Medicine Overview of MyHep-MyDekla Tablet
Uses of MyHep-MyDekla Tablet
Myhep plus Mydekla is used for the treatment of chronic hepatitis C virus (HCV) genotype 1 or 3 infection with or without ribavirin.
Side effects of MyHep-MyDekla Tablet
When Myhep and Mydekla adminstrating of combination with amiodarone will cause some side effects on heart and seek medical help if you have:
Shortness of breath , Chest discomfort
Serious side effects:
Infection like sore throat
Loss of Memory and confusion
How to use MyHep-MyDekla Tablet
In adult recommended dosage of Myhep is 400 mg and Mydekla is 60 mg.Both drugs administrated through orally, once in a day.
Given with or without food.
For genotype 1
Myhep plus Mydekla without cirrhosis or with compensated cirrhosis ( child-pugh A)for 12weeks. Myhep , Mydekla and ribavirin combination is used for decompensated cirrhosis (child – pugh B or C) and Posttransplant
For genotype 3
Daclatasvir plus Sofosbuvir without cirrhosis for 12weeks. Myhep , Mydekla and ribavirin combination used for compensated or decompensated ( child-pugh B or C) cirrhosis and Posttransplant for 12weeks.
Overdose of Myhep and Mydekla: No specific antidote available, If overdose occur, patient should be monitor the development of toxicity and supportive and symptomatic care should be monitor. Seek medical emergency or call poison control for immediate treatment
How to MyHep-MyDekla Tablet works:
Mydekla is a direct acting antiviral drug which is indicated for the patient affected by hepatitis c virus infection. It will targets the Hep C virus and stops the numerous steps in reproduction process of HCV by the way it interfere with the virus particles from making copies themselves, and helps the body to remove virus from the blood.
Myhep is a nucleotide polymerase inhibitor and includes in direct acting antiviral drug. Myhep expose to have a high barrier to the development of resistance and inhibits the hep C NS5B protein and It will inhibits the RNA polymerase enzyme by the cellular worker who can performs the multiplication process, Hence it stops the replication of Hepatitis C virus and decrease the amount of Hep C virus in liver. Myhep also acts to reduce damage in liver and improves function in liver
Absorption:- Myhep peak plasma concentration of obtained at -0.5 to 2 hr post dose and in metabolite GS-331007 peak plasma concentration obtained between 2 to 4 hrs post dose, where as In Mydekla peak plasma concentration is within 2 hours post dose and bioavailability is 67%
Effect of food: Myhep and the metabolite have no affect with high fat meal. Hence Myhep is administrated without food is effective. In Mydekla drug either taken with food nor without food.
Distribution: Myhep is approx 51-65% bound to human plasma proteins and GS-331007 metabolite has minimal human plasma protein binding. And in Mydekla , the plasma protein binding is 99%
Metabolism: Myhep is broadly metabolized in liver (4% and >90%) to convert into pharmacologically active nucleoside analog triphosphate GS-461203. Mydekla metabolism based on the substrate of CYP3A with primry CYP isoform
Elimination: Myhep elimination in urine 80%, feces 14% and 2.5%expired air. While single dose administration of Mydekla, elimination of radioactivity was recovered 88% via feces and 6.6% via urine
Half life of Myhep and GS-331007 were 0.4 and 27hrs and Mydekla has half life elimination of 12 to 15 hours
In Depth Information on MyHep-MyDekla Tablet:
Expert Advice for MyHep-MyDekla Tablets
- Combination of Myhep, Mydekla and amiodarone may cause bradycardia
- Drugs should given with prescription only, without prescription drugs should not be issued.
- Inform your healthcare providers that you are allergic to daclatasvir ,Sofosbuvir or have any other allergies before using the medicine. It may composed of inactive ingredients, that can be cause allergic problems or other reaction. Talk to your pharmacist for more details.
- Especially if you had any kidney disease, liver disease other than hepatitis C, inform your consultant about past medical history before having daclatasvir / sofosbuvir
Special Warnings of MyHep-MyDekla Tablets
Alcohol interaction with Myhep plus Mydekla combination is unknown. Please consult with doctor.
Pregnancy category B for Myhep plus Mydekla combination, In all trimester there are no adequate and well tolerated studies in pregnant women, Since animal reproduction trial has no risks and adverse effect to the fetus. But with ribavirin combination,pregnancy category X cause to birth defect and death to the fetus. Avoid combination therapy during pregnancy.
Myhep plus Mydekla excreted into human milk is unknown, therefore its recommended that mother should not breast feed during Myhep plus Mydekla combination treatment.
While using Myhep plus Mydekla combination you may get dizziness, weakness and confusion and make tried. So avoid driving until you feeling well. Please consult with doctor.
No dosage adjustment recommended with mild , moderate kidney problem and limited information about this drug. So please consult with doctor and inform him before taking Myhep plus Mydekla tablet.
Myhep plus Mydekla administration, patients with mild , moderate and severe dysfunstion has no dosage adjustment. Please consult with your doctor.
If you missed a dose take it as soon as possible, if time reach for next dose, then skip missed dose and continue regular schedule. Do not take extra or 2 dose at a time. TAKE ADVICE FROM THE DOCTOR.
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Brand Name : <--------------------> MyHep-MyDekla
Category : <--------------------> Hepatitis Drugs
Sub Category :<--------------------> Sofosbuvir-Daclatasvir
Company Name :<--------------------> Mylan
Ingeridents(Generic Name) :<--------------------> Sofosbuvir 400mg & Daclatasvir 60mg
Tablets :<--------------------> 28 Tablets
Package :<--------------------> 3x28
Strength :<--------------------> 400mg &60mg