Sofovir-Daclahep


QUICK OVERVIEW

Sub Category : Sofosbuvir-Daclatasvir
Category : Hepatitis Drugs
Company Name : Hetero
Dosage Form : 28 Tablets
Strength : 400mg & 60mg

  

Availability: In Stock

Medicine Overview of Sofovir-Daclahep Tablet


Uses of Sofovir-Daclahep Tablet


Sofovir plus daclahep is an direct acting antiviral drug which contain active ingredients of Sofosbuvir 400mg and daclatasvir 60mg and with or without ribavirin is indicated for the treatment of chronic hepatitis C virus genotype 1 or 3 infection.

Side effects of Sofovir-Daclahep Tablet


When administrating Sofovir and Daclahep with combination with amiodarone will cause some side effects on heart and seek medical help if you have:

Decreased heartbeat

Difficulty in breathing, Chest discomfort

Lightheadness

Serious side effects:

Loss of Memory and confusion

Severe vertigo

Severe weakness

Common effects:

Head pain

Triedness.

How to use Sofovir-Daclahep Tablet


Sofovir plus daclahep is an antiviral drug for treatment of chronic Hep C virus and the dose recommended is Sofosbuvir 400mg and daclatasvir  60mg which is administrated via oral route once in a day and given with or without food.

Sofovir plus daclahep  administrated for patients with compensated cirrhosis or without cirrhosis for 12 weeks and combined with ribavirin used with decompensated cirrhosis and posttransplant for genotype 1

Sofovir plus daclahep  without cirrhosis for 12weeks. Sofovir , Daclahep  and ribavirin combination used for compensated or decompensated ( child-pugh B or C) cirrhosis and Posttransplant for 12weeks for genotype 3.

Overdose of Sofovir and Daclahep: No specific antidote available, If overdose occur, patient should be monitor the development of toxicity and supportive and symptomatic care should be monitor. Seek medical emergency or call poison control for immediate treatment

How to Sofovir-Daclahep Tablet works:


Sofovir is an antiviral drug and called as nucleotide polymerase inhibitor. Sofovir reveal to have a high barrier to the development of resistance and inhibits the hep C NS5B protein. And also inhibits the  RNA polymerase enzyme by the cellular worker which will performs the multiplication process, Hence it stops the replication of Hepatitis C virus and decrease the amount of Hep C virus in liver. Sofovir also acts to reduce damage in liver and improves function in liver.

Daclahep is a direct acting antiviral drug which is used for the patient affected by hepatitis c virus infection. It will targets the Hepatitis C virus and blocks the numerous steps in reproduction process of HCV by the way it interfere with the virus particles from making copies themselves, and  helps the body to remove virus  from the blood.

  Absorption:- Sofovir peak plasma concentration of obtained at -0.5 to 2 hr post dose and where as In Daclahep, peak plasma concentration is within 2 hours post dose and bioavailability is 67%

Effect of food:.  Sofovir is administrated without food is effective. In Daclahep  drug either  taken with food  nor without food.

Distribution: Sofovir is approx 51-65% bound to human plasma proteins and in Daclahep , the plasma protein binding is 99%

Metabolism:  :  Sofovir is broadly metabolized in liver (4% and >90%) to convert into pharmacologically active nucleoside analog triphosphate GS-461203. Daclahep metabolism based on the substrate of CYP3A with primry CYP isoform

Elimination:  Sofovir elimination in urine 80%, feces 14% and 2.5%expired air. While single dose administration , Daclahep elimination of radioactivity was recovered 88% via feces and 6.6% via urine

Half life of Sofovir and GS-331007 were 0.4 and 27hrs and Daclahep has  half life elimination of 12 to 15 hours


In Depth Information on Sofovir-Daclahep Tablet:


Expert Advice for Sofovir-Daclahep Tablets


  • Combination of Sofovir plus daclahep and amiodarone may cause bradycardia

  • Drugs should given with prescription only, without prescription drugs should not be issued.

  • Inform your healthcare providers that you are allergic to daclatasvir ,Sofosbuvir or  have any other allergies before using the medicine. It may composed of inactive ingredients, that can  be cause allergic problems or other reaction. Talk to your pharmacist for more details.

  • If you had any  kidney disease, liver disease other than hepatitis C, inform your consultant about past medical history before having daclatasvir / Sofosbuvir.


Special Warnings of Sofovir-Daclahep Tablets



Alcohol


Alcohol interaction with Sofovir plus daclahep combination is unknown. Please consult with doctor.

Pregnancy


Pregnancy category B for Sofovir plus daclahep combination, In all trimester there are no adequate and well tolerated studies in pregnant women, Since animal reproduction trial has no risks and adverse effect to the fetus. But  with ribavirin combination, pregnancy category X cause to birth defect  and death to the fetus. Avoid combination therapy during pregnancy.

Lactation


Sofovir plus daclahep  excreted into human milk is unknown, therefore its recommended that mother should not breast feed during Sofovir plus daclahep  combination treatment.

Driving


While using Sofovir plus daclahep  combination you may get dizziness, weakness and confusion and make tried. So avoid driving until you feeling well. Please consult with doctor



Kidney


No dosage adjustment recommended with mild , moderate kidney problem and limited information about this drug. So please consult with doctor and inform him before taking Sofovir plus daclahep  tablet.

Liver


Sofovir plus daclahep  administration, patients with mild , moderate and severe dysfunction has no dosage adjustment. Please consult with your doctor.



Missed Dosage


If you missed a dose take it as soon as possible, if time reach for next dose, then skip missed dose and continue regular schedule. Do not take extra or 2 dose at a time. TAKE ADVICE FROM THE DOCTOR



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Sofovir-Daclahep

 
Brand Name : <--------------------> Sofovir-Daclahep
Category : <--------------------> Hepatitis Drugs
Sub Category :<--------------------> Sofosbuvir-Daclatasvir
Company Name :<--------------------> Hetero
Ingeridents(Generic Name) :<--------------------> Sofosbuvir 400mg & Daclatasvir 60mg
Tablets :<--------------------> 28 Tablets
Package :<--------------------> 3x28
Strength :<--------------------> 400mg & 60mg

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