Xtandi


QUICK OVERVIEW

Generic Name : Enzalutamide
Category : Anti-Cancer Drugs
Company Name : AStellas Pharma India Ltd
Dosage Form: 112 capsule
Strength : 40mg

  

Availability: In Stock

Medicine Overview of Xtandi Tablet


Uses of Xtandi Tablet


 Xtandi 40mg is indicated for the treatment of prostate cancer which has distribute through out the body in men who have been not got correct treatment with other Medicals and surgical treatment involves Taxotere,docefrez (docetaxel).

Side effects of Xtandi Tablet


While taking Xtandi 40mg, consult with doctor immediately if any of the side effects occurs.

More common

Lumbar pain, Bloating of face, arms, hands, lower legs or feet.

Blurred vision, chest pain, breathing difficulty, loss of bladder control, nervousness.

Less common

Anxiety, excitement, fainting, loss of memory, rapid and shallow breathing

Rare side effect

Seizures

How to use Xtandi Tablet


In adult usual dose is 160mg orally

Administrated once in a day has four tablet of 40mg capsule with or without food at same time every day.

Taken as a capsule by mouth, swallow the capsule whole

Do not crush or chew or dissolve capsule

OVERDOSE OF XTANDI: If overdose occur, will cause seizure. Seek emergency medical attention or call poison helpline.

How to Xtandi Tablet works:


Xtandi  40mg is an inhibitor of androgen receptor which acts on various steps in the androgen receptor waving pathway.

Xtandi 40mg has been shown to repetitively prevents androgen bound to androgen receptors and  interefere with  androgen receptor nuclear translocation and interact with DNA.

Xtandi 40mg has  a major metabolite, N‑desmethyl enzalutamide,presented same as activity to enzalutamide.

Enzalutamide reduce multipilication and induced cell death of prostate cancer cells inside the cell  and lowers the tumor volume in a mouse prostate cancer xenograft model.

ABSORPTION: Bioavailabilty of Xtandi 40mg in human is unknown and in rate is 89.7%. peak plasma concentration is 1 hour (range 0.5 to 3 hours).

DISTRIBUTION: Plasma protein binding is 97 to 98% and metabolite N-desmethylenzalutamide

METABOLISM: The drug is metabolite in the liver by CYP2C8 and CYP3A4.

ELIMINATION: Excreted via urine 71.0%, bile in 13.6% and feces in 0.39% Half life is 5.8 days, with range of 2.8 to 10.2 days.


In Depth Information on Xtandi Tablet:


Expert Advice for Xtandi Tablets


  • Before consuming the  Xtandi 40mg , Inform your doctor about previous medicine that you have been taking (including prescription,over-the counter, vitamins, herbal remedies etc.

  • Routine blood test is monitor for the patient on warfarin treatment.

  • Previous history of seizures, brain injury,stoke or brain tumours should inform the doctor.

  • Without doctors approval or guidance, do not receive any kind of immunization and vaccination.

  • In women and partner men: avoid conceive a child (get pregnant) while taking  Xtandi. Barrier methods of contraception, such as condoms, are recommended. Discuss with your doctor when you may safely become pregnant or conceive a child after therapy.

  • in the new born baby, breast-feeding is not recommended.


Special Warnings of Xtandi Tablets



Alcohol


Alcohol interaction with Xtandi 40mg is unknown. Please consult with doctor.

Pregnancy


In animal reproduction studies, there is a adverse effect for fetal, hence no human data on the use of Xtandi in pregnancy. Xtandi is contraindicated in women during pregnancy and cause fetal death and potential loss of pregnancy.

Lactation


Xtandi 40mg  is not recommended to use in females. There is no information available in presence of Xtandi in human milk. The effects in the nursing infants are unknown.

Driving


While taking this drug dizziness occurs, It will affect the ability of driving. Avoid driving unless you feeling well.



Kidney


When patients with mild ,moderate kidney disease no adjustment recommended. Patients with severe kidney problem or ESRD use with caution is recommended.

Liver


Xtandi 40mg has no dosage adjustment is necessary in mild or severe renal impairment. Caution recommended in moderate liver disease in patients.



Missed Dosage


If you missed a dose take it as soon as possible, if time reach for next dose, then skip missed dose and continue regular schedule. Do not take extra or 2 dose at a time.Please consult with doctor



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Xtandi

 
Brand Name : <--------------------> Xtandi
Category : <--------------------> Anti-Cancer Drugs
Sub Category :<--------------------> Enzalutamide
Company Name :<--------------------> AStellas Pharma India Ltd
Ingeridents(Generic Name) :<--------------------> Enzalutamide
Dosage Form :<--------------------> 112 capsule
Package :<--------------------> 4X28
Strength :<--------------------> 40mg

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