Canmab


QUICK OVERVIEW

Generic Name : Trastuzumab
Category : Anti-Cancer Drugs
Company Name : Roche product india Pvt Ltd
Dosage Form: 1 vial
Strength : 440mg

  

Availability: In Stock

Medicine Overview of Canmab Tablet


Uses of Canmab Tablet


Treatment with Canmab injection is indicated for the following diseases:

  • Breast cancer which spread to other part of body

  • Combination with other medication to reduce chance of breast cancer relapsed

  • Adjuvant treatment of lymph-node positive

  • Gastric cancer

For other cancer including ovarian, colon, endometrial, lung, bladder, prostate 

Side effects of Canmab Tablet


Serious side effects which causes from Canmab injection treatment

Sore throat, fever, chills, fever, difficulty urinating, pain during urinating and other signs of infection.

How to use Canmab Tablet


Breast cancer Metastatic HER2-Overexpressing:

  • Over a 90 minutes, 4mg/kg alone or with combination of paclitaxel in intial dose.

  • Over 30 minutes , 2mg /kg once in a week for maintenance dose.

  • Duration of therapy for intial and maintenance dose until disease progression.

Adjuvent regimen for HER2 overexpressing Breast cancer:

52 weeks of treatment total schedules as follows:

  • Combination With paclitaxel or docetaxel ,over a 90 minutes, 4mg/kg IV then over 30 minutes , 2mg /kg for 12 weeks or combination with Carboplatin/ docetaxel for 18 weeks one week following the last weekly dose.

  • Over 30 to 90 minutes, 6mg/kg IV for every 3 weeks.

Esophageal carcinoma or gastric cancer for adult dose:

  • 8mg/kg IV over 90 minutes as initial dose

  • 6mg/kg IV over 30 to 90 minutes for every 3 weeks as maintenance dose

  • Duration of therapy for intial and maintenance dose until disease progression.

 

Administration:

Canmab is administer into vein through IV infusion over 90 minutes

Do not administer IV push or bolus.

Usually given once every week or every 3 weeks.

Before starting treatment, patients should undergo biopsy to check Canmab is the right regimen..

OVERDOSE: there is no appearance of overdose. don not miss the cycle  and follow up the doctors instruction.

How to Canmab Tablet works:


Canmab mechanism by aiming the HER2/neu receptor on cancer cells.  The HER2 gene gives a protein receptor on the cell surface which divide the cell by normal cell growth signals and multiply. 

Some breast cancer tissue has too much HER2  overexpression, triggering the cells to divide and multiply very rapidly. 

Canmab binds to the HER2 receptors to inhibits the cells from multiplying by preventing further cancer growth and slowing cancer progression. 

Canmab also acts by stimulating an immune mechanism..

Distribution: Volume of distribution: 44 mL/kg as trastuzumab; 3.13 L as trastuzumab emtansine.
Metabolism: As trastuzumab emtansine: which Undergoes deconjugation and catabolism through proteolysis in cellular lysosomes.
Excretion: Terminal Elimination half-life is 6 days (weekly dosing); 16 days (3 weekly regimen); approx 4 days as trastuzumab emtansine.

Elimination may involve clearance of IgG through the reticuloendothelial system.


In Depth Information on Canmab Tablet:


Expert Advice for Canmab Tablets


  • Discuss with  doctor that any other medications you are taking i.e prescription, over-the-counter, vitamins, herbal remedies, etc. Piror to Canmab treatment. 

  • Inform your doctor about pregnancy or may be pregnant before initating the treatment.  Pregnancy category B there is no evidence of risk in humans based on negative animal studies.  Usage of drug during pregnancy only if clearly needed.

  • For both men and women drug is not recommended to conceive a child  or get pregnant while administrating Canmab  injection. Precaution methods of contraception, such as condoms, can be used. You can ask with doctor about the safely become pregnant or conceive a child after treatment.

  • Avoid giving breast feed to infants while taking Canmab injection.


Special Warnings of Canmab Tablets



Alcohol


Alcohol interaction with Canmab 440mg injection is unknown. Please consult with your doctor.

Pregnancy


Canmab 440mg injection is probably unsafe to use during pregnancy, since there is a positive evidence of human fetal risk, the usage in pregnant women may be produce against the risk.

Lactation


Canmab 440mg is unknown whether excreted into human milk, An decision should preferred whether to discontinue the breastfeeding or the drug, considering the importants of the drug to the breastfed mother.

Driving


Canmab 440mg injection is unknown whether it will affect the ability to drive. If any symptoms occurs while drive then avoid driving unless you feeling well.



Kidney


Patients with kidney problem is probably safe to use. Limited information available on dose adjustment. Please consult the doctor.

Liver


Patients with liver disease using Canmab 440mg injection has available limited information. Please consult with your doctor.



Missed Dosage


If any doses missed by you, administer the dose as soon as possible you remember,If it is near to next dose then skip the missed dose and follow the regular schedule.. Do not take extra or 2 dose at a time. Do not administer the missed dose within 12hrs of the next dose.



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Canmab

 
Brand Name : <--------------------> Canmab
Category : <--------------------> Anti-Cancer Drugs
Sub Category :<--------------------> Trastuzumab
Company Name :<--------------------> Roche product india Pvt Ltd
Ingeridents(Generic Name) :<--------------------> Trastuzumab
Dosage Form :<--------------------> 1 vial
Package :<--------------------> 1x1
Strength :<--------------------> 440mg

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