Resof-Hepcfix


QUICK OVERVIEW

Sub Category : Sofosbuvir-Daclatasvir
Category : Hepatitis Drugs
Company Name : Dr.Reddy's
Dosage Form : 28 Tablets
Strength : 400mg & 60mg

  

Availability: In Stock

Medicine Overview of Resof-Hepcfix Tablet


Uses of Resof-Hepcfix Tablet


Resof  and Hepcfix is a very effective antiviral drug which is used for treatment  of chronic hepatitis C virus (HCV) genotype 1 or 3 infection, with or without ribavirin.

Side effects of Resof-Hepcfix Tablet


 When Resof and Hepcflix adminstrating of combination with amiodarone will cause some side effects on heart and seek medical help if you have:

Normal effects: Muscle ache; Energy lost; Rash and itchiness; chronic insomnia; headache; weight loss; mental illness; fever; Diarrhae.

Major side effects: Skin yellowish; difficult to breath;sore throat; changes in behavior; Anemia

How to use Resof-Hepcfix Tablet


In adult recommended dosage of  Resof is 400 mg and Hepcfix  is 60 mg. Both drugs administrated through orally, once in a day. Given with or without food.

For genotype 1:Resof  plus Hepcfix is administrated with compensated cirrhosis or without cirrhosis     ( child-pugh A)for 12weeks.  Both drugs with ribavirin combination  is used  for decompensated cirrhosis  (child – pugh B or C) and Posttransplant

For genotype 3 : Daclatasvir  plus Sofosbuvir without cirrhosis for 12weeks.  Resof  plus Hepcfix and ribavirin combination used for compensated or decompensated ( child-pugh B or C) cirrhosis and Posttransplant for 12weeks.

      Overdose of Resof and Hepcfix: No specific antidote available, If overdose occur, patient should be monitor the development of toxicity and supportive and symptomatic care should be monitor. Seek medical emergency or call poison control for immediate treatment

How to Resof-Hepcfix Tablet works:


Resof is a nucleotide polymerase inhibitor and includes in direct acting antiviral drug. Resof by interfere with the RNA polymerase enzyme by the cellular worker which will performs the replication process, thereby  it stops the multiplication of Hepatitis C  virus and decrease the amount of Hep C virus in liver. Resof also acts  to lower liver damage and improves function of liver.

Hepcfix is a direct acting antiviral drug which is indicated for the patient affected by hepatitis c virus infection. It will targets the Hep C virus and stops the numerous steps in reproduction process of HCV by the way it interfere with the virus particles from making copies themselves, and  helps the body to remove virus  from the blood.

Absorption:- Resof peak plasma concentration of obtained at -0.5 to 2 hr post dose and in metabolite GS-331007 peak plasma concentration  obtained between 2 to 4 hrs post dose, where as In Hepcfix  peak plasma concentration is within 2 hours post dose and bioavailability is 67%

Effect of food: Resof and the metabolite have no affect with high fat meal. Hence Myhep is administrated without food is effective. In Hepcfix  drug either taken with food  nor without food.

Distribution: Resof  is approx 51-65% bound to human plasma proteins and GS-331007 metabolite has minimal human plasma protein binding. And in Hepcflix, the plasma protein binding is 99%

Metabolism:  Resof is broadly metabolized in liver (4% and >90%) to convert into pharmacologically active nucleoside analog triphosphate GS-461203. Hepcflix metabolism based on the substrate of CYP3A with primry CYP isoform

Elimination:  Resof elimination in urine 80%, feces 14% and 2.5%expired air. While single dose administration , Hepcfix elimination of radioactivity was recovered 88% via feces and 6.6% via urine

Half life of  Resof  and GS-331007 were 0.4 and 27hrs and Hepcflix

has  half life elimination of 12 to 15 hours .


In Depth Information on Resof-Hepcfix Tablet:


Expert Advice for Resof-Hepcfix Tablets


  • Combination of Resof plus Hepcflix and amiodarone may cause bradycardia

  • Drugs should given with prescription only, without prescription drugs should not be issued.
  • Inform your healthcare providers that you are allergic to daclatasvir ,Sofosbuvir or  have any other allergies before using the medicine. It may composed of inactive ingredients, that can  be cause allergic problems or other reaction. Talk to your pharmacist for more details.
  •  Especially if you had any  kidney disease, liver disease other than hepatitis C, inform your consultant about past medical history before having daclatasvir / Sofosbuvir.

Special Warnings of Resof-Hepcfix Tablets



Alcohol


Alcohol interaction with Resof  plus Hepcfix combination is unknown. Please consult with doctor.

Pregnancy


Pregnancy category B for Resof  plus Hepcfix combination, In all trimester there are no adequate and well tolerated studies in pregnant women, Since animal reproduction trial has no risks and adverse effect to the fetus. But  with ribavirin combination,pregnancy category X cause to birth defect  and death to the fetus. Avoid combination therapy during pregnancy.

Lactation


Resof  plus Hepcfix excreted into human milk is unknown, therefore its recommended that mother should not breast feed during Resof  plus Hepcfix combination treatment.

Driving


While using Resof  plus Hepcfix combination you may get dizziness, weakness and confusion and make tried. So avoid driving until you feeling well. Please consult with doctor



Kidney


No dosage adjustment recommended with mild , moderate kidney problem and limited information about this drug. So please consult with doctor and inform him before taking Resof  plus Hepcfix tablet.

Liver


Resof  plus Hepcfix administration, patients with mild , moderate and severe dysfunction has no dosage adjustment. Please consult with your doctor.



Missed Dosage


If you missed a dose take it as soon as possible, if time reach for next dose, then skip missed dose and continue regular schedule. Do not take extra or 2 dose at a time. TAKE ADVICE FROM THE DOCTOR



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Resof-Hepcfix

 
Brand Name : <--------------------> Resof-Hepcfix
Category : <--------------------> Hepatitis Drugs
Sub Category :<--------------------> Sofosbuvir-Daclatasvir
Company Name :<--------------------> Dr.Reddy's
Ingeridents(Generic Name) :<--------------------> Sofosbuvir & Daclatasvir
Tablets :<--------------------> 28 Tablets
Package :<--------------------> 3x28
Strength :<--------------------> 400mg & 60mg

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