expert Advice for Glenza Tablets


  • Inform your doctor Before consuming the Glenza drug,about previous medicine that you have been taking (including prescription, over-the counter, vitamins, herbal remedies etc.
  • Routine blood test is monitor for the patient on warfarin treatment.
  • Previous history of seizures, brain injury, stoke or brain tumours should inform the doctor.
  • Without doctors approval or guidance, do not receive any kind of immunization and vaccination.
  • In women and partner men: avoid conceive a child (get pregnant) while taking Glenza.
  • Due to severe adverse reactions in the new born baby, breast-feeding is not recommended.

Special Warnings of Glenza Tablets



Alcohol


Alcohol interaction with Glenza 40mg is unknown. Please consult with doctor.

Pregnancy


In animal reproduction studies, there is a adverse effect for fetal, hence no human data on the use of Glenza in pregnancy. Glenza 40mg  is contraindicated in women during pregnancy and cause fetal death and potential loss of pregnancy.

Lactation


Glenza 40mg is not recommended to use in females. There is no information available in presence of Glenza in human milk. The effects in the nursing infants are unknown.

Driving


While taking this drug dizziness occurs, It will affect the ability of driving. Avoid driving unless you feeling well.



Kidney


When patients with mild ,moderate kidney disease no adjustment recommended. Patients with severe kidney problem or ESRD use with caution is recommended.

Liver


Glenza 40mg has no dosage adjustment is necessary in mild or severe renal impairment. Caution recommended in moderate liver disease in patients.



Missed Dosage


If you missed a dose take it as soon as possible, if time reach for next dose, then skip missed dose and continue regular schedule. Do not take extra or 2 dose at a time. Please consult with the doctor.

 



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Glenza

 
Brand Name : <--------------------> Glenza
Category : <--------------------> Anti-Cancer Drugs
Sub Category :<--------------------> Enzalutamide
Company Name :<--------------------> Glenmark pharmaceuticals Ltd
Ingeridents(Generic Name) :<--------------------> Enzalutamide
Dosage Form :<--------------------> 112 tablets
Package :<--------------------> 4X28
Strength :<--------------------> 40mg

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